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Cancer, Stress, and Death pp 63–77Cite as

Psychological Factors in the Causation and Course of Cancer

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Abstract

The influence of psychological factors on the development and course of cancer, long a topic of speculation, is now a subject of growing scientific interest. This chapter reviews relevant evidence from psychological studies of patients with (or at risk of) cancer, experiments with animal tumor models, and studies of the effects of stress on the neuroendocrine and immune systems.

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References

  1. Kowal, S.J., 1955, Emotions as a cause of cancer: Eighteenth and nineteenth century contributions, Psychoanal. Res. 42: 217–227.

    CAS  Google Scholar 

  2. Simonton, O.C., Matthews-Simonton, S., and Creighton, J., 1978, Getting Well Again: A Step-by-Step, Self-Help Guide to Overcoming Cancer for Patients and Their Families, J.P. Tarcher, Los Angeles.

    Google Scholar 

  3. Leshan, L.L., 1959, Psychological states as factors in the development of malignant disease: A critical review, J. Natl. Cancer Inst. 22: 1–18.

    PubMed  CAS  Google Scholar 

  4. Bacon, C.L., Renneker, R.E., and Cuten, M., 1952, A psychosomatic survey of cancer of the breast, Psychosom. Med. 14: 453–459.

    PubMed  CAS  Google Scholar 

  5. Blumberg, E.M., West, P.M., and Ellis, F.W., 1954, A possible relationship between psychological factors and human cancer, Psychosom. Med. 16: 276–286.

    Google Scholar 

  6. Krasnoff, A., 1959, Psychological variables and human cancer. A cross-validation study, Psychosom. Med. 21: 291–295.

    PubMed  CAS  Google Scholar 

  7. Greene, W.A., Jr., and Miller, G., 1958, Psychological factors in reticuloendothelial disease, Psychosom. Med. 20: 124–144.

    PubMed  Google Scholar 

  8. Reznikoff, M., 1955, Psychological factors in breast cancer, Psychosom. Med. 17: 96–105.

    PubMed  CAS  Google Scholar 

  9. Kissen, D.M., 1963, Personality characteristics in males conducive to lung cancer, Br. J. Med. Psychol. 36: 27–36.

    Article  PubMed  CAS  Google Scholar 

  10. Abse, D.W., Wilkins, M.M., Van de Castle, R.M., Buxton, W.D., Demars, J., Brown, E.A., and Kirschner, L.G., 1974, Personality and behavior characteristics of lung cancer patients, J. Psychosom. Res. 18: 101–113.

    Article  PubMed  CAS  Google Scholar 

  11. Schmale, A.H., and Iker, H., 1971, Hopelessness as a predictor of cervical cancer, Soc. Sci. Med. 5: 95–100.

    Article  PubMed  CAS  Google Scholar 

  12. Grissom, J.J., Weiner, B.J., and Weiner, E.A., 1975, Psychological correlates of cancer, J. Consult. Clin. Psychol. 43: 113.

    Article  PubMed  CAS  Google Scholar 

  13. Home, R.L., and Picard, R.S., 1979, Psychological risk factors for lung cancer, Psychosom. Med. 41: 503–513.

    Google Scholar 

  14. Muslin, H.L., Gyarfas, K., and Pieper, W.J., 1966, Separation experience and cancer of the breast, Ann. N.Y. Acad. Sci. 125: 802–806.

    Article  PubMed  CAS  Google Scholar 

  15. Watson, C.G., and Shuld, D., 1977, Psychosomatic factors in the etiology of neoplasms, J. Consult. Clin. Psychol. 45: 455–461.

    Article  PubMed  CAS  Google Scholar 

  16. Fox, B., 1978, Premorbid psychological factors as related to cancer incidence, J. Behay. Med. 1: 45–133.

    Article  CAS  Google Scholar 

  17. Wellisch, D.K., and Yager, J., 1983, Is there a cancer-prone personality? CA, 33: 145–153.

    PubMed  CAS  Google Scholar 

  18. Shrifte, M.L., 1962, Toward identification of a psychological variable in host resistance to cancer, Psychosom. Med. 24: 390–397.

