Re-Evaluation of Skin RBE for Clinical BNCT of Malignant Melanoma

  • Junichi Hiratsuka
  • Hiroshi Fukuda
  • Tooru Kobayashi
  • Hiroshi Karashima
  • Kazuo Yoshino
  • Chihiro Honda
  • Nobutoshi Wadabayashi
  • Yutaka Mishima

Abstract

Due to the wide variation in biological systems, criteria, dose, and experimental conditions used to determine relative biological effectiveness (RBE) it is necessary to re-evaluate the experimental RBE for human treatment. In this paper, the biological effect of 10B-neutron capture therapy (BNCT) on human skin is re-evaluated based on the skin RBE value of hamsters.

Keywords

Boron Neutron Capture Therapy Relative Biological Effectiveness Calculated Dose Moist Desquamation Thermal Neutron Fluences 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. Ichihashi, T. Nakanishi and Y. Mishima, Specific killing effect of 15B-para-horonophcnylalanine in thermal neutron capture therapy of malignant melanoma: In vitro radiological evaluation, J. Invest. l)ermatol. 78: 215–218, 1982.CrossRefGoogle Scholar
  2. 2.
    J. Hiratsuka, H., Fukuda, T. Kobayashi, H. Karashima, K. Yoshino, Y. Imajo and Y. Mishima, The relative biological effectiveness of 1iB-neutron capture therapy of early skin reaction in the hamster, Radial. Res. 128: 186–191, 1991.CrossRefGoogle Scholar
  3. 3.
    Y. Mishima, C. Honda, M. Ichihashi, I1. Ohara, J. Hiratsuka, I I. Fukuda. H. Karashima. 1. Kobayashi, K. Kanda and K. Yoshino, Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 1°B-compound, Lancet 12: 388–389, 1980.Google Scholar
  4. 4.
    H. Fukuda, K. Ando, C. Honda, M. Ichihashi, Y. Mishima, J. Hiratsuka. T. Kobayashi and K. Kanda, Tolerance limits of the normal skin treated by a single thermal neutron capture therapy, in “Progress in Neutron Capture Therapy for Cancer,” B. J. Allen, D. L. Moore und B. V. I larrington, eds., Plenum Press. New York, 1992, pp. 511–514.Google Scholar
  5. 5.
    K. Kanda, Lithium fluoride tile and sheet for neutron shield, J. At. Ener~r Soc., Japan 20: 37–41, 1978.CrossRefGoogle Scholar
  6. 6.
    S. R. Tamat, D. E. Moore and B. J. Allen, Determination of boron in biological tissue by inductively coupled plasma atomic emission spectrometry,.final. Chem. 59i2161–2164. 1987_Google Scholar
  7. 7.
    K. Yoshino, M. Okamoto, K. Kakihana, T. Nakanishi, M. Ichihashi and Y. Mishima, Spectrophotometric determination of trace boron in biological material after alkali fusion decomposition, Anal. Chem. 56: 839–842, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    H. Fukuda, J. Hiratsuka, C. Honda, T. Kobayashi, K. Yoshino, H. Karashima, J. Takahashi, Y. Abe, K. Kanda, M. Ichihashi and Y. Mishima, Boron neutron capture therapy of malignant melanoma using 1°B-Para-boronophenylalanine with special reference of evaluation of radiation dose and damage to the normal skin, Radiat. Res. 138: 435–442, 1994.PubMedCrossRefGoogle Scholar
  9. 9.
    R. G. Fairchild and L. J. Goodman, Development and dosimetry of an “epithermal” neutron beam for possible use in neutron capture therapy, Phys. Med. Biol. 2: 15–30, 1966.CrossRefGoogle Scholar
  10. 10.
    M. Strandqvist, Studien uber die kumulative wirkung der roentgenstrahlen bei fractionierung, Acta. Radiol. Suppl. 55: 1–293, 1944.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Junichi Hiratsuka
    • 1
  • Hiroshi Fukuda
    • 2
  • Tooru Kobayashi
    • 3
  • Hiroshi Karashima
    • 4
  • Kazuo Yoshino
    • 5
  • Chihiro Honda
    • 6
  • Nobutoshi Wadabayashi
    • 6
  • Yutaka Mishima
    • 7
  1. 1.Department of RadiologyKawasaki Medical SchoolJapan
  2. 2.Department of Nuclear Medicine and Radiology Institute of DevelopmentAging and Cancer Tohoku UniversityJapan
  3. 3.Kyoto University Research Reactor InstituteJapan
  4. 4.Hyogo Medical CenterJapan
  5. 5.Department of Chemistry, Faculty of ScienceShinshu UniversityJapan
  6. 6.Department of DermatologyKobe University School of MedicineJapan
  7. 7.Mishima Institute for Dermatological ResearchJapan

Personalised recommendations