The Effects of Caloric Restriction on Neoplasia and Age-Related Degenerative Processes

  • Bruce Ruggeri
Chapter
Part of the Human Nutrition book series (HUNU, volume 7)

Abstract

The role of diet in the etiology of cancer is a subject of ongoing controversy and continued research (for reviews, see Reddy and Cohen, 1986; Reddy, 1986; Ip et al., 1986; Cohen, 1987). As noted by Brown (1983), a National Academy of Sciences 2-year study concluded that “although it is difficult to prove firmly a cause-and-effect relationship, the total evidence suggests that some type of dietary components tend to increase the risk of cancer and other types of diets or components tend to decrease the risk” (NAS, 1982). Wynder and Gori (1977) attributed approximately 40% of cancer incidence in men and 60% in women to dietary patterns. Similar estimates for the incidence of potentially preventable cancers in relation to dietary practices have been made by other workers (Bailar, 1979; Cimino and Demopoulous, 1980). Most animal studies indicate that dietary factors probably act at the promotional stage of carcinogenesis (Brown, 1983), although more recent studies (Kritchevsky et al., 1984; Welsch, 1987; Albanes, 1987a,b; Hocman, 1988) suggest that dietary factors (i.e., high-fat, high-calorie intake) may influence both initiation and promotion of tumorigenesis.

Keywords

Breast Cancer Risk Mammary Tumor Caloric Restriction Dietary Restriction Tumor Incidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albanes, D., 1987a, Total calories, body weight, and tumor incidence in mice, Cancer Res. 47: 1987–1992.Google Scholar
  2. Albanes, D., 1987b, Caloric intake, body weight, and cancer: A review, Nutr. Cancer 9: 199–217.Google Scholar
  3. Albanes, D., Jones, D. Y., Schatzkin, A., Micozzi, M. S., and Taylor, P. R., 1988, Adult stature and risk of cancer, Cancer Res. 48: 1658–1662.Google Scholar
  4. Andreou, K. K., and Morgan, P. R., 1981, Effect of dietary restriction on induced hamster cheek pouch carcinogenesis, Arch. Oral Biol. 26: 525–531.Google Scholar
  5. Armario, A., Montero, J. L., and John, T., 1987, Chronic food restriction and circadian rhythms of pituitaryadrenal hormones, growth hormone and thyroid-stimulating hormone, Ann. Nur. Metab. 31: 81–87.Google Scholar
  6. Atterwill, C. K., Brown, C. G., Conybeare, G., and Meakin, J., 1986, Diet-restriction of rats decelerates agerelated changes in serum prolactin levels and CNS dopamine receptor function, Br. J. Pharmacol. 89: 733.Google Scholar
  7. Aylsworth, C. F., Sylvester, P. W., Leung, F. C., and Meites, J., 1980, Inhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels, Cancer Res. 40: 1863–1866.Google Scholar
  8. Bailar, J., 1979, The case for cancer prevention, J. Natl. Cancer Inst. 62: 727–730.Google Scholar
  9. Beth, M., Berger, M. R., Aksoy, M., and Schmahl, D., 1987, Comparison between the effects of dietary fat level and of caloric intake on methylnitrosourea-induced mammary carcinogenesis in female S.D. rats, Int. J. Cancer 39: 737–744.Google Scholar
  10. Bischoff, F., Long, M. L., and Maxwell, L. C., 1935, Influence of caloric intake upon the growth of sarcoma 180, Am. J. Cancer 24: 549–553.Google Scholar
  11. Boissoneault, G. A., Elson, C. E., and Pariza, M. W., 1986, Net energy effects of dietary fat on chemically-induced mammary carcinogenesis in F344 rats, J. Natl. Cancer Inst. 76: 335–338.Google Scholar
  12. Boutwell, R. K., Brush, M. K., and Rusch, H. P., 1949a, The stimulating effect of dietary fat on carcinogenesis, Cancer Res. 9: 741–746.Google Scholar
  13. Boutwell, R. K., Brush, M. K., and Rusch, H. P., 1949b, Some physiological effects associated with chronic caloric restriction, Am. J. Physiol. 154: 517–524.Google Scholar
