Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance

Application to Mouse Melanoma and Prospects for Humans
  • Peter Bendel
  • Judith Zilberstein
  • Yoram Salomon
  • George W. Kabalka


One of the major problems associated with the successful clinical implementation of boron neutron capture therapy (BNCT), is the ability to determine boron-10 concentrations in the tumor and the surrounding tissue in the treated patient, during and following the infusion of the BNCT agents. In this chapter we describe the results of pilot experiments conducted in an animal model, aimed at evaluating the potential of nuclear magnetic resonance (NMR) to perform this task, and extrapolate from these results to the expected performance in human patients.


Nuclear Magnetic Resonance Boron Neutron Capture Therapy Indirect Detection Spin Quantum Number Nuclear Magnetic Resonance Detection 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Peter Bendel
    • 1
    • 2
  • Judith Zilberstein
    • 1
    • 2
  • Yoram Salomon
    • 1
    • 2
  • George W. Kabalka
    • 1
    • 2
  1. 1.Department of Chemical Physics (P.B.) and Hormone Research (J.Z., Y.S.)The Weizmann Institute of ScienceRehovotIsrael
  2. 2.Department of ChemistryUniversity of TennesseeKnoxvilleUSA

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