Boron MRI in a Tumor Bearing Canine Model
Over the past several years, we have been involved in the development of a noninvasive magnetic resonance imaging (MRI) method for quantifying boron drug pharmacokinetics in tumor and other tissues of the canine head1–3. The underlying aims for this research are to provide a method to evaluate the suitability of boron compounds and to provide a potential drug prescreen as an aid to BNCT dosimetry calculations to be used in patient treatment planning.
KeywordsInductively Couple Plasma Atomic Emission Spectroscopy Inductively Couple Plasma Atomic Emission Spectroscopy Magnetic Resonance Imaging Technique Blood Brain Barrier Damage Proton Image
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- 2.K.M. Bradshaw, M.P. Schweizer, G.H. Glover and J.R. Hadley. Pharmacokinetics of borocaptate sodium in canine head determined by boron-11 magnetic resonance imaging and spectroscopy, in “Advances in Neutron Capture Therapy,” Soloway, A.H., Barth, R.F. and Carpenter, 1).1., eds., Plenum Press, New York, 1993, pp. 579–583CrossRefGoogle Scholar
- K.M. Bradshaw, M.P. Schweizer, G.H. Glover, et al.,BSH distributions in the canine head and a human patient using 11B MRI, Magn. Reson. Med. 1995.Google Scholar
- 4.S.L. Kraft, P.R. Gavin, C.E. DeHaan, C.W. Leathers, W.F. Bauer and R.V. Dorn. The biodistribution of boron in canine spontaneous intracranial tumors following borocaptate sodium infusion, in: “Progress in NCT for Cancer.,” Allen, B.J., Moore, D.E. and Harrington, B.V., eds., Plenum Press, New York, 1992, pp. 479–484Google Scholar
- 5.S.P. Hendee, K.M. Bradshaw, J.R. Hadley, P.-P.Z. Tang and M.P. Schweizer. In vivo NMR evaluation of the pharmacokinetics of boronated compounds in the rat model, in.. “Cancer Neutron Capture Therapy,” Mishima, Y., ed. Plenum Press, New York, 1995, (in this volume).Google Scholar
- 6.K.M. Bradshaw, J.R. Hadley, M.P. Schweizer, M.P. Heilbrun, W.L. Davis and G.H. Glover. First boron MRI of a human patient with a brain tumor, in:“Cancer Neutron Capture Therapy,” Mishima, Y., ed. Plenum Press, New York, 1995, (in this volume).Google Scholar
- 7.P.-P.Z. Tang, M.P. Schweizer, J.R. Hadley, S.P. Hendee, R.H. Tippets and K.M. Bradshaw. TI measurements to study the penetration of BNCT agents into canine tumors caused by blood brain barrier damage, in:“Cancer Neutron Capture Therapy,” Mishima, Y., ed. Plenum Press, New York, 1995, (in this volume).Google Scholar