BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy

  • Hiroshi Fukuda
  • Yutaka Mishima
  • Jun’ichi Hiratsuka
  • Chihiro Honda
  • Nobutoshi Wadabayashi
  • Tooru Kobayashi
  • Kazuo Yoshino
  • Hiroshi Karashima
  • Jutaro Takahashi
  • Yoshinao Abe
  • Keiji Kanda
  • Masamitsu Ichihashi

Abstract

Research on selective melanoma neutron capture therapy was initiated by Y. Mishima and his associates, consisting of physicists, chemists, pharmacologists, radiobiologists, and medical scientists. Following basic research of 13 years, this team started the first clinical. trial of melanoma BNCT using10B-paraboronophenylalanine (BPA) in 1987 and have treated 16 patients with various types of melanoma1−4.

Keywords

Maximum Tolerable Dose Neutron Irradiation Complete Regression Conventional Radiotherapy Boron Neutron Capture Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hiroshi Fukuda
    • 1
  • Yutaka Mishima
    • 2
  • Jun’ichi Hiratsuka
    • 3
  • Chihiro Honda
    • 4
  • Nobutoshi Wadabayashi
    • 4
  • Tooru Kobayashi
    • 5
  • Kazuo Yoshino
    • 6
  • Hiroshi Karashima
    • 7
  • Jutaro Takahashi
    • 1
  • Yoshinao Abe
    • 1
  • Keiji Kanda
    • 5
  • Masamitsu Ichihashi
    • 4
  1. 1.Department of Nuclear Medicine and Radiology Institute of Development, Aging and CancerTohoku UniversityJapan
  2. 2.Mishima Institute for Dermatological ResearchJapan
  3. 3.Department of RadiologyKawasaki Medical SchoolJapan
  4. 4.Department of DermatologyKobe University School of MedicineJapan
  5. 5.Research Reactor InstituteKyoto UniversityJapan
  6. 6.Department of Chemistry, Faculty of ScienceShinsyu UniversityJapan
  7. 7.Department of RadiologyHyogo Prefectural Cancer CenterJapan

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