  14. Brown, R. R., 1983, The role of diet in cancer causation, Food Technol. 37: 49–56.Google Scholar
  15. Bullough, W. S., 1950, Mitotic activity and carcinogenesis, Br. J. Cancer 4: 329–336.Google Scholar
  16. Bullough, W. S., and Eisa, E. A., 1950, The effects of a graded series of restricted diets on epidermal mitotic activity in the mouse, Br. J. Cancer 4: 321–328.Google Scholar
  17. Carroll, K. K., 1975, Experimental evidence of dietary factors and hormone-dependent cancers, Cancer Res. 35: 3374–3383.Google Scholar
  18. Carroll, K. K., 1981, Neutral fats and cancer, Cancer Res. 41: 3695–3699.Google Scholar
  19. Carroll, K. K., 1986, Dietary fat and cancer: specific action or caloric effect? J. Nutr. 116: 1130–1132.Google Scholar
  20. Carter, J. H., and Carter, H. W., 1988, Adrenal regulation of mammary tumorigenesis in female SpragueDawley rats: Histopathology of mammary tumors, Cancer Res. 48: 3808–3815.Google Scholar
  21. Carter, J. H., Carter, H. W., and Meade, J., 1988, Adrenal regulation of mammary tumorigenesis in female Sprague-Dawley rates: incidence, latency, and yield of mammary tumors, Cancer Res. 48: 3801–3807.Google Scholar
  22. Chan, P. C., Head, J. F., Cohen, L. A., and Wynder, E. L., 1977, Influence of dietary fat on the induction of rat mammary tumors by N-nitrosomethylurea: Associated hormone changes and differences between SpragueDawley and F-344 rats, J. Natl. Cancer Inst. 59: 1279–1283.Google Scholar
  23. Chipalkatti, S., De, A. K., and Aiyar, A. S., 1983, Effect of diet restriction on some biochemical parameters related to aging in mice, J. Nutr. 113: 944–950.Google Scholar
  24. Cimino, J. A., and Demopoulous, H. B., 1980, Introduction: Determinants of cancer relevant to prevention in the war on cancer, J. Environ. Pathol. Toxicol. 3: 1–10.Google Scholar
  25. Clinton, S. K., Imrey, P. B., Alster, J. M., Simon, J., Truex, C. R., and Visek, W. J., 1984, The combined effects of dietary protein and fat on 7,12-dimethylbenzanthracene-induced breast cancer in rats, J. Nutr. 114: 1213–1223.Google Scholar
  26. Cohen, L. A., 1987, Diet and cancer, Sci. Am. 257: 42–48.Google Scholar
  27. Cohen, L. A., Keewhan, C., and Wang, C-X., 1988, Influence of dietary fat, colorie restrictor, and voluntary exercise on N-nitro-somethylurea-induced mammary tumorigenesis in rats, Cancer Res. 48: 4276–4283.Google Scholar
  28. Cohen, N. D., and Hilf, R., 1974, Influence of insulin on growth and metabolism of 7,12-dimethylbenz(a) anthracene-induced mammary tumors, Cancer Res. 34: 3245–3252.Google Scholar
  29. Connor-Johnson, B., Gajjar, A., Kubo, C., and Good, R. A., 1986, Calories versus protein in onset of renal disease in NZB x NZW mice, Proc. Natl. Acad. Sci. USA 83: 5659–5662.Google Scholar
  30. Copinschi, G., and Chatelain, P. (eds.), 1985, Recent developments in the study of growth factors: GRF and somatomedins, Hormone Res. 24:77–228.Google Scholar
  31. Corcos, D., Vaulont, S., Denis, N., Lyonnet, S., Simon, M-P., Kitzis, A., Kahn, A., and Kruh, J., 1987, Expression of c-myc is under dietary control in rat liver, Oncogene Res. 1: 193–199.Google Scholar
  32. Dao, T. L., and Sinha, D., 1975, Effect of carcinogen on pituitary prolactin release and synthesis, Proc. Am. Assoc. Cancer Res. 16: 28.Google Scholar
  33. DeWaard, F., Cornelis, J. P., Aoki, K., and Yoshida, M., 1977, Breast cancer incidence according to weight and height in two cities of the Netherlands and in Aichi Prefecture, Jpn. Cancer 40: 1269–1275.Google Scholar
  34. Doll, R., and Peto, R., 1981, The causes of cancer: quantitative estimates of avoidable risks of cancer in the U.S. today, J. Natl. Cancer Inst. 66: 1191–1308.Google Scholar
  35. Donato, K., 1987, Efficiency of utilization of various energy sources for growth, Am. J. Clin. Nutr. 45 (Suppl.): 164–167.Google Scholar
