Chemical Behavior of Boron-Containing Amino Acids for Neutron Capture Therapy in Aqueous Solutions

  • Mitsue Kobayashi
  • Yoshinori Kitaoka


Because of poor solubility of p-boronophenylalanine (BPA) in water, BPA-fructose complex has been used at clinical experiments of BNCT1. Complexation is a method of choice to improve the solubility of BPA2. Based on the electrophoretic behavior, we had reported that BPA formed negatively charged complexes with some carboxylic acids such as oxalic acid and citric acid3. Chemical states of BPA in aqueous oxalic acid and in aqueous fructose were investigated mainly by infrared (IR) spectroscopy. The chemical nature of dihydroxyboryl group of p-boronophenylserine (BPS) in the aqueous solutions was examined and compared with that of BPA.


Oxalic Acid Boron Atom Calcium Fluoride Paper Electrophoresis Thermal Neutron Capture 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mitsue Kobayashi
    • 1
  • Yoshinori Kitaoka
    • 1
  1. 1.Research Reactor InstituteKyoto UniversityOsaka 590-04Japan

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