The Compound Factor of NA2B12H11SH and the Relative Biological Effectiveness of Recoil Protons for Neurological Damage in Boron Neutron Capture Therapy
Boron neutron capture therapy (BNCT) utilizes the release of particles with a high linear energy transfer (high-LET particles) following the capture of thermal neutrons in boron-10. As in all radiotherapy modalities, the aim of BNCT is to deposit a tumoricidal radiation dose in the tissue to be eliminated, while at the same time sparing the healthy tissue. In contrast to conventional radiotherapy, this is not achieved by physical targeting of the beam, but rather by physiological targeting of the tumor with boron-containing compounds.
KeywordsFast Neutron Boron Concentration Boron Neutron Capture Therapy Relative Biological Effectiveness Recoil Proton
Unable to display preview. Download preview PDF.
- 4.J.A.Coderre, M.S. Makar, P.L. Micca, M.M. Nawrocky, D.D. Joel, D.N. Slatkin, and H.1. Amols, Derivations of RBEs for the high-LET radiation produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo, Int. J. Radiation Onkol. Biol. Phys. 27: 1121–1129, 1993.CrossRefGoogle Scholar
- 8.R.A. Gahbauer, R.G. Fairchild, J.H. Goodman, and T.H. Blue, Can relative biological effectiveness be used for treatment planning in boron neutron capture therapy? in: “Tumor Response Monitoring and Treatment Planning,” A. Breit, ed., Springer Verlag, Berlin, 1992, pp. 755–758.Google Scholar
- 11.R.V. Dorn III, M.L. Griebenow, A.L. Ackermann, F.J. Wheeler, K.M. Bradshaw, T.L. Richards, D.E. Wessol, Y.D. Harker, D.W. Nigg, P.D. Randolph, and W.F. Bauer, The Idaho power burst facility/boron neutron capture therapy (PBF/BNCT) program overview, in: “Progress in Neutron Capture Therapy for Cancer,” D.E. Moore, B.V. Harrington, and B.J. Allen, eds., Plenum Press, New York, 1992, pp. 13–20.CrossRefGoogle Scholar
- 14.A. Siefert, J. Casado, R.L. Moss, P. Gavin, K. Philipp, R. Huiskamp, and E. Dühmke, Healthy tissue tolerance studies for BNCT at the high flux reactor in Petten–first results, in: “Boron Neutron Capture Therapy. Toward Clinical Trials of Glioma Treatment,” D. Gabel and R. Moss, eds., Plenum Press, New York, 1992, pp. 179–185.CrossRefGoogle Scholar
- 15.P.R. Gavin, F.J. Wheeler, R. Huiskamp, A. Siefert, S. Kraft, and C. DeHaan, Large animal model studies of normal tissue tolerance using an epithennal neutron beam and borocaptate sodium, in: “Boron Neutron Capture Therapy. Toward Clinical Trials of Glioma Treatment,” D. Gabel and R. Moss, eds., Plenum Press, New York, 1992, pp. 197–206.CrossRefGoogle Scholar