Analysis of Boron in LDL-Matrix

  • Sauli Savolainen
  • Jyrki Räisänen
  • Juha Laakso
  • Inkeri Ruokonen
  • Riitta Zilliacus
  • Jari Likonen
  • Usama Abo Ramadan
  • Veli Eteläniemi
  • James Callaway
  • Merja Kallio

Abstract

New boronated molecules that accumulate in tumor cells through various mechanisms have been introduced in recent years. The Finnish BNCT research group is studying boronated LDL as a potential 10B carrier1,2. Boron concentrations have been determined by charged particle bombardment and by different forms of inductively-coupled plasma analysis3,4,5. Also, the use of thermal neutrons in prompt-γ analysis of 10B has been described recently6,7. In this study four boron analysis methods have been tested: proton induced gamma emission analysis, inductively coupled atomic emission spectrometry and mass spectrometry, and secondary ion mass spectrometry.

Keywords

Boron Concentration External Proton Beam Charged Particle Bombardment Absolute Boron Concentration Boron Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S.B. Kahl and J.C. Callaway, New tumor localizers: advances in the use of low density lipoproteins (LDL), Strahlenther:Onkol. 165: 137–139, 1989.PubMedGoogle Scholar
  2. 2.
    J. Leppälä, M. Kallio, T. Nikula, P. Nikkinen, K. Liewendahl, J. Jääskeläinen, S. Savolainen, H. Gylling, J. Hiltunen, J. Callaway, S. Kahl, and M. Färkkilä, Accumulation of 99mTc-LDL in human malignant glioma. Br. J. Cancer 71: 383–387, 1995.PubMedCrossRefGoogle Scholar
  3. 3.
    N. Moncoffre, Analysis of boron by charged particle bombardment. Nucl. Inst. Meth. Phys. Res. B66: 126–138, 1992.CrossRefGoogle Scholar
  4. 4.
    B. Bauer, Analyses of boron in biological samples, in: “INEL BNCT Research Program Annual Report 1992”, J.R. Venhuizen, ed., Idaho National Engineering Laboratory, Idaho Falls, Idaho, 1993, pp. 78–117.Google Scholar
  5. 5.
    A.H. Soloway, R.F. Barth and D.E. Carpenter, eds., “Advances in Neutron Capture Therapy. Plenum Press, New York, 1993, pp. 403–443.Google Scholar
  6. 6.
    T. Matsumoto, M. Aoki and O. Aizawa, Phantom experiment and calculation for in vivo 10boron analysis by prompt gamma ray spectroscopy. Phys. Med. Biol. 36: 329–338, 1991.PubMedCrossRefGoogle Scholar
  7. 7.
    M.W. Konijnenberg, C.P.J. Raaijmakers, G. Constantine, L.G.H. Dewit, B.J. Mijnheer, R.L. Moss, and F. Stecher-Rasumussen, Prompt gamma-ray analysis to determine 10B concentrations, in: “Advances in Neutron Capture Therapy” A.H. Soloway et al. eds., Plenum Press, New York, 1993: 419–422.CrossRefGoogle Scholar
  8. 8.
    J. Räisänen, Elemental analysis with external beam methods. Nucl. Inst. Meth. Phys. Res. B40/41:638642, 1989.Google Scholar
  9. 9.
    J. Räisänen, An external proton beam for PIGE analysis. Nucl. Inst. Meth. Phys. Res. B3: 220–223, 1984.CrossRefGoogle Scholar
  10. 10.
    S. Savolainen, J. Räisänen, V. Eteläniemi, U. Abo Ramadan, and M. Kallio, Analysis of Boron-10 by PIGE with Factor Analytical y-ray Peak Identification Appl. Radial. ‘sot. (in press). Google Scholar
  11. 11.
    J. Folch, M. Lees and G.H.S. Stanley. J. Biol. Chem., 226, 497–509, 1975.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Sauli Savolainen
    • 1
  • Jyrki Räisänen
    • 1
  • Juha Laakso
    • 2
  • Inkeri Ruokonen
    • 2
  • Riitta Zilliacus
    • 3
  • Jari Likonen
    • 3
  • Usama Abo Ramadan
    • 1
  • Veli Eteläniemi
    • 1
  • James Callaway
    • 4
  • Merja Kallio
    • 5
  1. 1.Department of PhysicsHelsinki UniversityFinland
  2. 2.Mineral Laboratory Mila Ltd.Finland
  3. 3.Chemical TechnologyTechnical Research Centre of FinlandFinland
  4. 4.MAP Medical Technologies Inc.Finland
  5. 5.Department of NeurologyHelsinki University Central HospitalFinland

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