Toxicology and Pharmacokinetics of BOPP in a Canine Model

  • Stephen B. Kahl
  • Jay Tibbitts
  • John Fike

Abstract

The development of new tumor-selective boron compounds for the treatment of glioblastoma multiforme, melanoma and other malignancies only begins with the synthesis of new compounds. Compounds that show initial promise as a result of cell culture and small animal studies face the further requirement that they exhibit acceptable levels of toxicity in larger animal models. Furthermore the pharmacokinetic behavior of such compounds as determined in small animals must be re-examined at the level of larger mammals in order to more closely approximate their expected behavior in human Phase 1 biodistribution trials.

Keywords

Cephalic Vein Enterohepatic Recirculation Cerebral Glioma Segmented Neutrophil Intact Blood Brain Barrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    J.S. Hill, S.B. Kahl, A.H. Kaye, S.S. Stylli, M.S. Koo, M.F. Gonzales, N.J. Vardaxis and C.l. Johnson, Selective tumor uptake of a boronated porphyrinin animal model of cerebral glioma, Proc. Natl. Acad. Sci. USA 89: 1785–1789 1992.PubMedCrossRefGoogle Scholar
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    C.P. Ceberg, A. Brun, S.B. Kahl, M.S. Koo, B.R.R. Persson and L.G. Salford, A comparative study on the Pharmacokinetics and biodistribution of boronated porphyrin (BOPP) and sulthydryl boron hydride (BSH) in the RG-2 rat glioma model, J. Ncurosurg. (in press) 1995.Google Scholar
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    L.G. Salford, personal communication.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Stephen B. Kahl
    • 1
  • Jay Tibbitts
    • 1
  • John Fike
    • 1
  1. 1.Department of Pharmaceutical Chemistry Brain Tumor Research CenterUniversity of CaliforniaSan FranciscoUSA

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