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Intermediate Filament-Associated Proteins

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Book cover Cellular and Molecular Biology of Intermediate Filaments

Abstract

Intermediate filaments (IF) comprise a set of ~ 10-nm-diameter cytoskeletal filaments that are distributed throughout the cytoplasm from the level of the nuclear surface to the region of the plasma membrane in most eukaryotic cells (Ishikawa et. al., 1968; Traub, 1985a; Wang et. al., 1985; Goldman et. al., 1986). While IF from the various vertebrate cells share certain structural characteristics and constitute a unique fibrous organelle (Pruss et. al., 1981; Fuchs and Hanukoglu, 1983; Steinert and Parry, 1985), the structural proteins comprising them can be classified into subgroups whose distribution in most cases is tissue-type specific (Goldman et. al., 1979; Lazarides, 1980; Steinert and Roop, 1988). Due to this tissue-type specificity, IF have been used as markers to determine the origin of cells in studies of differentiation and in clinical pathology, e.g., neoplasia (Osborn and Weber, 1982).

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, College of Medicine, University of Illinois, Chicago, Illinois, 60612, USA

    Hsi-Yuan Yang

  2. Department of Anatomy, Texas College of Osteopathic Medicine, Fort Worth, Texas, 76107, USA

    Norman Lieska

  3. Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Robert D. Goldman

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  1. Hsi-Yuan Yang
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  2. Norman Lieska
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  3. Robert D. Goldman
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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Robert D. Goldman

  2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Peter M. Steinert

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© 1990 Springer Science+Business Media New York

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Yang, HY., Lieska, N., Goldman, R.D. (1990). Intermediate Filament-Associated Proteins. In: Goldman, R.D., Steinert, P.M. (eds) Cellular and Molecular Biology of Intermediate Filaments. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9604-9_15

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  • DOI: https://doi.org/10.1007/978-1-4757-9604-9_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9606-3

  • Online ISBN: 978-1-4757-9604-9

  • eBook Packages: Springer Book Archive

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