    PubMed  CAS  Google Scholar 

  19. Stavraky, K.M., et al.,1968, Psychological factors in the outcome of human cancer, J. Psychosom. Res. 12:251–259.

    Google Scholar 

  20. Derogatis, L.R., Abeloff, M.D., and Melisarotos, N., 1979, Psychological coping mechanisms and survival time in metastic breast cancer, J. Am. Med. Assoc. 242: 1504–1508.

    Article  CAS  Google Scholar 

  21. Greer, S., Morris, T., and Pettingale, K.W., 1979, Psychological response to breast cancer: Effect on outcome, Lancet 2: 785–787.

    Article  PubMed  CAS  Google Scholar 

  22. Rogentine, G.N., Van Kammen, D.P., Fox, B.H., Docherty, J.P., Rosenblatt, J.E., Boyd, S.C., and Bunney, W.E., 1979, Psychosocial factors in the prognosis of malignant melanoma: A prospective study, Psychosom. Med. 41: 647655.

    Google Scholar 

  23. Funch, D.P., and Marshall, J., 1983, The role of stress, social support and age in survival from breast cancer, J. Psychosom. Res. 27: 77–83.

    Article  PubMed  CAS  Google Scholar 

  24. Hagnell, O., 1966, The premorbid personality of persons who develop cancer in a total population investigated in 1947 and 1957, Ann. N.Y. Acad. Sci. 125: 846–855.

    Article  PubMed  CAS  Google Scholar 

  25. Grossarth-Maticek, R., Siegrist, J., and Vetter, H., 1982, Interpersonal repression as a predictor of cancer, Soc. Sci. Med. 16: 493–498.

    Article  PubMed  CAS  Google Scholar 

  26. Thomas, C.B., Duszynski, K.R., and Shaffer, J.W., 1979, Family attitudes reported in youth as potential predictors of cancer, Psychosom. Med. 41: 287302.

    Google Scholar 

  27. Shekelle, R.B., Raynor, W.J., Jr., Ostfeld, A.M., Garron, D.C., Bieliauskas, L.A., Liu, S.C., Maliza, C., and Paul, O., 1981, Psychological depression and 17-year risk of death from cancer, Psychosom. Med. 43: 117–125.

    PubMed  CAS  Google Scholar 

  28. Niemi, T., and Jääskeläinen, J., 1978, Cancer morbidity in depressive persons, J. Psychosom. Res. 22: 117–120.

    Article  PubMed  CAS  Google Scholar 

  29. Keehn, R.J., Goldberg, I.D., and Beebe, G.W., 1974, Twenty four year mortality follow-up of army veterans with disability separations for psycho-neurosis in 1944, Psychosom. Med. 36: 27–46.

    PubMed  CAS  Google Scholar 

  30. Riley, V., 1975, Mouse mammary tumors: Alteration of incidence as apparent function of stress, Science 189: 465–467.

    Article  PubMed  CAS  Google Scholar 

  31. Levin, S., and Cohen, C., 1959, Differential survival to leukemia as a function of infantile stimulation in DBA 1/2 mice, Proc. Soc. Exp. Biol. Med. 102: 53–54.

    Google Scholar 

  32. Advervant, H.B., 1944, Influence of environment on mammary cancer in mice, Natl. Cancer Inst. Monogr. 4: 579–581.

    Google Scholar 

  33. Stern, J.A., Winokur, G., Graham, D.T., and Lefton, R., 1959, Effect of enforced activity stress on the development of experimental papillomas in mice, J. Natl. Cancer Inst. 23: 1013–1018.

    PubMed  CAS  Google Scholar 

  34. Van den Brenk, H.A.S., Stone, M.G., Kelly, H., and Sharpington, C., 1976. Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress, Br. J. Cancer 33: 60–78.

