Catecholaminergic and Opioid Mechanisms in Conditioned Food Intake Behavior of the Monkey Amygdala

  • Yutaka Oomura
  • Yasuhiko Nakano
  • László Lénárd
  • Hitoo Nishino
  • Shuji Aou

Abstract

Amygdalar neurons respond to complex visual stimuli and activity changes at the sight of food (Ono et al., 1983; Sanghera et al., 1979). The amygdala (AM) is among the richest of the brain areas in opioid receptors and endogenous ligands, but the functional role of its opioid system in feeding behavior is not yet understood.

Keywords

Firing Rate Intertrial Interval Central Nucleus Passive Avoidance Conditioning Amygdalar Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aou, S., Oomura, Y., Nishino, H., Inokuchi, A., and Mizuno, Y., 1983, Influence of catecholamines on reward-related neuronal activity in monkey orbitofrontal cortex, Brain Res. 267: 165–170.PubMedCrossRefGoogle Scholar
  2. Aou, S., Oomura, Y., Lénârd, L., Nishino, H., Inokuchi, A., Minami, T. and Misaki, H., 1984, Behavioral significance of monkey hypothalamic glucose-sensitive neurons, Brain Res. 302: 69–74.PubMedCrossRefGoogle Scholar
  3. Beninger, R. J., 1983, The role of dopamine in locomotor activity and learning, Brain Res. Rev. 6: 173–196.CrossRefGoogle Scholar
  4. Ellis, M. E., 1984, Manipulation of the amygdala noradrenergic system impairs extinction of passive avoidance, Brain Res. 324: 129–133.PubMedCrossRefGoogle Scholar
  5. Gallagher, M., Kapp, B. S., Pascoe, J. P., and Rapp, P. R., 1981, A neuropharmacology of amygdala systems which contribute to learning and memory, in: The Amygdaloid Complex (Y. Ben-Ari, ed.), Elsevier, Amsterdam, pp. 343–354.Google Scholar
  6. Goodman, R. R., Snyder, S. H., Kuhar, M. J., and Young, W. S., III, 1980, Differentiation of delta and mu opiate receptor localization by light microscopic autoradiography, Proc. Natl. Acad. Sci. U.S.A. 77: 62396243.Google Scholar
  7. Halsband, V., and Passingham, R., 1982, The role of premotor and parietal cortex in the direction of action, Brain Res. 240: 368–372.PubMedCrossRefGoogle Scholar
  8. Heffner, T. G., Luttinger, D., Hartman, J. A., and Seiden, L. S., 1981, Regional changes in brain catecholamine turnover in the rat during performance of fixed ratio and variable interval schedules of reinforcement, Brain Res. 214: 215–218.PubMedCrossRefGoogle Scholar
  9. Kusama, T., and Mabuchi, M., 1970, Stereotoxic Atlas of the Brain of Macaca fuscata, University of Tokyo Press, Tokyo.Google Scholar
  10. Leibowitz, S. F., 1980, Neurochemical systems of the hypothalamus: Control of feeding and drinking behavior and water—electrolyte excretion, in: Handbook of the Hypothalamus, Volume 3, Part A ( P. J. Morgane and J. Panksepp, eds.), Marcel Dekker, New York, pp. 299–437.Google Scholar
  11. Lénârd, L., and Hahn, Z., 1982, Amygdalar noradrenergic and dopaminergic mechanisms in the regulation of hunger and thirst-motivated behavior, Brain Res. 233: 115–132.PubMedCrossRefGoogle Scholar
  12. Mason, S. T., and Fibiger, H. C., 1978, 6-OHDA lesion of the dorsal noradrenergic bundle alters extinction of passive avoidance, Brain Res. 152: 209–214.Google Scholar
  13. Nakano, Y., Lénârd, L., Oomura, Y., Nishino, H., Aou, S., and Yamamoto, T., 1987, Functional involvement of catecholamines in reward related neuronal activity of the monkey amygdala, J. Neurophysiol. 57: 7291.Google Scholar
  14. Nakano, Y., Oomura, Y., Lénârd, L., Nishino, H., Aou, S., Yamamoto, T., and Aoyagi, K., 1986, Feeding related activity of glucose and morphine sensitive neurons in the monkey amygdala, Brain Res. 399: 167172.Google Scholar
  15. Ono, T., Fukuda, M., Nishino, H., Sasaki, K., and Muramoto, K., 1983, Amygdaloid neuronal responses to complex visual stimuli in an operant feeding situation in the monkey, Brain Res. Bull. 11: 515–518.PubMedCrossRefGoogle Scholar
  16. Oomura, Y., Nishino, H., Aou, S., and Lenard, L., 1986, Opiate mechanism in reward-related neuronal responses during operant feeding behavior of the monkey, Brain Res. 365: 335–339.PubMedCrossRefGoogle Scholar
  17. Sanghera, M. K., Rolls, E. T., and Roper-Hall, A., 1979, Visual responses of neurons in the dorsolateral amygdala of the alert monkey, Exp. Neurol. 63: 610–626.PubMedCrossRefGoogle Scholar
  18. Wise, R. A., and Schwartz, H. V., 1981, Pimozide attenuates acquisition of lever-pressing for food in rats, Pharmacol. Biochem. Behay. 15: 655–656.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Yutaka Oomura
    • 1
    • 2
  • Yasuhiko Nakano
    • 2
  • László Lénárd
    • 2
  • Hitoo Nishino
    • 2
  • Shuji Aou
    • 2
  1. 1.Department of Physiology, Faculty of MedicineKyushu UniversityFukuoka 812Japan
  2. 2.Department of Biological Control SystemsNational Institute for Physiological SciencesOkazaki 444Japan

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