  36. Donato, K., and Hegsted, D. M., 1985, Efficiency of utilization of various sources of energy for growth, Proc. Natl. Acad. Sci. 82: 4866–4870.Google Scholar
  37. Erickson, K. L., 1984, Dietary fat influence on murine melanoma growth and lymphocyte-mediated cytotoxicity, J. Natl. Cancer Inst. 72: 115–120.Google Scholar
  38. Erickson, K. L., and Thomas, I. K., 1985, The role of dietary fat in mammary tumorigenesis, Food Technol. 39: 69–73.Google Scholar
  39. Ershler, W. B., Berman, E., and Moore, A. L., 1986, Slower B16 melanoma growth but greater pulmonary colonization in calorie-restricted mice, J. Natl. Cancer Inst. 76: 81–85.Google Scholar
  40. Fernande, G., Yunis, E. J., and Good, R. A., 1976, Suppression of adenocarcinoma by the immunological consequences of caloric restriction, Nature 263: 504–506.Google Scholar
  41. Fernandes, G., Khare, A., Langaniere, S., Yu, B., Sandberg, L., and Friedrichs, B., 1987, Effect of food restriction and aging on immune cell fatty acids, functions and oncogene expression in SPF Fischer 344 rats, Fed. Proc. 46: 567.Google Scholar
  42. Forbes, E. B., Swift, R. W., Elliott, R. F., and James, W. H., 1946, Relation of fat to economy of food utilization. II. By the mature albino rat, J. Nutr. 31: 213–227.Google Scholar
  43. Furlanetto, R. W., DiCarlo, J. N., and Wisehart, C., 1987, The type II insulin-like growth factor receptor does not mediate deoxyribonucleic ancid synthesis in human fibroblasts, J. Clin. Endocrinol. Metab. 64: 1142–1149.Google Scholar
  44. Gajjar, A., Kubo, C., Johnson, B. C., and Good, R. A., 1987, Influence of extremes of protein and energy intake on survival of B/W mice, J. Nutr. 117: 1136–1140.Google Scholar
  45. Garfinkel, L., 1985, Overweight and cancer, Ann. Intern. Med. 103: 1034–1036.Google Scholar
  46. Gerbase-DeLima, M., Liu, R. K., Cheney, K. E., Michey, R., and Walford, R. L., 1975, Immune function and survival in a long-lived mouse strain subjected to undernutrition, Gerontologia 21: 184–202.Google Scholar
  47. Gibson, S. L., and Hilf, R., 1980, Regulation of estrogen-binding capacity by insulin in 7,12-dimethylbenz(a)-anthracene-induced mammary tumors in rats, Cancer Res. 40: 2343–2348.Google Scholar
  48. Giovanella, B. C., Shepard, R. C., Stehlin, J. S., Venditti, J. M., and Abbott, B. J., 1982, Calorie restriction: Effect on growth of human tumors heterotransplanted in nude mice, J. Natl. Cancer Inst. 68: 249–257.Google Scholar
  49. Goodwin, P. J., and Boyd, N. F., 1987, Critical appraisal of the evidence that dietary fat intake is related to breast cancer risk in humans, J. Natl. Cancer Inst. 79: 473–485.Google Scholar
  50. Graham, S., Marshall, J., Mettlin, C., Rzepka, T., Nemoto, T., and Byers, T., 1982, Diet in the epidemiology of breast cancer, Am. J. Epidemiol. 116: 68–75.Google Scholar
  51. Greenberg, E. R., Vessey, M. P., McPherson, K., Doll, R., and Yeates, D., 1985, Body size and survival and premenopausal breast cancer, Br. J. Cancer 51: 691–697.Google Scholar
  52. Gross, L., and Dreyfuss, Y., 1984, Reduction in the incidence of radiation-induced tumors in rats after restriction of food intake, Proc. Natl. Acad. Sci. USA 81: 7596–7598.Google Scholar
  53. Harrison, D. E., Archer, J. R., and Astle, C. M., 1984, Effects of food restriction on aging: separation of food intake and adiposity, Proc. Natl. Acad. Sci. USA 81: 1835–1828.Google Scholar
  54. Hebert, J. R., Augustine, A., Barone, J., Kabat, G. C., Kinne, D. W., and Wynder, E. L., 1988, Weight, height and body mass index in the prognosis of breast cancer: early results of prospective study, Int. J. Cancer 42: 315–318.Google Scholar
  55. Heuson, J. C., and Legros, N., 1968, Study of the growth-promoting effect of insulin in relation to carbohydrate metabolism in organ culture of rat mammary carcinoma, Eur. J. Cancer 4: 1–7.Google Scholar
