Boron Analytical Studies on 10B1-BPA Administration for Neutron Capture Therapy of Malignant Melanoma

  • C. Honda
  • N. Wadabayashi
  • K. Yoshino
  • J. Hiratsuka
  • H. Karashima
  • T. Kobayashi
  • H. Fukuda
  • M. Ichihashi
  • Y. Mishima

Abstract

Success of boron neutron capture therapy (NCT) for cancer depends mainly upon selective boron accumulation in the targeted tumor. Since 1987 we have succeeded in treating human melanoma lesions by NCT utilizing10B1-para-boronophenylalanine (10B1-BPA).1 At the same time we have investigated various methods of administering10B1-BPA for optimal NCT. The results of our analytical studies on boron kinetics in animals and humans by 10B1-BPA administration are described.

Keywords

Boron Concentration Boron Neutron Capture Therapy Syrian Golden Hamster Chemical Assay High Boron Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • C. Honda
    • 1
  • N. Wadabayashi
    • 2
  • K. Yoshino
    • 3
  • J. Hiratsuka
    • 4
  • H. Karashima
    • 5
  • T. Kobayashi
    • 6
  • H. Fukuda
    • 7
  • M. Ichihashi
    • 2
  • Y. Mishima
    • 8
  1. 1.Department of DermatologyKakogawa Hosp.Hyogo Pref.Japan
  2. 2.Department of DermatologyKobe University School of Med.Japan
  3. 3.Department of ChemistryShinshu UniversityJapan
  4. 4.Department of RadiologyKawasaki Med. SchoolJapan
  5. 5.Regional Hygiene Div.Charged Particle TreatmentHyogo Pref. GovernmentJapan
  6. 6.Research Reactor Inst.Kyoto UniversityJapan
  7. 7.Department of Nucl. Med. and RadiologyTohoku UniversityJapan
  8. 8.Dermatological ResearchMishima Inst.Japan

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