Pharmacokinetic Comparison Between L & D, L-BPA. Fructose in a Murine Melanoma Model and in Human Patients with Metastatic Melanoma
Various drugs have been developed and trialed for boron neutron capture therapy (BNCT) but p-borono-phenylalanine (BPA) is one of the most successful compounds to date. BPA was originally developed as a selective targeting drug for BNCT of brain tumours on the basis that cancer cells require increased quantities of amino acids in order to maintain their faster metabolism compared to normal cells.1 Melanoma cells actively transport and metabolise aromatic amino acids such as phenylalanine and tyrosine for use as precursors in the synthesis of the pigment, melanin. BPA, being a phenylalanine derivative, is believed to exploit this mechanism resulting in the selective uptake in melanoma tumours and the successful application of BNCT in animals and some human patients.2–5
KeywordsMetastatic Melanoma Boron Concentration Boronic Acid Boron Neutron Capture Therapy Selective Uptake
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