Binding and Immunohistochemical Localization of Na2B12H11SH to Tumor Tissue of Glioma Patients in Boron Neutron Capture Therapy

  • Birte Otersen
  • Dietrich Haritz
  • Frank Grochulla
  • Markus Bergmann
  • Walter Sierralta
  • Detlef Gabel

Abstract

Boron neutron capture therapy (BNCT) is a radiation treatment modality for tumors. Prerequisite for successful therapy is the accumulation of boron in tumor tissue to a larger extent than in the surrounding normal tissue. Upon exposure to thermal neutrons, the boron-10 nucleus will undergo a neutron capture reaction; the resulting particles will then be responsible for cell death. The therapy is greatly influenced by the localization, on a subcellular scale, of boron.

Keywords

Neutron Capture Boron Concentration Boron Neutron Capture Therapy Relative Biological Effectiveness Human Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Birte Otersen
    • 1
  • Dietrich Haritz
    • 2
  • Frank Grochulla
    • 3
  • Markus Bergmann
    • 4
  • Walter Sierralta
    • 5
  • Detlef Gabel
    • 1
  1. 1.Department of ChemistryUniversity of BremenBremenGermany
  2. 2.Department of NeurosurgeryUniversity of HamburgGermany
  3. 3.Department of NeurosurgeryZKHBremenGermany
  4. 4.Institute of NeuropathologyZKHBremenGermany
  5. 5.Max-Planck-Institute for Experimental EndocrinologyHannoverGermany

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