  56. Heuson, J. C., and Legros, N., 1971, Effect of insulin on DNA synthesis and DNA oplymerase activity in organ culture of rat mammary carcinoma, and the influence of insulin pre-treatment and of alloxan diabetes, Cancer Res. 31: 59–65.Google Scholar
  57. Heuson, J. C., and Legros, N., 1972a, Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction, Cancer Res. 32: 226–232.Google Scholar
  58. Heuson, J. C., and Legros, N., 1972b, Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction, Cancer Res. 32: 226–232.Google Scholar
  59. Heuson, J. C., Legros, N., and Heimann, R., 1972, Influence of insulin administration on growth of the 7,12dimethylbenz(a)anthracene-induced mammary carcinoma in intact, oophorectomized, and hypophysectomized rats, Cancer Res. 32: 233–238.Google Scholar
  60. Hilf, R., Hissin, P. J., and Shafie, S. M., 1978, Regulatory interrelationships for insulin and estrogen action in mammary tumors, Cancer Res. 38: 4076–4085.Google Scholar
  61. Hill, D. J., and Milner, R. D. G., 1985, Insulin as a growth factor, Pediatr. Res. 19: 879–886.Google Scholar
  62. Hirohata, T., Shigematsu, T., Nomura, A. M. Y., Normura, Y., Horie, A., and Hirohata, I., 1985, Occurrence of breast cancer in relation to diet and reproductive history: A case-control study in Fukuoka, Japan, NCI Monogr. 69: 187–190.Google Scholar
  63. Hirohata, T., Nomura, A. M. Y., Hankin, J. H., Kolonel, L. N., and Lee, J., 1987, An epidemiologic study on the association between diet and breast cancer, J. Natl. Cancer Inst. 78: 595–600.Google Scholar
  64. Hocman, G., 1988, Prevention of cancer: Restriction of nutritional energy intake (joules), Comp. Biochem. Physiol. 91A: 209–220.Google Scholar
  65. Holehan, A. M., and Merry, B. J., 1985, The control of puberty in the dietary restricted female rat, Mech. Ageing Del). 32: 179–191.Google Scholar
  66. Hopkins, G. J., and Carroll, K. K., 1979, Relationship between amount and type of dietary fat in promotion of mammary carcinogenesis induced by 7,12-dimethylbenzanthracene, J. Natl. Cancer Inst. 62: 1009–1012.Google Scholar
  67. Hopkins, G. J., Kennedy, T. G., and Carroll, K. K., 1981, Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7,12-dimethylbenzanthracene, J. Natl. Cancer Inst. 66: 517–522.Google Scholar
  68. Horikawa, S., Sakata, K., Hatanaka, M., and Tsukada, K., 1986, Expression of c-myc oncogene in rat liver by a dietary manipulation, Biochem. Biophys Res. Commun. 140: 574–580.Google Scholar
  69. Ip, C., Carter, C. A., and Ip, M. M., 1985, Requirement of essential fatty acid for mammary tumorigenesis in the rat, Cancer Res. 45: 1997–2001.Google Scholar
  70. Ip, C., Birt, D. F., Rogers, A. E., and Mettlin, C., (eds.), 1986, Dietary fat and cancer, In: Progress in Clinical and Biological Research, Volume 222, Alan R. Liss, New York, 885 pp.Google Scholar
  71. Jose, D. G., and Good, R. A., 1973, Quantitative effects of nutritional protein and calorie deficiency upon immune responses to tumors in mice, Cancer Res. 33: 807–812.Google Scholar
  72. Kahn, C. R., 1985, The molecular mechanism of insulin action, Ann. Rev. Med. 36: 429–451.Google Scholar
  73. Kelsey, J. L., and Berkowitz, 1988, Breast cancer epidemiology, Cancer Res. 48: 5615–5623.Google Scholar
  74. Khare, A., Mountz, J., Fischbach, M., Talal, N., and Fernandes, G., 1987, Effect of dietary lipids and calories on oncogene expression in autoimmune LPR mice, Fed. Proc. 46: 441.Google Scholar
  75. King, M. M., and McCay, P. B., 1986, Potentiation of carcinogenesis by dietary fat: Is it caused by high energy consumption or is it an effect of fat itself? J. Nutr. 116: 2313–2315.Google Scholar
