Synthesis and Initial Biological Evaluation of Carborane-Containing Phenanthridinium Derivatives

  • Werner Tjarks
  • Jonas Malmquist
  • Lars Gedda
  • Stefan Sjöberg
  • Jörgen Carlsson

Abstract

The radiobiological effectiveness of the neutron capture reaction is 2–5 times greater when it occurs in the cell nucleus rather than in the cytoplasm.1 One class of compounds which may be suitable agents to achieve high and selective boron concentrations in tumor cell nuclei are boronated derivatives of nucleic acid building blocks.2 Another type of compounds may be boronated DNA intercalator. Only a few boron-containing DNA-ligands have been prepared so far.3–5

Keywords

Boron Neutron Capture Therapy Tumor Cell Nucleus Neutron Capture Reaction Conventional Fluorescence Microscope Phosphoryl Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Werner Tjarks
    • 1
  • Jonas Malmquist
    • 1
  • Lars Gedda
    • 2
  • Stefan Sjöberg
    • 1
  • Jörgen Carlsson
    • 2
  1. 1.Dept. of Organic ChemistryUppsala UniversityUppsalaSweden
  2. 2.Dept. of Radiation SciencesUppsala UniversityUppsalaSweden

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