Skip to main content

Analysis of Boron in LDL-Matrix

  • Chapter
Cancer Neutron Capture Therapy

Abstract

New boronated molecules that accumulate in tumor cells through various mechanisms have been introduced in recent years. The Finnish BNCT research group is studying boronated LDL as a potential 10B carrier1,2. Boron concentrations have been determined by charged particle bombardment and by different forms of inductively-coupled plasma analysis3,4,5. Also, the use of thermal neutrons in prompt-γ analysis of 10B has been described recently6,7. In this study four boron analysis methods have been tested: proton induced gamma emission analysis, inductively coupled atomic emission spectrometry and mass spectrometry, and secondary ion mass spectrometry.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S.B. Kahl and J.C. Callaway, New tumor localizers: advances in the use of low density lipoproteins (LDL), Strahlenther:Onkol. 165: 137–139, 1989.

    PubMed  CAS  Google Scholar 

  2. J. Leppälä, M. Kallio, T. Nikula, P. Nikkinen, K. Liewendahl, J. Jääskeläinen, S. Savolainen, H. Gylling, J. Hiltunen, J. Callaway, S. Kahl, and M. Färkkilä, Accumulation of 99mTc-LDL in human malignant glioma. Br. J. Cancer 71: 383–387, 1995.

    Article  PubMed  Google Scholar 

  3. N. Moncoffre, Analysis of boron by charged particle bombardment. Nucl. Inst. Meth. Phys. Res. B66: 126–138, 1992.

    Article  Google Scholar 

  4. B. Bauer, Analyses of boron in biological samples, in: “INEL BNCT Research Program Annual Report 1992”, J.R. Venhuizen, ed., Idaho National Engineering Laboratory, Idaho Falls, Idaho, 1993, pp. 78–117.

    Google Scholar 

  5. A.H. Soloway, R.F. Barth and D.E. Carpenter, eds., “Advances in Neutron Capture Therapy. Plenum Press, New York, 1993, pp. 403–443.

    Google Scholar 

  6. T. Matsumoto, M. Aoki and O. Aizawa, Phantom experiment and calculation for in vivo 10boron analysis by prompt gamma ray spectroscopy. Phys. Med. Biol. 36: 329–338, 1991.

    Article  PubMed  CAS  Google Scholar 

  7. M.W. Konijnenberg, C.P.J. Raaijmakers, G. Constantine, L.G.H. Dewit, B.J. Mijnheer, R.L. Moss, and F. Stecher-Rasumussen, Prompt gamma-ray analysis to determine 10B concentrations, in: “Advances in Neutron Capture Therapy” A.H. Soloway et al. eds., Plenum Press, New York, 1993: 419–422.

    Chapter  Google Scholar 

  8. J. Räisänen, Elemental analysis with external beam methods. Nucl. Inst. Meth. Phys. Res. B40/41:638642, 1989.

    Google Scholar 

  9. J. Räisänen, An external proton beam for PIGE analysis. Nucl. Inst. Meth. Phys. Res. B3: 220–223, 1984.

    Article  Google Scholar 

  10. S. Savolainen, J. Räisänen, V. Eteläniemi, U. Abo Ramadan, and M. Kallio, Analysis of Boron-10 by PIGE with Factor Analytical y-ray Peak Identification Appl. Radial. ‘sot. (in press).

    Google Scholar 

  11. J. Folch, M. Lees and G.H.S. Stanley. J. Biol. Chem., 226, 497–509, 1975.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Savolainen, S. et al. (1996). Analysis of Boron in LDL-Matrix. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9567-7_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9569-1

  • Online ISBN: 978-1-4757-9567-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics