Abstract
The slow evolution of effective drug-targeting methodologies for the selective delivery of boron to cancer cells persists as an important obstacle to the development of boron neutron capture therapy.1 Simple boron compounds offer the convenience of availability and ease of synthesis but often exhibit low selectivity and require large injected doses in order to produce the required boron concentrations in tumor. The development of new boron compounds with natural tumor selectivity is problematic. The conjugation of boron-rich moieties to existing tumor-selective substrates often leads to problems with loss of tumor specificity, water solubility, and toxicity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. M.F. Hawthorne, The role of chemistry in the development of boron neutron capture therapy, Angew.. Chem. Int. Ed. Eng. 32: 950–984, 1993.
K. Shelly, M.F. Hawthorne, and P.G. Schmidt, Liposomal delivery of boron for BNCT, in: “Progress in Neutron Capture Therapy for Cancer;” B.J. Allen, et al., ed., Plenum Press, New York, 1992, pp. 259–264.
D.A. Feakes, K. Shelly, M.F. Hawthorne, P.G. Schmidt, C.A. Elstad, G.G. Meadows, and W.F. Bauer, Liposomal delivery of boron to tumors for boron neutron capture therapy, in: “Advances in Neutron Capture Therapy,” A.H. Soloway, et al., ed.. Plenum Press, New York, 1993, pp. 395–398.
M.F. Hawthorne and R.L. Pilling, Bis(triethylammonium) decahydrodecaborate(2-), Inorg.Srnth. 9: 16–19, 1967.
K. Shelly, C.B. Knobler, and M.F. Hawthorne, Synthesis of monosubstituted derivatives of clo.so-decahydrodecaborate(2-). X-ray crystal structures of [dosa-2-B 10 H 9 CO]’ and ldoso-2-Bi5H,NCO]2-, Inorg. Chem. 31: 2889–2892, 1992.
D.A. Johnson, D.D. Seimer, and W.F. Bauer, Determination of nanogram levels of boron in milligram-sized samples by inductively coupled plasma-atomic emission spectroscopy, Anal. (’him. Acta. 270: 223–230, 1992.
B.L. Chamberland and E.L. Muetterties, Chemistry of Boranes. XVIII. Oxidation of [B10H15]2- and its derivatives, lnorg. Chem. 3: 1450–1458, 1964.
M.F. Hawthorne, R.L. Pilling, and P.M. Garrett, A study of the reaction of hydroxide ion with B25H J. Am. Chem. Soc. 87: 4740–4746, 1965.
K. Shelly, D.A. Feakes, M.F. Hawthorne, P.G. Schmidt, T.A. Krisch, and W.F. Bauer, Model studies directed toward the neutron capture therapy of cancer: boron delivery to murine tumors with liposomes, Pro’ Natl. Acad. Sci. USA 89: 9039–9043, 1992.
D.A. Feakes, K. Shelly, C.B. Knobler, and M.F. Hawthorne, Na3[B,5Hi7NH3]: synthesis and liposomal delivery to murine tumors, Proc. Natl. Acad. Sci. USA 91: 3029–3033, 1994.
D.A. Feakes, K. Shelly, and M.F. Hawthorne, Selective boron delivery to murine tumors by lipophilic species incorporated in the membranes of unilamellar liposomes, Proc. Natl. Acad. Sci. USA,in press.
D. Lasic, Liposomes, Am. Sci. 80: 20–31, 1992.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hawthorne, M.F., Feakes, D.A., Shelly, K. (1996). Recent Results with Liposomes as Boron Delivery Vehicles for Boron Neutron Capture Therapy. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_2
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9567-7_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9569-1
Online ISBN: 978-1-4757-9567-7
eBook Packages: Springer Book Archive