  76. Klein, G., and Klein, E., 1985, Evolution of tumors and the impact of molecular oncology, Nature 315: 190–195.Google Scholar
  77. Klurfeld, D. M., Weber, M. M., and Kritchevsky, D., 1987, Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat, Cancer Res. 47: 2759–2762.Google Scholar
  78. Klurfeld, D. M., Welch, C. B., Davis, M. F., and Kritchevsky, D., 1989, Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase, J. Nutr. 119: 286–291.Google Scholar
  79. Koga, A., and Kimura, S., 1979, Influence of restricted diet on the cell renewal of the mouse small intestine, J. Nutr. Sci. Vitaminol. 25: 265–267.Google Scholar
  80. Koga, A., and Kimura, S., 1980, Influence of restricted diet on the cell cycle in the crypt of mouse small intestine, J. Nutr. Sci Vitaminol. 26: 33–38.Google Scholar
  81. Koizumi, A., Weindruch, R., and Walford, R. L., 1987, Influence of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice, J. Nutr. 117: 361–367.Google Scholar
  82. Kolonel, L. N., Nomura, A. M. Y., Lee, J., and Hirohata, T., 1986, Anthropometric indicators of breast cancer risk in postmenopausal women in Hawaii, Nutr. Cancer 8: 247–256.Google Scholar
  83. Kritchevsky, D., 1982, Lipids and cancer, In: Molecular Interrelations of Nutrition and Cancer ( N. S. Arnott, J. van Eys, and Y-M. Yang, eds.), Raven Press, New York, pp. 209–216.Google Scholar
  84. Kritchevsky, D., and Klurfeld, D. M., 1987, Caloric effects of experimental mammary tumorigenesis, Am. J. Clin. Nutr. 45: 236–243.Google Scholar
  85. Kritchevsky, D., Weber, M. M., and Klurfeld, D. M., 1984, Dietary fat versus caloric content in initiation and promotion of 7,12-dimethylbenzanthracene-induced mammary tumorigenesis in rats, Cancer Res. 44: 3174–3177.Google Scholar
  86. Kritchevsky, D., Buck, C. M., Weber, M. M., and Klurfeld, D. M., 1986, Calories, fat and cancer, Lipids 21: 272–274.Google Scholar
  87. Kubo, C., Johnson, B. C., Gajjar, A., and Good, R. A., 1987, Crucial dietary factors in maximizing life span and longevity in autoimmune-prone mice, J. Nutr. 117: 1129–1135.Google Scholar
  88. Lagopoulous, L., and Stalder, R., 1987, The influence of food intake on the development of diethylnitrosamineinduced liver tumors in mice, Carcinogenesis 8: 33–37.Google Scholar
  89. Lane, J. W., Bute, J. S., Howard, C., Shepherd, F., Halligan, R., and Medina, D., 1985, The role of high levels of dietary fat in 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis. Lack of an effect on lipid peroxidation, Carcinogenesis 6: 403–407.Google Scholar
  90. Larsen, C. D., and Heston, W. E., 1946, Effects of cystine and calorie restriction on the incidence of spontaneous pulmonary tumors in strain A mice, J. Natl. Cancer Inst. 6: 31–40.Google Scholar
  91. Lavik, P. S., and Baumann, C. A., 1943, Further studies on the tumor-promoting action of fat, Cancer Res. 3: 739–756.Google Scholar
  92. Leung, B. S., and Sasaki, G. H., 1975, On the mechanism of prolactin and estrogen action in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in the rat. II. In vitro tumor responses and estrogen receptor, Endocrinology 97: 564–572.Google Scholar
  93. Leung, F. C., Aylsworth, C. F., and Meites, J., 1983, Counteraction of underfeeding-induced inhibition of mammary tumor growth in rats by prolactin and estrogen administration, Proc. Soc. Exp. Biol. Med. 173: 159–163.Google Scholar
  94. Lew, E. A., and Garfinkel, L., 1979, Variations in mortality by weight among 750,000 men and women, J. Chronic Dis. 32: 563–576.Google Scholar
  95. Licastro, F., Weindruch, R., and Walford, R. L., 1986, Dietary restriction retards the age-related decline of the DNA repari capacity in mouse splenocytes, In: Immunoregulation in Aging (A. Facchini, J. J. Haaijman, and G. Labo, eds.)., Eurage, Rijswijk, The Netherlands, pp. 53–61.Google Scholar
