Selective Detection of Brain Metastasis of Malignant Melanoma Using 18F-10B-L-Borono-Phenylalanine with Positron Emission Tomography

  • Kazumasa Ehara
  • Norihiko Tamaki
  • Yoshie Hara
  • Yoshio Imahori
  • Hitoshi Horii
  • Satoshi Ueda
  • Jun’ichi Hiratsuka
  • Yutaka Mishima

Abstract

Selective neutron capture therapy (NCT) using specific dopa analog,10B-p-boronophenylalanine (10B-L-BPA) for malignant melanoma of the skin was developed and achieved many cures by Mishima and his group1,2. We had developed 18F-10B-L-Boronophenylalanine which can not only provide selective detection and three dimensional imaging, but also 10B concentration dynamics clinically using positron emission tomography (PET)3,4,5. The purpose of this study is to explore NCT of melanoma brain metastasis using this compound.

Keywords

Positron Emission Tomography Brain Metastasis Positron Emission Tomography Study Boron Neutron Capture Therapy Perifocal Edema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kazumasa Ehara
    • 1
  • Norihiko Tamaki
    • 1
  • Yoshie Hara
    • 1
  • Yoshio Imahori
    • 2
    • 3
  • Hitoshi Horii
    • 3
  • Satoshi Ueda
    • 2
  • Jun’ichi Hiratsuka
    • 4
  • Yutaka Mishima
    • 5
  1. 1.Department of NeurosurgeryKobe UniversityJapan
  2. 2.Department of NeurosurgeryKyoto Prefectural University of MedicineJapan
  3. 3.Positron Emission CenterNishijin HospitalJapan
  4. 4.Department of RadiologyKawasaki Medical SchoolJapan
  5. 5.Mishima Institute for Dermatological ResearchJapan

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