A Preliminary Note on Spatial EEG Correlates of Olfactory Conditioning

  • Kamil A. Grajski


The vertebrate olfactory epithelium (100–200 µm thick) covers roughly 100 cm2 and contains 106–108 receptor cells. Each receptor cell has a broad response characteristic to odorants (Lancet, 1986). Odorant information is conveyed topographically to the main olfactory bulb (OB) via the primary olfactory nerve (PON) as spatial patterns of spike trains generated by the noninteracting receptor cells. The PON fibers converge onto 103 glomeruli in the OB glomerular layer. Within each glomerulus (80–150 µm in diameter), 103–105 PON fibers synapse with the apical dendrites of 102–103 mitral and tufted cells. The mitral and tufted cells form reciprocal synapses with 103–104 deep-lying granule cells. Mitral—granule cell interactions are mediated by a sigmoidal gain function (Eeckman and Freeman, 1986). Under synaptic driving, the nonspiking granule cells generate electric dipoles with common instantaneous orientation perpendicular to the bulbar surface. These field potentials form the predominant component of the EEG activity recorded at the bulbar surface (Freeman, 1975). Mitral cell axons converge to form the lateral, olfactory tract (LOT), which projects topographically to the anterior olfactory nucleus but nontopographically to the prepiriform cortex. These structures project back to the bulb in a similar fashion.


Olfactory Bulb Main Olfactory Bulb Tufted Cell Amyl Acetate Olfactory Discrimination 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Kamil A. Grajski
    • 1
  1. 1.Graduate Group in BiophysicsUniversity of California at BerkeleyBerkeleyUSA

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