  96. Loeb, J. N., 1976, Corticosteroids and growth, N. Engl. J. Med. 205: 547–552.Google Scholar
  97. Loeb, L., Suntzeff, V., Blumenthal, H. T., and Kirtz, M. M., 1942, Effect of weight on the development of mammary carcinoma in various strains of mice, Arch. Pathol. 33: 845–865.Google Scholar
  98. Lok, E., Nera, E. A., Iverson, F., Scott, F., So, Y., and Clayson, D. B., 1988, Dietary restriction, cell proliferation and carcinogenesis: A preliminary study, Cancer Lett. 38: 249–255.Google Scholar
  99. Lupelescu, A. P., 1985a, Effect of prolonged insulin treatment on carcinoma formation in mice, Cancer Res. 45: 3288–3295.Google Scholar
  100. Lupelescu, A. P., 1985b, Enhancement of epidermal carcinoma formation by prolactin in mice, J. Natl. Cancer Inst. 74: 1335–1346.Google Scholar
  101. Lyon, J. E., Mahoney, A. W., West, D. W., Gardner, J. W., Smith, K. R., Sorenson, A. W., and Stanish, W., 1987, Energy intake: Its relationship to colon cancer risk, J. Natl. Cancer Inst. 78: 853–861.Google Scholar
  102. Manni, A., Trujillo, J. E., and Pearson, O. H., 1977, Predominant role of prolactin in stimulating the growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor, Cancer Res. 37: 1216–1219.Google Scholar
  103. Masoro, E. J., 1985, Nutrition and aging: A current assessment, J. Nutr. 115: 842–848.Google Scholar
  104. Masoro, E. J., Yu, B. P., and Bertrand, H. A., 1982, Action of food restriction in delaying the aging process, Proc. Natl. Acad. Sci. USA 79: 4239–4241.Google Scholar
  105. McCay, C. M., and Crowell, M. F., 1934, Prolonging the lifespan, Sci. Monthly 39: 405–414.Google Scholar
  106. McCay, C. M., Maynard, L. A., Sperling, G., and Barnes, L. L., 1939, Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets in calories, J. Nutr. 18: 1–13.Google Scholar
  107. McCumbee, W. D., and Lebovitz, H. E., 1981, Chondrosarcoma growth: influence of diabetes, caloric restriction and insulin treatment, Am. J. Physiol. (Endocrinol. Metab.) 4: E129 - E135.Google Scholar
  108. Meites, J., 1972, Relation of prolactin and estrogen to mammary tumorigenesis in the rat, J. Natl. Cancer Inst. 48: 1217–1224.Google Scholar
  109. Mills, P. K., Annegers, J. F., and Phillips, R. L., 1988, Animal product consumption and subsequent fatal breast cancer risk among Seventh-Day Adventists, Am. J. Epidemiol. 127: 440–453.Google Scholar
  110. Moreschi, C., 1909, Beziehungern awischen ernahrung unt tumorwachstum, Z. Immunitatforsch. 2: 651.Google Scholar
  111. Mutsuura, S., Sone, S., Tsubura, E., Tacibana, K., and Kishino, Y., 1986, Activation of antitumor properties in alveolar macrophages from protein-calorie malnourished rats, Cancer Immunol. Immunother. 21: 63–68.Google Scholar
  112. NAS, 1982, Committee on Diet, Nutrition and Cancer, National Academy Press, Washington, DC., pp. 66–72.Google Scholar
  113. Newman, S. C., Miller, A. B., and Howe, G. R., 1986, A study of the effect of weight and dietary fat on breast cancer survival time, Am. J. Epidemiol. 123: 767–774.Google Scholar
  114. Ohno, T., and Cardullo, A. C., 1983, Effect of caloric restriction on neoplasm growth, Mt. Sinai J. Med. 50: 338–342.Google Scholar
  115. Pahlavani, M. A., and Richardson, A., 1987, Influence of dietary restriction on the function of the immune system of rats, Fed. Proc. 46: 567.Google Scholar
  116. Pariza, M. W., 1986, Calorie restriction, ad libitum feeding, and cancer, Proc. Soc. Exp. Biol. Med. 183: 293–298.Google Scholar
  117. Pariza, M. W., 1987, Dietary fat, calorie restriction, ad libitum feeding, and cancer risk, Nutr. Rev. 45: 1–7.Google Scholar
  118. Pasqualini, C., Bojda, R., and Kerdelhue, B., 1988, In vitro estrogen-like effects of 7,12-dimethylbenz(a)anthracene on anterior pituitary dopamine receptors of rats, Cancer Res. 48: 6434–6437.Google Scholar