    Article  Google Scholar 

  35. Peters, L.J., and Kelly, H., 1977, The influence of stress and stress hormones on the transplantability of a non-immunogenic syngeneic murine tumor, Cancer 39: 1482–1488.

    Article  PubMed  CAS  Google Scholar 

  36. Ebbes, P., and Rask-Kielsen, R., 1967, Influence of sex-segregated grouping and of inoculation of subcellular leukemia material on development of non-leukemic lesions in DBA/2, BALB/C, and CBA mice, J. Natl. Cancer Inst. 39: 917–925.

    Google Scholar 

  37. Sing-Mao, L., 1963, Effect of neurosis on appearance and development of induced mammary gland tumors in rats, Fed. Proc. Trans!. Suppl. 22: 1241–1244.

    CAS  Google Scholar 

  38. Sklar, L.S., Bruto, V., and Anisman, H., 1981, Adaptation to the tumor enhancing effects of stress, Psychosom. Med. 43: 331–342.

    PubMed  CAS  Google Scholar 

  39. Riley, V., 1981, Neuroendocrine influences on immunocompetence and neoplasia, Science 212: 1100–1109.

    Article  PubMed  CAS  Google Scholar 

  40. Gross, W., 1972, Effect of social stresses on occurrence of Marek’s disease in chickens, Am. J. Vet. Res. 33: 2275–2279.

    PubMed  CAS  Google Scholar 

  41. Henry, J., Stephens, P., and Watson, R., 1975, Force breeding, social disorder and mammary tumor formation in CBA/USC mouse colonies: A pilot study, Psychosom. Med. 37: 277–283.

    PubMed  CAS  Google Scholar 

  42. Birkeland, S.A., 1983, Malignant tumor in renal transplant patients: The Scan-dia transplant material, Cancer 51: 1571–1575.

    Article  PubMed  CAS  Google Scholar 

  43. Kaliss, N., and Fuller, J.L., 1968, Incidence of lymphatic leukemia and methylcholanthene-induced cancer in laboratory mice subjected to stress, J. Natl. Cancer Inst. 41: 967–983.

    PubMed  CAS  Google Scholar 

  44. Ader, R., and Friedman, S.B., 1965, Differential early experiences and susceptibility to transplanted tumors in the rat, J. Comp. Physiol. Psychol. 59: 361–364.

    Article  CAS  Google Scholar 

  45. Ray, P., and Pradham, S.N., 1974, Brief communication: Growth of transplanted and induced tumors in rats under a schedule of punished behavior, J. Natl. Cancer Inst. 52: 575–577.

    PubMed  CAS  Google Scholar 

  46. Gershben, L.L., Benuck, I., and Shurrsger, P.S., 1974, Influence of stress on lesion growth and on survival of animals bearing parenteral and intracerebral leukemia L1210 and Walker tumors, Oncology 30: 429–435.

    Article  Google Scholar 

  47. Newberry, B.H., Goldow, J., Wogden, J., and Reese, R.L., 1976, Inhibition of Huggins tumors by forced restraint, Psychosom. Med. 38: 155–162.

    PubMed  CAS  Google Scholar 

  48. Amkraut, A.A., and Solomon, G.F., 1972, Stress and murine sarcoma virus (Maloney)-induced tumors, Cancer Res. 32: 1428–1433.

    PubMed  CAS  Google Scholar 

  49. Vistintaner, M.A., Volpicelli, J.R., and Seligman, M.E., 1982, Tumor rejection in rats after inescapable or escapable shock, Science 216: 437–439.

    Article  Google Scholar 

  50. Ader, R. (ed.), 1981, Psychoneuroimmunology, Academic Press, New York.

    Google Scholar 

  51. Locke, S., and Horning-Rohan, M. (eds.), 1983, Mind and Immunity: Behavioral Immunology (1976–1982), Institute for the Advancement of Health, New York.

