Abstract
The therapeutic effect of boron neutron capture therapy depends on the microscopic distribution of the boron atoms. A given macroscopic boron distribution can yield completely different therapeutic effects for different distributions of the boron atoms on a microscopic scale. In this work, a stochastic model for the subcellular dosimetry has been developed to calculate the effect of BNCT in tumour cells as well as in capillaries for different capture reactions and for proton recoil. The microdosimetry model calculates the dose distribution on a cellular scale, the probability functions of energy depositions in the cell nucleus (hit size curve) and the cell survival fractions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
P.R. Gavin, R. Huiskamp, F.J. Wheeler and M.L. Griebenow, Computer modelling the boron compound factor in normal brain tissue, in: “Advances in Neutron Capture Therapy”, A.H. Soloway et al. ed., Plenum Press, New York, 1993, pp 591–595.
C. Charlton and B.J. Allen, Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy, Int. J. Radiat. Biol., 64: 739–747, 1993.
F. Stecher-Rasmussen, G. Constantine, W. Freudenreich, H.J.M. de Haas, R.L. Moss, A. Paardekoper, K. Ravensberg, H. Verhagen, W. Voorbraak and P.R.D. Watkins, From filter installation to beam characterization, in: “Boron Neutron Capture Therapy”, D. Gabel and R. Moss ed., Plenum Press, New York, 1992, pp 59–77.
F.J. Wheeler, private communication.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Vroegindeweij, C., Wheeler, F.J., Stecher-Rasmussen, F., Huiskamp, R., Gabel, D. (1996). A Microdosimetry Model for BNCT Analysis. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_69
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9567-7_69
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9569-1
Online ISBN: 978-1-4757-9567-7
eBook Packages: Springer Book Archive