Synthesis of Boronated Uridine Derivatives for Boron Neutron Capture Therapy

  • G. W. Kabalka
  • N. Kesavulu Reddy
  • C. Narayana


The effectiveness of boron neutron capture therapy would be maximized if the capture reaction occurred in the cell nucleus.1 Thus boronated nucleic acid precursors may be ideal agents for achieving high selective boron concentrations in the nucleus of tumor cells since they should be readily taken up by rapidly proliferating malignant cells and incorporated into cellular DNA or RNA.


Boron Neutron Capture Therapy Lithium Iodide Tetrabutylammonium Fluoride Retrosynthetic Analysis Nucleic Acid Precursor 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. W. Kabalka
    • 1
  • N. Kesavulu Reddy
    • 1
  • C. Narayana
    • 1
  1. 1.Departments of Chemistry and RadiologyUniversity of TennesseeKnoxvilleUSA

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