ESR Study of Hydroxyl Radicals, Superoxide Anion Radicals and Molecular Singlet Oxygen Generated by Mercaptoundecahydro-closo-Dodecaborate(2-) Solution Irradiated by Neutrons under Conditions of Boron Neutron Capture Reaction

  • Pavel Stopka
  • Jiří Burian
  • Oldřich Štrouf


Recently, we have reported the generation of superoxide anion-radicals by neutron irradiation and UV light irradiation of mercaptoborates in water solutions at room temperature1. Now, we have irradiated 2.10-3 molar aqueous solutions of two types of mercaptoborates: Na2B12H11SH, [N(CH3)4]2B12H11SH and, for comparison Na2B4O7by thermal neutron flux on LVR-15 reactor in Řež/Czech Rep./ with total doses 5 Gy and 18 Gy, respectively. The generation of hydroxyl radicals ·OH, superoxide anion-radicals O2·, and singlet molecular oxygen 1O2 were identified and determined by electron spin resonance spectroscopy. The quantity of generated radicals depend on initial oxygen concentration in irradiated solutions and on the energy of used neutron beam. The generation of radicals on the BNCT conditions could play an important role in therapeutical mechanism.


Neutron Beam Boron Neutron Capture Therapy Spin Trap Sodium Tetraborate Irradiate Solution 
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  1. 1.
    O.Strouf, P. Stopka: Coll. Czech. Chem. Comm. 60 (1995), 851.CrossRefGoogle Scholar
  2. 2.
    F. Flam: Science 265, (1994), 468.PubMedCrossRefGoogle Scholar
  3. 3.
    A.J. Carmichael, C.M. Arroyo, M.L. Moore: Radiat. Phys. Chem. 32. (1988) 227.Google Scholar
  4. 4.
    P. Stopka, O. Strouf: Coll. Czech. Chem. Comm. 56 (1991), 657.CrossRefGoogle Scholar
  5. 5.
    P. Stopka, O. Strouf, J. Burian: 6th Symp. on Neutron Capture Therapy, Oct.31-Nov.4, 1994, Kobe, Japan.Google Scholar
  6. 6.
    K. Makino, T. Hagiwara, and A. Murakami: Radiat. Phys. Chem. 37, (1991), 657.Google Scholar
  7. 7.
    A.N. Ledenev, A.A. Konstantinov, E. Popova, E.K. Ruuge: Biochem. Intern. 13, (1986) 391.Google Scholar
  8. 8.
    A.N. Ledenev, A.A. Konstantinov, E. Popova, E.K. Ruuge: Biol. Membrany (USSR) 3, (1986) 360.Google Scholar
  9. 9.
    Y. Lion, M. Delmelle, A. van de Vorst: Nature, 263, (1976), 442.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Pavel Stopka
    • 1
  • Jiří Burian
    • 2
  • Oldřich Štrouf
    • 1
  1. 1.Institute of Inorganic ChemistryAcademy of Sciences of Czech RepublicPraha 6Czech Republic
  2. 2.Nuclear Research InstituteŘežCzech Republic

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