Recent Results with Liposomes as Boron Delivery Vehicles for Boron Neutron Capture Therapy

  • M. Frederick Hawthorne
  • Debra A. Feakes
  • Kenneth Shelly

Abstract

The slow evolution of effective drug-targeting methodologies for the selective delivery of boron to cancer cells persists as an important obstacle to the development of boron neutron capture therapy.1 Simple boron compounds offer the convenience of availability and ease of synthesis but often exhibit low selectivity and require large injected doses in order to produce the required boron concentrations in tumor. The development of new boron compounds with natural tumor selectivity is problematic. The conjugation of boron-rich moieties to existing tumor-selective substrates often leads to problems with loss of tumor specificity, water solubility, and toxicity.

Keywords

Boron Neutron Capture Therapy Boron Compound Aqueous Core Tumor Retention Liposomal Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. Frederick Hawthorne
    • 1
  • Debra A. Feakes
    • 2
    • 1
  • Kenneth Shelly
    • 1
  1. 1.Department of Chemistry and BiochemistryUniversity of California at Los AngelesLos AngelesUSA
  2. 2.Department of ChemistrySouthwest Texas State UniversitySan MarcosUSA

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