Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety Via Palladium Catalyzed Reaction under Essentially Neutral Conditions

  • Hisao Nemoto
  • Jianping Cai
  • Yoshinori Yamamoto


Although the icosahedral boron cluster, dodecaboranethiol (1), has been used clinically1 as a boron carrier for boron neutron capture therapy (BNCT), we still need to enhance the efficiency and selectivity of boron uptake by cancer cells. Therefore, a number of synthetic studies of boron carriers2~7 containing the similar cluster, o-carborane (2) have been recently reported (Figure 1).


Boron Neutron Capture Therapy Boron Uptake Methyl Chloroformate Allyl Carbonate Cascade Type 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hisao Nemoto
    • 1
  • Jianping Cai
    • 1
  • Yoshinori Yamamoto
    • 2
  1. 1.Department of Applied Molecular ScienceInstitute for Molecular Science, Okazaki National Research InstitutesOkazaki, Aichi 444Japan
  2. 2.Department of Chemistry, Faculty of ScienceTohoku UniversityJapan

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