  119. Pearson, O. H., Llerena, O., Llerena, L., Molina, A., and Bulter, T., 1969, Prolactin-dependent rat mammary cancer: A model for man? Trans. Assoc. Am. Physicians 82: 225–238.Google Scholar
  120. Pollard, M., and Luckert, P. H., 1985, Tumorigenic effects of direct-and indirect-acting chemical carcinogens in rats on a restricted diet, J. Natl. Cancer Inst. 74: 1347–1349.Google Scholar
  121. Pollard, M., Luckert, P. H., and Pan, G-Y., 1984, Inhibition of intestinal tumorigenesis in methylazoxymethanol-treated rats by dietary restriction, Cancer Treat. Rep. 68: 405–408.Google Scholar
  122. Rao, G. N., Piegorsch, W. W., and Haseman, J. K., 1987, Influence of body weight on the incidence of spontaneous tumors in rats and mice of long-term studies, Am. J. Clin. Nutr. 45 (Suppl.): 252–260.Google Scholar
  123. Rao, G., Heydari, A., Gu, M. Z., Waggoner, S., Marquardt, L., and Richardson, A., 1988, Effect of dietary restriction on gene expression, FASEB J. 2:Al209.Google Scholar
  124. Reddy, B. S., 1986, Dietary fat and cancer: specific action or caloric effect? J. Nutr. 116: 1132–1135.Google Scholar
  125. Reddy, B. S., and Cohen, L. A. (eds.), 1986, Diet, Nutrition and Cancer: A Critical Evaluation. Vol 1. Macronutrients and Cancer, CRC Press, Boca Raton, FL, 175 pp.Google Scholar
  126. Reddy, B. S., Wan, C-X., and Maruyama H., 1987, Effect of restricted caloric intake on azoxymethane-induced colon tumor incidence in male F344 rats, Cancer Res. 47: 1226–1228.Google Scholar
  127. Richardson, A., and Cheung, H. T., 1982, The relationship between age-related changes in gene expression, protein turnover, and the responsiveness of an organism to stimuli, Life Sci. 31: 605–613.Google Scholar
  128. Roebuck, B. D., Yager, J. D., Jr., and Longnecker, D. S., 198la, Dietary modulation of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41: 888–893.Google Scholar
  129. Roebuck, B. D., Yager, Jr., J. D., Longnecker, J. D., and Wilpone, S. E., 1981b, Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41: 3961–3966.Google Scholar
  130. Rohan, T. E., and Bain, C. J., 1987, Diet in the etiology of breast cancer, Epidemiol. Rev. 9:120–145. Rosen, O. M., 1987, After insulin binds, Science 237: 1452–1458.Google Scholar
  131. Ross, M. H., and Bras, G., 1971, Lasting influence of early caloric restriction on prevalence of neoplasms in the rat, J. Natl. Cancer Inst. 47: 1095–1113.Google Scholar
  132. Ross, M. H., and Bras, G., 1973, Influence of protein under-and ovemutrition on spontaneous tumor prevalence in the rat, J. Nutr. 103: 944–963.Google Scholar
  133. Ross, M. H., Lustbader, E. D., and Bras, G., 1983, Body weight, dietary practices, and tumor suspectibility in the rat, J. Natl. Cancer Inst. 71: 1041–1046.Google Scholar
  134. Rous, P., 1914, The influence of diet on transplanted and spontaneous mouse tumors, J. Exp. Med. 20: 433.Google Scholar
  135. Rudland, P. S., Hallowes, R. C., Durbin, H., and Lewis, D., 1977, Mitogenic activity of pituitary hormones on cell cultures of normal and carcingen-induced tumor epithelium from rat mammary glands, J. Cell Biol. 73: 561–577.Google Scholar
  136. Ruggeri, B. A., Klurfeld, D. M., and Kritchevsky, D., 1987, Biochemical alterations in 7,12-dimethylbenz(a)anthracene-induced mammary tumors from rats subjected to caloric restriction, Biochem. Biophys. Acta. 929: 239–246.Google Scholar
  137. Sarkar, N. H., Fernandes, G., Telang, N. T., Kourides, I. A., and Good, R. A., 1982, Low calorie diet prevents the development of mammary tumors in C3H mice and reduces circulating prolactin level, murine mammary tumor virus expression, and proliferation of mammary alveolar cells, Proc. Natl. Acad. Sci. USA 79: 7758–7762.Google Scholar
