Acute Toxicity of Elaidyl-1,2,-Carborane Carboxylate (ECC) in Rats

  • Merja Kallio
  • James Callaway
  • Elise Saario
  • Stephen Kahl


An effective boronation of low density lipoprotein (LDL), a potential boron carrier for BNCT, has been achieved with the elaidyl ester of 1,2,-carborane carboxylate (ECC)1,2. It is likely that in the body ECC will be cleaved into the carborane moiety and elaidyl alcohol. The elaidyl alcohol part will be changed back to elaidic acid, the trans form of oleic acid, and handled like trans fatty acids in general. The other part of ECC, 1,2-closo carborane, is a stable ortho carborane (OC)3 as the carboxylic acid. OC is quite nontoxic, peroral LD50 for mice is 9g/kg4. The toxicity of ECC is not known.


Trans Fatty Acid Injection Well Boron Concentration Elaidic Acid National Engineer Laboratory 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Merja Kallio
    • 1
  • James Callaway
    • 2
  • Elise Saario
    • 3
  • Stephen Kahl
    • 4
  1. 1.Department of NeurologyUniversity of HelsinkiHelsinkiFinland
  2. 2.MAP Medical Technologies Ltd.TikkakoskiFinland
  3. 3.Department of Pathological Anatomy College of Veterinary MedicineHelsinkiFinland
  4. 4.Department of Pharmaceutical ChemistryUniversity of CaliforniaSan FranciscoUSA

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