Netropsin and Distamycin Analogues Bearing Ortho-Carborane

  • Yoshinori Yamamoto
  • Jianping Cai
  • Hiroyuki Nakamura
  • Naoki Sadayori
  • Hisao Nemoto


The application of the cytotoxic 10B neutron-capture reaction [10B(n,α)7Li] to the treatment of human tumors has received much attention in recent years. The interaction of boron-10 isotope and thermal neutron produces an α-particle and recoils a lithium-7 ion bearing approximately 2,4 MeV (Eq. 1).


Neutron Capture Boron Atom Boronic Acid Boron Neutron Capture Therapy Purine Nucleoside 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yoshinori Yamamoto
    • 1
  • Jianping Cai
    • 1
  • Hiroyuki Nakamura
    • 1
  • Naoki Sadayori
    • 1
  • Hisao Nemoto
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceTohoku UniversitySendaiJapan
  2. 2.Department of Applied Molecular ScienceInstitute for Molecular ScienceOkazaki 444Japan

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