Stress, the Immune System, and Cancer

  • George W. Wermers
  • Jai Dev Dasgupta
  • Devendra P. Dubey


A casual linkage between stress and susceptibility to infectious disease and cancer has been suggested for some time. It has further been proposed that such a relationship, if it is a meaningful one, probably involves the influence of stress on immune system function.


Firing Rate Lymphoid Organ Opioid Peptide Neuroendocrine System Immune System Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lewis, M.G., and Phillips, T.M., 1979, The possible effects of emotional stress on cancer mediated through the immune system, in: Cancer, Stress, and Death U. Taché, H. Selye, and S.B. Day, eds.), Sloan-Kettering Institute Cancer Series, Plenum Medical, New York and London.Google Scholar
  2. 2.
    Marx, J.L., 1985, The immune system “belongs in the body,” Science 227: 1190–1192.PubMedCrossRefGoogle Scholar
  3. 3.
    Erlich, P., 1909, Ueber den Jetzigen, Stand der Karzinom, Forschung, Ned. Tijdschr. Geneesk. 53: 273–298.Google Scholar
  4. 4.
    Thomas, L., 1959, In: Cellular and Humoral Aspects of the Hypersensitive State, (H.S. Lawrence, ed.), Harper, New York, p. 529.Google Scholar
  5. 5.
    Burnett, F.M., 1979, The concept of immunological surveillance, Proc. Exp. Tumor Res. 13: 1–27.Google Scholar
  6. 6.
    Cooper, G.M., 1982, Cellular transforming genes, Science 218: 801–806.CrossRefGoogle Scholar
  7. 7.
    Klein, G. and Klein, E. 1985, Evolution of tumors and the impact of molecular oncology, Nature 315: 190–195.PubMedCrossRefGoogle Scholar
  8. 8.
    Green, D.R., Flood, P.M., and Gershon, R.K., 1983, Immunoregulatory T-cell pathways, Ann. Rev. Immunol. 1: 439–463.CrossRefGoogle Scholar
  9. 9.
    Dorf, M.E., and Benacerraf, B., 1984, Suppressor cells and immunoregulation. Ann. Rev. Immunol. 2: 127–158.CrossRefGoogle Scholar
  10. 10.
    Francke U., and Pellegrino, M.A., 1977, Assignment of the major histocompatibility complex to a region of the short arm of chromosome 6, Proc. Natl. Acad. Sci. USA 74: 1147–1152.PubMedCrossRefGoogle Scholar
  11. 11.
    Benacerraf, B., and Katz, D., 1975, The histocompatibility-linked immune response genes, Adv. Cancer Res. 21: 121–173.PubMedCrossRefGoogle Scholar
  12. 12.
    Cantor, H., and Boyse, E.A., 1975, Functional subclasses of T-lymphocytes bearing different Ly antigens II. Cooperation between subclasses of Ly and Ly+ cells in the generation of killer activity, J. Exp. Med. 141: 1390–1399.PubMedCrossRefGoogle Scholar
  13. 13.
    Smith, K.A., Lachman, L.B., Oppenheim, J.J., and Favata, M.F., 1980, The functional relationship of the interleukin, J. Exp. Med. 151: 1551.PubMedCrossRefGoogle Scholar
  14. 14.
    Gilman, S.C., Schwartz, J.M., Milner, R.J., Bloom, F.E., and Feldman, J.D., 1982, Beta-endorphin enhances lymphocyte proliferative responses, Proc. Natl. Acad. Sci. USA 79: 4226–4231.PubMedCrossRefGoogle Scholar
  15. 15.
    Herberman, R.B., and Ortaldo, J.R., 1981, Natural killer cells: Their role in defenses against disease, Science 214: 24–30.PubMedCrossRefGoogle Scholar
  16. 16.
    Trinchieri G., and Perussia, B., 1985, Immune interferon: A pleiotropic lympholine with multiple effects, Immunol. Today 6: 131–135.CrossRefGoogle Scholar
  17. 17.
    Klein, G., 1974, Immunological surveillance against neoplasia, Harvey Lectures, New York.Google Scholar
  18. 18.
    Smith, G.S., and Walford, R.L., 1978, Influence of the H-2 and H-1 histocompatibility systems upon life span and spontaneous cancer incidences in cogenic mice, in: Genetic Effects of Aging ( D. Bergsma and D. Harrison, eds.), Alan R. Liss, New York.Google Scholar
  19. 19.
    Hallgren, Jim, Kersey, J.H., Dubey, D.P., and Yunis, E.J., 1978, Lymphocyte subsets and integrated immune function in aging humans, Clin. Immuno. Immunopath. 10: 65–78.CrossRefGoogle Scholar
  20. 20.
    Spector, H. N., 1983, Anatomical and physiological connections between the central nervous system and immune systems (Neuroimmune-modulation), in: Immunoregulation, ( Fabris, N., Garaci, E., Hadden, J., Michison, N. A., eds.), Plenum, New York.Google Scholar
  21. 21.
    Williams, J.M., and Felten, D.L., 1981, Sympathetic innervation of mutine thymus and spleen: A comparative histofluorescence study, Anat. Rec. 199: 531–542.PubMedCrossRefGoogle Scholar
  22. 22.
    Bullock, K., and Moore, R.Y., 1981, Innervation of the thymus gland by brain stem and spinal cord in mouse and rat, Am. J. Anat. 162: 157–166.CrossRefGoogle Scholar
  23. 23.
    Bullock, K., and Pomerantz, W., 1984, Autonomic nervous system innervation of thymic-related lymphoid tissue in wildtype and nude mice, J. Comp. Neurol. 228: 57–68.CrossRefGoogle Scholar
  24. 24.
    Besedovsky, H.O., del Rey, A.E., and Sorkin, E., 1983. What do the immune system and the brain know about each other? Immunol. Today 4: 342–346.CrossRefGoogle Scholar
  25. 25.
    Besedovsky, H., and Sorkin, E., 1977, Network of immune-neuroendocrine interactions, Clin. Exp. Immunol. 27: 1–12.PubMedGoogle Scholar
  26. 26.
    Besedovsky, H.O., del Rey, A., and Sorkin, E., 1983. Neuroendocrine immunoregulation, in: Immunoregulation ( W. Fabris, E. Garaci, J. Hadden, and N.A. Michison, eds.), Plenum, New York, pp. 315–339.CrossRefGoogle Scholar
  27. 27.
    Besedovsky, H., del Rey, A., DaPrada, M., Burri, R., and Honegger, 1983, The immune response evokes changes in brain noradrenergic neurons, Science 221: 564–566.PubMedCrossRefGoogle Scholar
  28. 28.
    Besedovsky, H.D., del Rey, A., Sorkin, E., Lotz, W., and Schwulera, U., 1985, Lymphoid cells produce an immunoregulatory glucocorticoid increasing factor (GIF) acting through the pituitary gland, Clin. Exp. Immunol. 59: 622–628.PubMedGoogle Scholar
  29. 29.
    Williams, J.M., Peterson, R.G., Shea, P.A., Schmedje, J.F., Bauer, D.C., and Felton, D.L., 1981, Sympathetic innervation of mutine thymus and spleen: Evidence for a functional link between the nervous and immune systems, Brain Res. Bull. 63: 83–94.CrossRefGoogle Scholar
  30. 30.
    Blalock, J.E., and Smith, E.M., 1985, A complete regulatory loop between the immune and neuroendocrine systems, Fed. Proc. 44: 108–111.PubMedGoogle Scholar
  31. 31.
    Blalock, J.E., 1984, The immune system as a sensory organ, J. Immunol. 132: 1067–1070.PubMedGoogle Scholar
  32. 32.
    Smith, E.M., and Blalock, J.E., 1982, The hormonal nature of the interferon system, Texas Rep. Biol. Med. 41: 350–358.Google Scholar
  33. 33.
    Smith, E.M., Meyer, W.J., and Blalock, J.E., 1982, Virus-induced corticosterone in hypophysectomized mice. A possible lymphoid adrenal axis, Science 218: 1311–1312.PubMedCrossRefGoogle Scholar
  34. 34.
    Johnson, H.M., Smith, E.M., Torres, B.A., and Blalock, J.E., 1982, Regulation of the in vitro antibody response by neuroendocrine hormones, Proc. Natl. Acad. Sci. USA 79: 4171–4174.PubMedCrossRefGoogle Scholar
  35. 35.
    Wybran, J., 1985, Enkephalins and endorphins as modifiers of the immune system: Present and Future, Fed. Proc. 44: 92–94.PubMedGoogle Scholar
  36. 36.
    Hazum, E., Chang, K.J., and Cuatrecasas, P., 1979, Specific nonopiate receptors for p-endorphins, Science 205: 1033–1035.PubMedCrossRefGoogle Scholar
  37. 37.
    Mathews, P.M., Froelich, C.J., Sibbitt, W.L., Jr., and Bankhurst, A.D., 1983, Enhancement of natural cytotoxicity by p-endorphin, J. Immunol. 130: 1658 1662.Google Scholar
  38. 38.
    Plotnikoff, N.P., and Miller, G.C., 1983, Enkephalins as immunomodulators, Int. J. Immunopharmacol. 5: 437–441.PubMedCrossRefGoogle Scholar
  39. 39.
    Plotnikoff, N.P., Murgo, A.J., Miller, G.C., Corder, C.M., and Faith, R.E., 1985, Enkephalins: Immunomodulators, Fed. Proc. 44: 118–122.PubMedGoogle Scholar
  40. 40.
    Hanbauer, I., Kelly, G.D., Saiani, L., and Yang, H.Y.T., 1982, (Met5)-Enkephalin-like peptides of the adrenal medulla: Release by nerve stimulation and functional implications, Peptides 3: 469–473.Google Scholar
  41. 41.
    Amir, S., Brown, Z.W., and Amit, Z., 1980, The role of endorphins in stress: Evidence and speculations, Neurosci. Biobehay. Rev. 4: 77–86.CrossRefGoogle Scholar
  42. 42.
    Brown, M.R., Fischer, L.A., 1985, Corticotropin-releasing factor: Effects on the autonomic nervous and visceral systems, Fed. Proc. 44: 243–248.PubMedGoogle Scholar
  43. 43.
    Riley, V., 1981, Psychoneuroendocrine influences on immunocompetence and neoplasia, Science 212: 1100–1109.PubMedCrossRefGoogle Scholar
  44. 44.
    Day, S.B., Yunis, E.J., and Dubey, D.P., 1981, An overview of stress and the immune system, in: Social Pediatrics ( R.J. Schlegel, ed.), International Foundation for Biosocial Development and Human Health (including the Biopsychosocial Health Society), New York, pp. 69–81.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • George W. Wermers
    • 1
  • Jai Dev Dasgupta
    • 1
  • Devendra P. Dubey
    • 1
  1. 1.Division of Immunogenetics, Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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