Abstract
The radiobiological effectiveness of the neutron capture reaction is 2–5 times greater when it occurs in the cell nucleus rather than in the cytoplasm.1 One class of compounds which may be suitable agents to achieve high and selective boron concentrations in tumor cell nuclei are boronated derivatives of nucleic acid building blocks.2 Another type of compounds may be boronated DNA intercalator. Only a few boron-containing DNA-ligands have been prepared so far.3–5
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Tjarks, W., Malmquist, J., Gedda, L., Sjöberg, S., Carlsson, J. (1996). Synthesis and Initial Biological Evaluation of Carborane-Containing Phenanthridinium Derivatives. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_15
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DOI: https://doi.org/10.1007/978-1-4757-9567-7_15
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