Filaggrins are a group of cationic, species-distinct proteins named for their ability to cause intermediate filament (IF) aggregation in vitro. Several types of intermediate filament associated proteins (IFAP) are now recognized and have been classified in a recent review (Steinert and Roop, 1988, and described elsewhere in this volume). Filaggrin was the first epidermal IFAP to be isolated, and is a readily studied example of this class of proteins. Various investigators have made significant progress on the protein structure and function. More recently, the cDNA has been used for studies of profilaggrin expression and gene structure.
KeywordsStratum Corneum Granular Layer Epidermal Differentiation Cornified Layer Keratin Filament
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