Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs

BSH and Epithermal Neutrons
  • P. R. Gavin
  • S. L. Kraft
  • C. D. Swartz
  • C. E. Dehaan
  • F. J. Wheeler
  • W. M. Bauer


Normal tissue tolerance studies have been extended to 23 dogs with spontaneously occurring tumors. All animals were treated with a single 10×10 cm dorsal portal following the infusion of borocaptate sodium. Blood-boron concentrations at the time of radiation have varied between 20 and 100 μg/g. Objective tumor response was seen in some animals. Radiation brain necrosis was seen in 3 dogs. The bimodal therapy presents a complex challenge in attempting to achieve dose response assays. The results indicate a large dose-sparing effect from the boron capture reactions within the blood.


Linear Energy Transfer Radiation Necrosis Boron Neutron Capture Therapy Compute Tomogra Choroid Plexus Papilloma 
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  1. 1.
    Barth, R.F.; Soloway, A.H.; Fairchild, R.G.; Brugger, R.M. Boron neutron capture therapy for cancer. realities and prospects. Cancer. 70: 2995–3007; 1992.PubMedCrossRefGoogle Scholar
  2. 2.
    Gabel, D.; Foster, S.; Fairchild, R.G. The Monte Carlo simulator of the biological effect of the 10B(N,)7Li reaction in cells and tissue and its implication for boron neutron capture therapy. Radiat. Res. 111: 14–25; 1987.PubMedCrossRefGoogle Scholar
  3. 3.
    Gavin, P.R.; Kraft, S.L.; Wendling, L.R.; Miller, D.L. Canine spontaneous brain tumors—.A large animal model for BNCT. Stralenther. Onkol. 165: 225–229; 1989.Google Scholar
  4. 4.
    Gavin, P.R.; Kraft, S.L.; DeHaan, C.E.; Swartz, C.D.; Griebenow, M.L.. Large animal normal tissue tolerance with boron neutron capture. Int’l. J. Rad. Oncol. Biol. Phys. 28: 1099–1106; 1994.CrossRefGoogle Scholar
  5. 5.
    Hatanaka, H. Boron-neutron capture therapy for tumors. In: Karim, A.B.M.F., Laws. E., eds. Glioma. New York, NY: Springer Verlag; 1991: 233–249.Google Scholar
  6. 6.
    Heidner, G.L.; Kornegay, J.N.; Page, R.L.; Dodge, R.K.; Thrall, D.E. Analysis of survival in a retrospective study of 86 dogs with brain tumors. J. Vet. Intern. Med. 5: 219–226; 1991.PubMedCrossRefGoogle Scholar
  7. 7.
    Kirsh, J.E.; Brownell, G.L.; Zamenhof, R.G.; Sweet, W.H.; Messr, J.K.; Richardson, E.P.; Takeuchi, A.: Hatanaka, H. Irradiation of the normal canine brain after craniectomy with the current boron neutron capture therapy regimen at MIF reactor. In: Hatanaka, H., ed. Boron-neutron capture therapy for tumors. Nigata, Japan: Nishimura Co., Ltd.; 1986: 147–160.Google Scholar
  8. 8.
    Kitao, K. Vascular wall dose from boron neutron capture reaction. In: Hatanaka, H., ed. Boron neutron capture therapy for tumors. Nigata, Japan: Nishimura Co., Ltd.; 1986: 191–197.Google Scholar
  9. 9.
    Kraft, S.L.; Gavin, P.R.; DeHaan, C.E.; Leathers, C.W.; Bauer. W.F.; Miller, D.L.; Dorn III. R.V.. Borocaptate sodium: A potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. Proc. Natl. Acad. Sci. 89: 11973–11977; 1992.PubMedCrossRefGoogle Scholar
  10. 10.
    Mishima, Y.; Ichihashi, M.; Tsui, M.; Hatta, S.; Ueda, M.; Honda, C.; et al. Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet. 2: 388–389; 1989.PubMedCrossRefGoogle Scholar
  11. 11.
    Philip, K.H.I.; Huiskamp, R.; Casado, J.; Moss, R.L. Normal tissue tolerance in a large animal model of boron neutron capture irradiation with borocaptate sodium (BSH). Abstract: Sixth Int’l. Symp. on Neutron Capture Therapy for Cancer, Kobe, Japan, pg 86, 1994.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. R. Gavin
    • 1
  • S. L. Kraft
    • 2
  • C. D. Swartz
    • 1
  • C. E. Dehaan
    • 3
  • F. J. Wheeler
    • 4
  • W. M. Bauer
    • 4
  1. 1.Department of Veterinary Clinical SciencesWashington State UniversityPullman, WashingtonUSA
  2. 2.Department of RadiologyKansas State UniversityManhattanUSA
  3. 3.PetalumaUSA
  4. 4.Idaho National Engineering LabEG&G Idaho, Inc.Idaho FallsUSA

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