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Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor

The First Clinical Trial Using10B-BPA

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Cancer Neutron Capture Therapy

Abstract

We have conjugated a positron tracer F-18 to [10B]boronophenylalanine (10B-BPA) to synthesize [18F]fluoroboronophenylalanine (18F-10B-DL-BPA or 18F-10B-L-BPA), and analyzed 1013-BPA metabolism on 27 cases of the various brain tumors by positron emission tomography (PET). These PET data revealed that 18F-10B-BPA using the DL-form was actively incorporated to the malignant tumor cells, showing high B-10 concentration and T/N ratio, which was suggested of the sufficient effectiveness of boron neutron capture therapy (BNCT) on the malignant brain tumor. The experimental studies were undertaken with rat glioma model which showed that BNCT using 10B-L-BPA brought the good antitumor effect on rat glioma and no side effect on normal brain. Under this PET-BNCT system, the patient with malignant brain tumor was treated.

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Author information

Authors and Affiliations

  1. Department of Neurosurg., Kyoto Prefectural University of Med., Japan

    S. Ueda, Y. Imahori, Y. Ohmori & E. Yoshino

  2. Kyoto University Research Reacter Institute, Japan

    K. Ono, T. Kobayashi & M. Takagaki

  3. Department of Neurosurg., Kyoto University, Japan

    Y. Oda

  4. Cyclotron and RI Center, Tohoku University, Japan

    T. Ido

  5. Mishima Institute for Derm. Research, Japan

    Y. Mishima

Authors
  1. S. Ueda
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  2. Y. Imahori
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  3. Y. Ohmori
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  4. E. Yoshino
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  5. K. Ono
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  6. T. Kobayashi
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  7. M. Takagaki
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  8. Y. Oda
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  9. T. Ido
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  10. Y. Mishima
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Editor information

Editors and Affiliations

  1. Mishima Institute for Dermatological Research, Kobe, Japan

    Yutaka Mishima (President) (President)

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© 1996 Springer Science+Business Media New York

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Ueda, S. et al. (1996). Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_116

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  • DOI: https://doi.org/10.1007/978-1-4757-9567-7_116

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9569-1

  • Online ISBN: 978-1-4757-9567-7

  • eBook Packages: Springer Book Archive

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