Binding and Immunohistochemical Localization of Na2B12H11SH to Tumor Tissue of Glioma Patients in Boron Neutron Capture Therapy
Boron neutron capture therapy (BNCT) is a radiation treatment modality for tumors. Prerequisite for successful therapy is the accumulation of boron in tumor tissue to a larger extent than in the surrounding normal tissue. Upon exposure to thermal neutrons, the boron-10 nucleus will undergo a neutron capture reaction; the resulting particles will then be responsible for cell death. The therapy is greatly influenced by the localization, on a subcellular scale, of boron.
KeywordsNeutron Capture Boron Concentration Boron Neutron Capture Therapy Relative Biological Effectiveness Human Brain Tumor
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