Dose Sparing of Capillary Endothelial Cells for BSH and BPA

A Model for Capillary Truncation
  • D. E. Charlton
  • B. J. Allen


In Boron Neutron Capture Therapy (BNCT), boron is selectively taken up by cancer cells and activated in situ by a beam of neutrons. However, boron is also taken up by normal cells in some fixed relationship with boron concentration of blood. The kinetics of boron in tissues may then be related to blood boron kinetics. Normal tissue tolerance dose should not be exceeded in BNCT, so it is important to know the boron concentration in blood and normal tissues in the irradiation volume. Further, it is important to be aware of the dose sparing properties of a given boron compound with respect to the microscopic dose distribution. The short range of the boron neutron capture reaction products and the relatively low rate of capture events is such that microscopic events are described by Poisson statistics and determined by cellular geometry and the achievement or otherwise of dose equilibrium.


Neutron Capture Boron Concentration Capillary Endothelial Cell Boron Neutron Capture Therapy Neutron Fluence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D.E. Charlton and B.J. Allen, Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy, Int J Radiai Biol 64: 739–747, 1993.CrossRefGoogle Scholar
  2. 2.
    B.J. Allen, Maximum therapeutic depth in thermal neutron capture therapy, Strahlcnther Onkol 169: 34–41, 1993.Google Scholar
  3. 3.
    T. Nguyen, B.A. Teicher, M. Miura, S.B. Kahl and G.L. Brownell, Intracellular distributions of various boron compounds in rat 9L gliosarcoma cells, in: “Progress in Neutron Capture Therapy,” B J Allen et al, ed., Plenum Press, NY, 1992, pp. 381–385.CrossRefGoogle Scholar
  4. 4.
    W.S. Snyder, M.J. Cook, E.S. Nasset, L.R. Karhausen, G.P. Howells and I.H. Lipton, Report of the task group on reference man, ICRP 23 Pergamon Press 1975.Google Scholar
  5. 5.
    B.J. Allen, M. Bilek and D.E. Charlton, Monte Carlo calculation of microdosimetry in nitrogen and boron neutron capture reactions, in: “Advances in Neutron Capture Therapy,” A H Soloway et al, ed., Plenum Press, New York, 1993, pp. 221–224.CrossRefGoogle Scholar
  6. 6.
    D. Gabel, S. Foster and R.G. Fairchild, The Monte Carlo simulation of the biological effect of the 10B(n,a)7Li reaction in cells and tissue and its implication for BNCT, Radial Res. 111: 14–25, 1987.CrossRefGoogle Scholar
  7. 7.
    P.R. Gavin, F.J. Wheeler, R. Huiskamp, C.E. de Haan and K.H.I. Philipp, Large animal normal tissue tolerance with boron neutron capture: comparison with empirical results with a microdosimetric model, MIT Workshop on Macro and Microdosimetry, Cambridge, USA, 1991.Google Scholar
  8. 8.
    R. Huiskamp, P.R. Gavin, J.A. Coderre and F.J. Wheeler, Brain tolerance in dogs to BNCT with borocaptate sodium (BSH) and boronphenylalanine (BPA), these proceedings.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • D. E. Charlton
    • 1
  • B. J. Allen
    • 2
  1. 1.Concordia UniversityMontrealCanada
  2. 2.St George Cancer Care CentreKogarahAustralia

Personalised recommendations