Evaluation of Response to Thermal Neutron Irradiation in Quiescent Cell Populations Within Murine Solid Tumors Using Micronucleus Assay
Boron neutron capture therapy has a potential to become the ideal cancer therapy, which selectively and maximally damages malignant cells with sparing normal tissue. This modality selectively concentrates a boron compound in malignant cells, and then activates this compound with slow thermal neutrons resulting in a lethal event within the cancer cell1,2. On the other hand, it is well known that many tumor cells are not proliferating (quiescent) in situ, but are still chronogenic. To improve treatment against cancer, it is also necessary to determine the response of quiescent tumor cells to the treatment.
KeywordsThermal Neutron Quiescent Cell Boron Neutron Capture Therapy Relative Biological Effectiveness Binucleate Cell
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