Cell Fusion pp 421-426 | Cite as

The Early History of Mammalian Somatic Cell Fusion

  • John W. Littlefield


Probably the primary value of recounting the early history of any subject is to preserve for some future scholar a chronology and a bibliography that otherwise might be difficult to reconstruct. Accordingly, this brief review of the way in which the technique of mammalian cell fusion or hybridization originated includes both the key original papers and all the significant early reviews concerning this topic known to this author, from 1960, when experiments on fusion began, until about 1975. During the subsequent 10 years up to the present, the use of cell fusion techniques has been extensive and diverse, often in directions that were not apparent in 1975.


Somatic Cell Thymidine Kinase Somatic Hybrid Cell Fusion Hybrid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • John W. Littlefield
    • 1
  1. 1.Department of PhysiologyJohns Hopkins University School of MedicineBaltimoreUSA

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