A Microdosimetry Model for In Vitro Boron Neutron Capture Irradiation Experiments Using d(14)+Be-Neutrons

  • F. Pöller
  • W. Sauerwein


It was shown that radiation effects in tumor cells treated with fast neutrons may be increased by neutron capture reactions 10B(n, α)7Li. Monte Carlo calculations of the energy depositions of short range particles with high LET coming from 10B disintegrations were performed and compared to the observed biological effects. The simulation allows us to study the influence of the localization of 10B localized inside the cell.

Calculations for a human melanoma cell population treated as monolayer in the presence or absence of boron with d(14)+Be-neutrons will be demonstrated. Two different 10B-enriched boron compounds were investigated in this study: boric acid (H3 10BO3) and p-dihydroxyboryl phenylalanine (BPA). The computer simulations indicate that BPA yield a higher potential effectiveness for inactivation of melanoma cells than boric acid.


Boric Acid Fast Neutron Neutron Capture Boron Neutron Capture Therapy Boron Compound 
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  1. L D. Gabel, Present status and perspectives of boron neutron capture therapy, Radiother. Oncol. 30: 199–205. 1994.PubMedCrossRefGoogle Scholar
  2. 2.
    H. Hatanaka, Boron-neutron capture therapy for tumors, in “ Glioma” A.B.M.F. Karim and E.R. Laws, ed., Springer Verlag, Berlin, 1991, pp. 233–249CrossRefGoogle Scholar
  3. 3.
    F. Pöller, W. Sauerwein and J. Rassow, Monte Carlo calculation of dose enhancement by neutron capture of 10B in fast neutron therapy, Phys. Med. Biol. 38: 397–410, 1993.PubMedCrossRefGoogle Scholar
  4. 4.
    D. Gabel, S. Foster and R. G. Fairchild, The Monte Carlo simulation of the biological effect of the 10B(n,a.)7Li reaction in cells and tissue and its implication for boron neutron capture therapy, Radiat. Res. 111: 14–25, 1987.PubMedCrossRefGoogle Scholar
  5. 5.
    D. E. Charlton, Energy deposition in small ellipsoidal volumes by high-LET particles: application to thermal neutron dosimetry, Int. J. Radiat. Biol. 59: 827–842, 1991.PubMedCrossRefGoogle Scholar
  6. 6.
    W. Sauerwein, W. Ziegler, H. Szypniewski and C. Streffer, Boron neutron capture therapy using fast neutrons: effects in two tumor cell lines, Strahlenth. Onkol. 166: 26–29, 1990.Google Scholar
  7. 7.
    J. F. Ziegler, J. P. Biersack and U. Littmark,“The stopping and range of ions in solids,” Pergamon Press, New York, 1985.Google Scholar
  8. 8.
    R. Verrijk, R. Huiskamp, A. C. Begg, F. J. Wheeler and P.R.D. Watkins, A comprehensive PC- based computer model for microdosimetry of BNCT, Int. J. Radiat. Biol. 65: 241–253, 1994.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • F. Pöller
    • 1
  • W. Sauerwein
    • 2
  1. 1.Department of Medical Radiation PhysicsUniversity of EssenEssenFederal Republic of Germany
  2. 2.Department of Radiation OncologyUniversity of EssenEssenFederal Republic of Germany

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