    Google Scholar 

  52. Fox, B.H., and Newberry, B.H. (eds.), 1984, Impact of Psychoendocrine Systems in Cancer and Immunology, C.J. Hogrefe, Lewiston, New York.

    Google Scholar 

  53. Solomon, G.F., and Amkraut, A.A., 1981, Psychoneuroendocrinological effects on the immune system, Annu. Rev. Microbiol. 35: 155–184.

    Article  PubMed  CAS  Google Scholar 

  54. Borysenko, M., and Borysenko, J., 1981, Stress, behavior and immunity: Animal models and mediating mechanisms, Gen. Hosp. Psychiatry 4: 59–67.

    Article  Google Scholar 

  55. Locke, S.E., 1982, Adaptation and immunity studies in humans, Gen. Hosp. Psychiatry 4: 49–58.

    Article  PubMed  CAS  Google Scholar 

  56. Cannon, W.B., 1926, The emergency function of the adrenal medulla in pain and the major emotions, Am. J. Physiol. 33: 356–372.

    Google Scholar 

  57. Brown, G.M., and Reichlin, S., 1972, Psychologie and neural regulation of growth hormone secretion, Psychosom. Med. 34: 45–61.

    PubMed  CAS  Google Scholar 

  58. Hirata, Y., Sakamoto, N., Matsukura, S., and Imura, H., 1975, Plasma levels of beta-MSH and ACTH during acute stresses and metapyrone administration in man, J. Clin. Endocrinol. Metab. 41: 1092–1097.

    Article  PubMed  CAS  Google Scholar 

  59. Mason, J.W., 1968, A review of psychoendocrine research on the pituitary adrenal cortical system, Psychosom. Med. 30: 576–607.

    PubMed  Google Scholar 

  60. Noel, G.L., Suh, H.K., Stone, G., and Frantz, A.G., 1972, Human prolactin and growth hormone release during surgery and other conditions of stress, J. Clin. Endocrinol. Metab. 35: 840–851.

    Article  PubMed  CAS  Google Scholar 

  61. Dewhurst, K.E., El Kabir, D.J., Harris, G.W., and Mandelbrote, B.M., 1968, A review of the effect of stress on the activity of the central nervous-pituitary-thyroid axis in animals and man, Conlin. Neurol. 30: 161–174.

    CAS  Google Scholar 

  62. Landsberg, L., 1977, The sympathoadrenal system, in: The Year in Endocrinology, 1977 ( S.H. Ingbar, ed.), Plenum Press, New York, pp. 355–358.

    Google Scholar 

  63. Claman, H.N., 1977, Corticosteroids and lymphoid cells, N. Engl. J. Med. 287: 388–397.

    Article  Google Scholar 

  64. Bourne, H.R., Lichtenstein, L.M., Melman, R.L., Henney, C.S., Weinstein, Y., and Shearer, G.M., 1974, Modulation of inflammation and immunity by cyclic AMP, Science 184: 19–28.

    Article  PubMed  CAS  Google Scholar 

  65. Dougherty, T.F., Berliner, M.L., Schneebeli, G.L., and Berliner, D.L., 1964, Hormonal control of lymphatic structure and function, Ann. N.Y. Acad. Sci. 113: 825–843.

    Article  PubMed  CAS  Google Scholar 

  66. Luparello, T.J., Stein, M., and Park, C.D., 1964, Effect of hypothalamic lesions on rat anaphylaxis, Am. J. Physiol. 207: 911–914.

    PubMed  CAS  Google Scholar 

  67. Stein, M., Schiavi, R.C., and Camerino, M., 1976, Influence of brain and behavior on the immune system, Science 191: 435–440.

    Article  PubMed  CAS  Google Scholar 

  68. Korneva, E.A., and Khai, L.M., 1963, Effect of destruction of hypothalamic areas on immunogenesis, Fiziol. Zh. SSSR. 49: 42–48.

