The Cellular Basis for Short-Term Memory in Endocrine Systems

  • Howard Rasmussen
  • Carlos Isales
  • Yoh Takuwa
  • Noriko Takuwa
  • Paula Barrett
  • Walter Zawalich


A common property of many endocrine systems is an anamnestic response. For instance, when pancreatic islets are reexposed to a standard glucose stimulus after a prior period of exposure to the same glucose challenge, their insulin secretory response is greater to the second than to the first stimulus (Gold et al., 1982; Grill et al., 1978, 1979; Grill and Rundfeldt, 1979; Grill, 1981; Grodsky et al., 1969). A similar pattern is seen on repeated exposure of adrenal glomerulosa cells to the peptide hormone angiotensin II. Recent work in both of these systems indicates that protein kinase C plays a central role in mediating the sustained phase of each of these endocrine responses (Kojima et al., 1984; Tanigawa et al., 1982; Zawalich et al., 1983, 1984). Work in our laboratories over the past 18 months has focused on the possible role of protein kinase C in this type of short-term cellular memory in bovine adrenal glomerulosa cells and isolated rat pancreatic islets.


Insulin Secretion Phosphatidic Acid None None Influx Rate Insulin Secretory Response 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Howard Rasmussen
    • 1
  • Carlos Isales
    • 1
  • Yoh Takuwa
    • 1
  • Noriko Takuwa
    • 1
  • Paula Barrett
    • 1
  • Walter Zawalich
    • 1
  1. 1.Departments of Internal Medicine and Cell Biology, School of Medicine and School of NursingYale UniversityNew HavenUSA

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