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Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance

Application to Mouse Melanoma and Prospects for Humans

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Abstract

One of the major problems associated with the successful clinical implementation of boron neutron capture therapy (BNCT), is the ability to determine boron-10 concentrations in the tumor and the surrounding tissue in the treated patient, during and following the infusion of the BNCT agents. In this chapter we describe the results of pilot experiments conducted in an animal model, aimed at evaluating the potential of nuclear magnetic resonance (NMR) to perform this task, and extrapolate from these results to the expected performance in human patients.

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References

  1. D.D. Stark and W.G. Bradley, eds., “Magnetic Resonance Imaging”, Mosby, St. Louis, 1992 Vol. 1.

    Google Scholar 

  2. G.W. Kabalka, M. Davis, and P. Bendel, Boron-11 MRI and MRS of intact animals infused with a boron neutron capture agent, Magn. Reson. Med. 8: 231–237, 1988.

    Article  CAS  Google Scholar 

  3. P. Bendel, M. Davis, E. Berman, and G.W. Kabalka, A method for imaging nuclei with short T, relaxation and its application to boron-11 MR imaging of a BNCT agent in an intact rat, J. Magn. Reson. 88: 369–375, 1990.

    CAS  Google Scholar 

  4. G.W. Kabalka, G-Q. Cheng, P. Bendel, P.L. Micca, and D.N. Slatkin, In-vivo boron-11 MRI and MRS using (B24H22S2)4- in the rat, Magn. Reson. Imaging 9: 969–973, 1991.

    Article  CAS  Google Scholar 

  5. K. M. Bradshaw, T.L. Richards, and S.L. Kraft, In-vivo pharmacokinetic evaluation of boron compounds using magnetic resonance spectroscopy and imaging, in: “Progress in Neutron Capture Therapy for Cancer,” B.J. Allen, D.E. Moore, and S.V. Harrington, eds., Plenum Press, New-York, 1992, pp. 325–330.

    Chapter  Google Scholar 

  6. G.H. Glover, J.M. Pauly, and K.M. Bradshaw, Boron-11 imaging with a three-dimensional reconstruction method, J. Magn. Reson. Imaging 2: 47–52, 1992.

    Article  PubMed  CAS  Google Scholar 

  7. F. De Luca, R. Campanella, A. Bifone, and B. Maraviglia, Buron-10 double resonance spatial NMR detection, Chem. Phys. Lett. 186: 303–306, 1991.

    Article  Google Scholar 

  8. P. Bendel, J. Zilberstein, and Y. Salomon, In-vivo detection of a boron neutron capture agent in melanoma by proton-observed ‘H–10B double resonance, Magn. Reson. Med. 32: 170–174, 1994.

    Article  CAS  Google Scholar 

  9. J.E. Gerst, J. Sole, J.P. Mather, and Y. Salomon, Regulation of adenylate cyclase by 13-melanotropin in the M2R melanoma cell line, Mol. Cell Endocrinol. 46: 137–147, 1986.

    Article  CAS  Google Scholar 

  10. E.I. Tolpin, G.R. Wellum, and S.A. Berley, Synthesis and chemistry of mercapto/undecahydro-closo-dodecaborate(2-), lnorg. Chem. 17: 2867–2873, 1978.

    CAS  Google Scholar 

  11. M. Suzuki, and R. Kubo, Theoretical calculation ofN.M.R. spectral line shapes, Molec. Phys. 7: 201–209, 1964.

    CAS  Google Scholar 

  12. A. Abragam, “Principles of Nuclear Magnetism,” Clarendon Press, Oxford, 1989.

    Google Scholar 

  13. D.I. Hoult, and P.C. Lauterbur, The sensitivity of the zeugmatographic experiment involving human samples, J. Magn. Reson. 34: 425–433, 1979.

    CAS  Google Scholar 

  14. C-N. Chen, and D.I. Hoult, `Biomedical Magnetic Resonance Technology“, Adam Hilger, Bristol, 1989 pp. 130.

    Google Scholar 

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© 1996 Springer Science+Business Media New York

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Bendel, P., Zilberstein, J., Salomon, Y., Kabalka, G.W. (1996). Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_34

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  • DOI: https://doi.org/10.1007/978-1-4757-9567-7_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9569-1

  • Online ISBN: 978-1-4757-9567-7

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