Binding and Immunohistochemical Localization of Na2B12H11SH to Tumor Tissue of Glioma Patients in Boron Neutron Capture Therapy

  • Birte Otersen
  • Dietrich Haritz
  • Frank Grochulla
  • Markus Bergmann
  • Walter Sierralta
  • Detlef Gabel


Boron neutron capture therapy (BNCT) is a radiation treatment modality for tumors. Prerequisite for successful therapy is the accumulation of boron in tumor tissue to a larger extent than in the surrounding normal tissue. Upon exposure to thermal neutrons, the boron-10 nucleus will undergo a neutron capture reaction; the resulting particles will then be responsible for cell death. The therapy is greatly influenced by the localization, on a subcellular scale, of boron.


Neutron Capture Boron Concentration Boron Neutron Capture Therapy Relative Biological Effectiveness Human Brain Tumor 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Birte Otersen
    • 1
  • Dietrich Haritz
    • 2
  • Frank Grochulla
    • 3
  • Markus Bergmann
    • 4
  • Walter Sierralta
    • 5
  • Detlef Gabel
    • 1
  1. 1.Department of ChemistryUniversity of BremenBremenGermany
  2. 2.Department of NeurosurgeryUniversity of HamburgGermany
  3. 3.Department of NeurosurgeryZKHBremenGermany
  4. 4.Institute of NeuropathologyZKHBremenGermany
  5. 5.Max-Planck-Institute for Experimental EndocrinologyHannoverGermany

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