Development of a Method to Use Boron Neutron Capture Therapy for Diffused Tumours of Liver (Taormina Project)

  • T. Pinelli
  • S. Altieri
  • F. Fossati
  • A. Zonta
  • D. Cossard
  • U. Prati
  • L. Roveda
  • G. Ricevuti
  • R. Nano

Abstract

The research informing this paper is based on the idea to treat, by BNCT, the human liver metastases by neutron irradiation of the organ outside the patient. The program, originally proposed by groups of surgeons and physicists, is supported by I.N.F.N. since 1988*.

The liver, after having been Boron enriched, will be irradiated inside the reactor thermal column, then grafted into the same donor.

The method is described by analysing the main details concerning all inherent problems.

Results concerning survival time during the anhepatic phase as obtained in the swine model, physical quantities defining the reactor facility, details concerning the irradiation position, conditions necessary for a safe treatment, preliminary results on Boron uptake by hepatic tissues in the rat model are given and discussed.

Keywords

Hepatic Tissue Boron Neutron Capture Therapy Irradiation Position Boron Compound Irradiation Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    H. Hatanaka and W. H. Sweet, Slow neutron capture therapy for malignant tumours. Its history and recent development. Proceeding of Symposium of Biomedical Dosimetry, Vienna, 10–14 March, 1975, STI/PUB/4 01, IAEA, Vienna.Google Scholar
  2. 2.
    R.G. Zamenhof,G.R. Solares,O.K.. Harling, Eds., Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy. Advanced Medical Publishing, Madison, Wisconsin, 1994.Google Scholar
  3. 3.
    T. Nguyen, G.L. Brownel, S.A. Holden, S. Kahl, M. Miura, B.A. Teichei, Subcellular distribution of various Boron compounds and implications for their efficacy in Boron Neutron Capture Therapy by Monte Carlo simulations, Radiation Research 133, 1993, 33–40.PubMedCrossRefGoogle Scholar
  4. 4.
    Hassan K. Awwad, Late reacting tissues: radiation-induced liver damage. Radiation Oncology: Radiobiological and Physiological Perspectives, Kluwer Academic Publishers, 1993, 421–427.Google Scholar
  5. 5.
    C. Martinenghi, Basi fisiche e biologiche della Radioterapia e della Radioprotezione. Edizioni libreria Cortina, Milano, 1984.Google Scholar
  6. 6.
    H. Yanagie, Y. Fujii,M. Sekiguchi, H. Nariuchi, T. Kobayashi,K. Kanda, A targeting model of Boron Neutron-Capture Therapy to hepatoma cells in vivo with a boronated anti(alpha-fctoprotein)monoclonal antibody. Journal of Cancer Research and Clinical Oncology, I20; 636–64(1.Google Scholar
  7. 7.
    R.F. Barth, D.M. Adams, A.H. Soloway, F. Alain, M.V. Darby, Boronated Starbust Dendrimer Monoclonal Antibody Immunoconjugates–Evaluation as a Potential Delivery System for Neutron Capture Therapy, Bioconjugate Chemistry 5, 1994, 58–66.PubMedCrossRefGoogle Scholar
  8. 8.
    N.M. Goudgaon, G.F. Elkattan, R.F. Schinazi, Boron containing Pyrimidines,Nucleosides, and Oligonucleotides for Neutron Capture Therapy,Nucleosides and Nucleotides 13, 1994, 849–880.Google Scholar
  9. 9.
    K. Woodburn, A.S. Phadke, A.R. Morgan, An in Vitro Study of Boronated Porphyrins for Potential Use in Boron Neutron Capture Therapy, Bioorganic and Medicinal Chemistry Letters 3. 1993, 2017–2022.CrossRefGoogle Scholar
  10. 10.
    I.M. Wyzlic, W. Tjarks, A.H. Soloway, A.K.M. Anisuzzanam, F.G. Rong, R.F. Barth, Strategies for the Design and Syntesis of Boronated Nucleic Acid and Protein Components as Potential Delivery Agents for Neutron Capture Therapy, International Journal of Radiation Oncology Biology Physics 28, 1994, 1203–1213.CrossRefGoogle Scholar
  11. 11.
    A. Caignard, M.S. Martin, M.F. Michel and E. Martin, Interaction between 2 cellular subpopulation of a rat colonic carcinoma when inoculated to the syngencic host. Int. J. Cancer, 36, 273–279, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    D. Chiaraviglio, F. De Grazia, A. Zonta, S. Altieri, A. Braghieri, F. Fossati, P. Pedroni, T. Pinel li, A. Perotti, M. Specchiarello, G. Perlini and H. Rief, Evaluation of selective Boron absorption in liver tumours. Strahlenther. Onkol. 165, 170–172, 1989.PubMedGoogle Scholar
  13. 13.
    R. Pichlmayr, A. Weimann and B. Ringe, Indications for Liver Transplantation in Hepatobiliary Malignancy. Hepatology, 1994, 20: 33–40.Google Scholar
  14. 14.
    R. Pichlmayr, H. Grosse, J. Hausse et al., Technique and preliminary results of extracorporeal liver surgery (bench procedure) and of surgery on the in-situ perfused liver. Br. J. Sung. 1990, 77: 21–26.CrossRefGoogle Scholar
  15. 15.
    K. Kumada, Y. Yamaoka, T. Morimoto ey al., Partial autotransplantation of the liver in hepatocellular carcinoma complicating cirrhosis. Br. J. Surg. 1992, 79: 566–567.PubMedCrossRefGoogle Scholar
  16. 16.
    R. Pichlmayr, Can Liver transplantation be applied for the treatment of liver cancer’?. Upn.1. Surg. 1992. 22: 187–190.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • T. Pinelli
    • 1
  • S. Altieri
    • 1
  • F. Fossati
    • 1
  • A. Zonta
    • 2
  • D. Cossard
    • 2
  • U. Prati
    • 2
  • L. Roveda
    • 2
  • G. Ricevuti
    • 3
  • R. Nano
    • 4
  1. 1.Department of Nuclear and Theoretical PhysicsUniversity of PaviaI.N.F.N.-PaviaItaly
  2. 2.Department of Surgery Division of General SurgeryUniversity of PaviaItaly
  3. 3.Department of Human PathologyUniversity of PaviaItaly
  4. 4.Department of Animal BiologyUniversity of Pavia and Centre of study for HistochemistryC.N.R., PaviaItaly

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