Abstract
In this paper we confirm the retention of the physical characteristics and specific binding properties of low density lipoprotein (LDL) after extraction and reconstitution with a carborane compound. We also show that tumour uptake in vivo can be enhanced by downregulation of the LDL receptors in the liver and the adrenals, such that effective neutron capture therapy would be achievable with boronated LDL.
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Y.K. Ho, R.G.Smith, M.S. Brown, and J.L. Goldstein, Low density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood, 52: 1099–1104, 1978.
R.A. Firestone, Low density lipoprotein as a vehicle for targeting antitumor compounds to cancer cells, Bioconjugate Chem., 5: 105–113, 1994.
S.B. Kahl and J.L Callaway, New tumour localizer: advances in the use of low density lipoproteins, Strahlenther. Onkol., 165: 137–140, 1989.
B.H. Laster, S.B. Kahl, E.A. Popenoe, D.W. Pate, and R.G. Fairchild, Biological efficacy of boronated low density lipoprotein for boron neutron capture therapy as measured in cell culture, Cancer Res., 51: 4588–4593, 1991.
S.B. Kahl, L.A. Wainschel, D.W. Pate, J.C. Callaway, and J. Hiltunen, In vitro and in vivo studies with boronated low density lipoproteins for neutron capture, in: “Clinic BNCT Workshop,” liro Autrinen and Merja Kallio. eds., Helsinki, 1993, pp. 105–109.
R.J. Havel, H.A. Eder, and J.H. Bragdon, The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum., J. Clin. Invest., 34: 1345–1353, 1955.
M. Masquelier, S. Vitols, and C. Peterson, Low-density lipoprotein as a carrier ofantitumoral drugs: In vivo fate of drug-human low-density lipoprotein complexes in mice, Cancer Res., 46: 3842–3847, 1986.
M.D. Smith, Y. Setiawan, and D.E. Moore, Optimisation of drug anchor for ortho-carborane in reconstitution of low density lipoproteins. (These proceedings)
Y. Setiawan, T. Rise, and D.E. Moore, Fourier transform infrared (FTIR) spectrometry for the assay of polyhedral boron compounds in plasma and pharmaceutical formulations, Pharmaceutical Res., 1 1:723727, 1994.
M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding, Anal. Biochem., 72: 248–254, 1976.
S.S. Hynds, J. Welsh, J.M. Stewardt, A. Jack, M. Soukop, C.S. McArdle, K.C. Calman, C.J. Packard, and J. Shepherd, Low density lipoprotein metabolism in mice with soft tissue tumours. Biochimica ci Biophysica Acta, 795: 589–595, 1984.
S.R. Tamat, D.E. Moore, and B.J. Allen, Assay of boron in biological tissues by inductively coupled plasma atomic emission spectrometry, Anal. Chem., 59: 2161 2164, 1987.
B.J. Allen, S. Corderoy-Buck, J.L. Mallesch, K. Crotty, and D.E. Moore, Local control of subcutaneous murine melanoma xenografts in nude mice by neutron capture therapy. Melanoma Res., 2: 253–262, 1992.
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© 1996 Springer Science+Business Media New York
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Setiawan, Y., Smith, M.D., Moore, D.E., Allen, B.J. (1996). Pharmacokinetics and Effects of Neutron Capture on Melanoma Xenografts after Administration of Boronated Low Density Lipoprotein. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_85
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DOI: https://doi.org/10.1007/978-1-4757-9567-7_85
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