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Molecular Mechanisms in Protection Against Carcinogenesis

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Cancer Biology and Therapeutics

Abstract

The view that the overwhelming majority of human cancers are preventable is as widely accepted today as was the previously held conviction that cancer is an inevitable concomitant of the aging process. Epidemiological studies have led to this revision of our views of the causes of cancer and the prospects for its prevention (1). Because the effective treatment of established, and especially of disseminated, malignancies remains a recalcitrant problem in which progress is debatable (2,3), the development of protective measures against the development of cancer is a compelling goal.

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Abbreviations

BHA:

2(3)-tert-butyl-4-hydroxyanisole

BHT:

3,5-di-tert-butyl-4-hydroxytoluene

DMBA:

7,12-dimethylbenz(a)anthracene; ethoxyquin, 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline; quinone reductase

NAD(P)H:

(quinone acceptor) oxidoreductase (EC 1.6.99.2), also known as menadione reductase, DT diaphorase, or vitamin K reductase.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Paul Talalay, Mary J. De Long & Hans J. Prochaska

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  1. Paul Talalay
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  2. Mary J. De Long
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  3. Hans J. Prochaska
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  1. University of South Florida, Tampa, Florida, USA

    Joseph G. Cory  & Andor Szentivanyi  & 

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© 1987 Springer Science+Business Media New York

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Talalay, P., De Long, M.J., Prochaska, H.J. (1987). Molecular Mechanisms in Protection Against Carcinogenesis. In: Cory, J.G., Szentivanyi, A. (eds) Cancer Biology and Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9564-6_14

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  • DOI: https://doi.org/10.1007/978-1-4757-9564-6_14

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