    PubMed  CAS  Google Scholar 

  69. Williams, J.M., Peterson, R.G., Shea, P.A., Schmedtje, J.C., Bauer, D.C., and Felten, D.L., 1981, Sympathetic innervation of murine thymus and spleen: Evidence for a functional link between the nervous and immune system, Brain Res. Bull. 6: 83–94.

    Article  PubMed  CAS  Google Scholar 

  70. Adler, R., andCohen, N., 1974, Behaviorally conditioned immunosuppression, Psychosom. Med. 37: 333–340.

    Google Scholar 

  71. Rogers, M.P., Reich, P., Strom, T.B., and Carpenter, C.B., 1976, Behaviorally conditioned immunosuppression: Replication of a recent study, Psychosom. Med. 38: 447–451.

    PubMed  CAS  Google Scholar 

  72. Marsh, J.T., and Rasmussen, A.F., Jr., 1960, Responses of adrenals, thymus, spleen and leucocytes to shuttle box and confinement stress, Proc. Soc. Exp. Biol. Med. 104: 180–183.

    PubMed  CAS  Google Scholar 

  73. Bartrop, R W, Lazarus, L., Luckhurst, E., Kiloh, L.G., and Penny, R., 1977, Depressed lymphocyte function after bereavement, Lancet 1: 834–836.

    Article  PubMed  CAS  Google Scholar 

  74. Schleifer, S.J., Keller, S.E., Camerino, M., Thornton, J.C., and Stein, M., 1983, Suppression of lymphocyte stimulation following bereavement, J. Am. Med. Assoc. 250: 374–377.

    Article  CAS  Google Scholar 

  75. Schleifer, J.J., Kieller, S.E., Siris, S., Davis, K.L., and Stein, M., 1985, Depression and immunity, Arch. Gen. Psych. 42: 129–133.

    Article  CAS  Google Scholar 

  76. Kasl, S.V., Evans, A.S., and Niederman, J.C., 1979, Psychosocial risk factors in the development of infectious mononucleosis, Psychosom. Med. 41: 445–466.

    PubMed  CAS  Google Scholar 

  77. Cohen-Cole, S., Cogen, R., Stevens, A., Kirk, K., Gartan, E., Hain, J., and Freedman, A., 1981, Psychosocial, endocrine, and immune factors in acute necrotizing ulcerative gingivitis (“trenchmouth”) (Abstract), Psychosom. Med. 43: 91.

    Google Scholar 

  78. Locke, S.E., Kraus, L., Leserman, J., Hurst, M.W., Heisel, J.J., and Williams, R.M., 1984, Life change stress, psychiatric symptoms and natural killer cell activity, Psychosom. Med. 46: 441–453.

    PubMed  CAS  Google Scholar 

  79. Rogers, M.P., Dubey, D., and Reich, P., 1979, The influence of the psyche and the brain on immunity and disease susceptibility: A critical review, Psychosom. Med. 41: 147–164.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    John R. Peteet M.D.

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  1. John R. Peteet M.D.
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Editors and Affiliations

  1. International Center for Health Sciences, Meharry Medical College, 37208, Nashville, Tennessee, USA

    Stacey B. Day M.D., Ph.D., D.Sc. (Professor of International Health and Director, Formerly Professor and Member) (Professor of International Health and Director, Formerly Professor and Member)

  2. Sloan-Kettering Institute for Cancer Research, 10021, New York, New York, USA

    Stacey B. Day M.D., Ph.D., D.Sc. (Professor of International Health and Director, Formerly Professor and Member) (Professor of International Health and Director, Formerly Professor and Member)

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Peteet, J.R. (1986). Psychological Factors in the Causation and Course of Cancer. In: Day, S.B. (eds) Cancer, Stress, and Death. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9573-8_5

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  • DOI: https://doi.org/10.1007/978-1-4757-9573-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9575-2

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