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Effect of Intratumoral Injection of 10B-Immunoliposome on BNCT for Growth Inhibition of Human Pancreatic Cancer Grafts in Nude Mice

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Book cover Cancer Neutron Capture Therapy

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Abstract

Cytotoxic effect of boron neutron capture therapy (BNCT) is due to the nuclear reaction between 10B and thermal neutrons. This nuclear reactions as followed

$${}^{10}B + {}^1n \to {}^4He + {}^7Li + 2.4MeV$$

The heavy charged particles from the 10B (n, α) 7Li reaction have a range of approximately 10 µm in tissue and are known to have a high relative biological effectiveness1). Therefore, it is theoretically possible to kill the tumor cells without affecting the adjacent normal cells, if effi-cient 10B atoms could be selectively accumulated in the tumor cells. BNCT has been applied clinically for treatment of malignant brain tumors2) or malignant melanoma3).

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References

  1. I. Kruger, P. G. Some biological effects of nuclear disintegration products on neoplastic tissue. Proc. Natl. Acad. Sci. USA., 26: 181–192, 1940.

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  3. . Mishima, Y., Ichihashi, M., Tsuji, M., Hatta, S., Ueda, M., Honda, C., et. al. Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet, 2: 388–389, 1989.

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Authors and Affiliations

  1. Department of Clinical Oncology Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku Tokyo 108, Japan

    Hironobu Yanagië, Yuzo Fujii, Yoshiyuki Saegusa & Masazumi Eriguchi

  2. Laboratory for Culture Collection Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku Tokyo 108, Japan

    Toshio Tomita

  3. Institute of Atomic Energy, Rikkyo University, 2-5-1 Nagasaka, Yokosuka, Kanagawa 240-01, Japan

    Hisao Kobayashi

  4. Research Reactor Institute, Kyoto University, Kumatori, Osaka 590-04, Japan

    Tooru Kobayashi, Keiji Kanda & Kouji Ono

Authors
  1. Hironobu Yanagië
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  2. Toshio Tomita
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  3. Hisao Kobayashi
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  4. Yuzo Fujii
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  5. Yoshiyuki Saegusa
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  6. Masazumi Eriguchi
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  7. Tooru Kobayashi
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  8. Keiji Kanda
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  9. Kouji Ono
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Editor information

Editors and Affiliations

  1. Mishima Institute for Dermatological Research, Kobe, Japan

    Yutaka Mishima (President) (President)

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© 1996 Springer Science+Business Media New York

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Yanagië, H. et al. (1996). Effect of Intratumoral Injection of 10B-Immunoliposome on BNCT for Growth Inhibition of Human Pancreatic Cancer Grafts in Nude Mice. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_8

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  • DOI: https://doi.org/10.1007/978-1-4757-9567-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9569-1

  • Online ISBN: 978-1-4757-9567-7

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