Cell Fusion pp 123-144 | Cite as

Control of Membrane Fusion in Polyethylene Glycol-Resistant Cell Mutants

Applications to Fusion Technology
  • David S. Roos
  • Richard L. Davidson
  • Purnell W. Choppin


Cell fusion has been studied for more than A. century (Langerhans, 1868) as A. curious morphological phenomenon, occurring in certain developing tissues (Kalderon, 1980) and during the progression of A. variety of tumors and viral infections (Roizman, 1962; Guccion and Enzinger, 1972). Only with the use of cell hybrids in somatic cell genetics, however, did the impetus arise to develop fusion technology as an applied art, placing A. premium on the control of cell fusion (Davidson, 1977). The development of procedures for hybridoma production has made cell fusion A. fundamental tool of the growing biotechnology industry (Köhler and Milstein, 1975), and it is not surprising that improvements in the efficiency of cell hybridization protocols have been A. major goal in recent years (de St. Groth and Scheidegger, 1980).


Cell Fusion Fusion Partner Fatty Acyl Chain Fatty Acid Supplement Homogeneous Culture 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • David S. Roos
    • 1
  • Richard L. Davidson
    • 2
  • Purnell W. Choppin
    • 3
  1. 1.Department of BiologyStanford UniversityStanfordUSA
  2. 2.Center for GeneticsUniversity of IllinoisChicagoUSA
  3. 3.Virology LaboratoryRockefeller UniversityNew YorkUSA

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