Abstract
Delivery of chemotherapeutic agents or radiation sensitizers to brain neoplasms in amounts sufficient for efficacious therapy remains a continuing challenge. One of the obstacles to be overcome is the inability of large molecules to cross the blood-brain barrier in cerebral capillaries and the blood-tumor barrier in tumor itself. For BNCT to be successful, it is essential that sufficient amounts of boron be delivered to tumors, particularly to disseminated tumor cells at some distance from the main tumor mass. Blood-brain barrier disruption (BBB-D) has been proposed by us (W. Yang, et al., these proceedings) as a means of enhancing compound delivery. We now describe a surgical procedure in rats for BBB-D followed by intracarotid injection of boron compounds and assessment of the degree of disruption.
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References
E.A. Neuwelt, J. Howieson, E.P. Frenkel, H. David Specht, R. Wiegel, Colin G. Buchan, and S.A. Hill, Therapeutic efficacy of multi-agent chemotherapy with drug delivery enhancement of blood-brain barrier modification in glioblastoma, Neurosurgery 19: 573–582, 1986.
E.A. Neuwelt, H.D. Specht, Peggy A. Barnett, S.A. Dahlborg, Abbey Miley, S.M. Larson, P. Brown, K.F. Eckerman, K.E. Hellstrom, and I. Hellstrom, Increased delivery of tumor-specific monoclonal antibodies to brain after osmotic blood-brain barrier modification in patients with melanoma metastatic to the central nervous system, Neurosurgery 20: 885–895, 1987.
Keith L. Black, Wesley A. King, and Kiyonobu Ikezaki, Selective opening of the blood-tumor barrier by intracarotid infusion of leukotrine C4, J. Neurosurg. 72: 912–916, 1990.
J.H. Goodman, J.M. McGregor, N.R. Clendenon, R.A. Gahbauer, R.F. Barth, A.H. Soloway, R.G. Fairchild, Ultrastructural microvascular response to boron neutron capture therapy in an experimental model. Neurosurgery, 24: 701–708, 1989.
J.H. Goodman, J.M. McGregor, N.R. Clendenon, R.A. Gahbauer, R.F. Barth, A.H. Soloway, R.G. Fairchild, Inhibition of tumor growth in a rat glioma model treated with boron neutron capture therapy. Neurosurgery 27 (3): 383–388, 1990.
N.R. Clendenon, R.F. Barth, W.A. Gordon, J.H. Goodman, F. Alam, A.E. Staubus, C. Boesel, A.J. Yates, M.L. Moesehberger, R.C. Fairchild, and J.A. Kalcf-Ezra, Boron neutron capture therapy of a rat glioma, Neurosurgery 26: 47–55, 1990.
N.R. Clendenon, R.F. Barth, J.H. Goodman, A.E. Staubus, W.A. Gordon, M.L. Moeschberger, F. Alain, A.H. Soloway, R.G. Fairchild, D.N. Slatkin. andJ.A. Kalef-Fzra, Enhanced survival in a rat glioma model following BNCT, Strahlenther. Onkol. 2 /3: 222–225, 1989.
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© 1996 Springer Science+Business Media New York
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Carpenter, D.E., Yang, W., Barth, R.F., Ling, B., Castor, M., Goodman, J.H. (1996). Blood-Brain Barrier Disruption (BBB-D) in Rats. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_104
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DOI: https://doi.org/10.1007/978-1-4757-9567-7_104
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