Abstract
The effectiveness of boron neutron capture therapy would be maximized if the capture reaction occurred in the cell nucleus.1 Thus boronated nucleic acid precursors may be ideal agents for achieving high selective boron concentrations in the nucleus of tumor cells since they should be readily taken up by rapidly proliferating malignant cells and incorporated into cellular DNA or RNA.
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Kabalka, G.W., Reddy, N.K., Narayana, C. (1996). Synthesis of Boronated Uridine Derivatives for Boron Neutron Capture Therapy. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_21
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DOI: https://doi.org/10.1007/978-1-4757-9567-7_21
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