  138. Saxton, J. A., Boon, M. C., and Furth, J., 1944, Observations on the inhibition of development of spontaneous leukemia in mice by underfeeding, Cancer Res. 7: 401–409.Google Scholar
  139. Schneider, E. L., and Reed, J. D., Jr., 1985, Life extension, N. Engl. J. Med. 312: 1159–1168.Google Scholar
  140. Shafie, S. M., and Hilf, R., 1978, Relationship between insulin and estrogen binding to growth response in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors, Cancer Res. 38: 759–764.Google Scholar
  141. Sinha, D. K., Gebhard, R. L., and Pazik, J. E., 1988, Inhibition of mammary carcinogenesis in rats by dietary restriction, Cancer Lett. 40: 133–141.Google Scholar
  142. Steffen, M., Scherdin, V., Duvigneau, C., and Holzel, F., 1988, Glucocorticoid-induced alterations of morphology and growth of fibrosarcoma cells derived from 7,12-dimethylbenz(a)anthracene rat mammary tumor, Cancer Res. 48: 7212–7218.Google Scholar
  143. Stewart, J., Meaney, M. J., Aitken, D., Jensen, L., and Kalant, N., 1988, The effects of acute and life-long food restriction on basal and stress-induced serum corticosterone levels in young and aged rats, Endocrinology 123: 1934–1941.Google Scholar
  144. Swanson, C. A., Jones, D. Y., Schatzkin, A., Brinton, L. A., and Ziegler, R. G., 1988, Breast cancer risk assessed by anthropometry in the NHANES I epidemiological follow-up study, Cancer Res. 48: 5363–5367.Google Scholar
  145. Sylvester, P. W., Aylsworth, C. F., and Meites, J., 1981, Relationship of hormones to inhibition of mammary tumor development by underfeeding during the “critical period” after carcinogen administration, Cancer Res. 41: 1383–1388.Google Scholar
  146. Sylvester, P. W., Aylsworth, C. F., Van Vugt, D. A., and Meites, J., 1982, Influence of underfeeding during the “critical period” or thereafter on carcinogen-induced mammary tumors in rats, Cancer Res. 42: 4943–4947.Google Scholar
  147. Tannenbaum, A., 1940a, Relationship of body weight to cancer incidence, Arch. Pathol. 30: 509–517.Google Scholar
  148. Tannenbaum, A., 1940b, The initiation and growth of tumors. Introduction. I. Effects of underfeeding, Am. J. Cancer 38: 335–350.Google Scholar
  149. Tannenbaum, A., 1942, The genesis and growth of tumors. II. Effects of calorie restriction per se, Cancer Res. 2: 460–467.Google Scholar
  150. Tannenbaum, A., 1944, The dependence on the genesis of induced skin tumors on the fat content of the diet during different stages of carcinogenesis, Cancer Res. 4: 683–687.Google Scholar
  151. Tannenbaum, A., 1945a, The dependence of tumor formation on the degree of caloric restriction, Cancer Res. 5: 609–615.Google Scholar
  152. Tannenbaum, A., 1945b, The dependence of tumor formation on the composition of the calorie-restricted diet as well as on the degree of restriction, Cancer Res. 5: 616–625.Google Scholar
  153. Tannenbaum, A., and Silverstone, H., 1949, Effect of low environmental temperature, dinitrophenol, or sodium fluoride on the formation of tumors in mice, Cancer Res. 9: 403–410.Google Scholar
  154. Tao, S-C., Yu, M. C., Ross, R. K., and Xiu, K-W., 1988, Risk factors for breast cancer in Chinese women in Beijing, Int. J. Cancer 42: 495–498.Google Scholar
  155. Taub, R., Roy, A., Dieter, R., and Koontz, J., 1987, Insulin as a growth factor in rat hepatoma cells, J. Biol. Chem. 262: 10893–10897.Google Scholar
  156. Thompson, H. J., Meeker, L. D., Tagliaferro, A. R., and Roberts, J. S., 1985, Effect of energy intake on the promotion of mammary carcinogenesis by dietary fat, Nutr. Cancer 7: 37–41.Google Scholar
  157. Tucker, M. J., 1979, The effect of long-term food restriction on tumors in rodents, Int. J. Cancer 23: 803–807.Google Scholar
  158. Visscher, M. B., Ball, Z. B., Barnes, R. H., and Silvertsen, I., 1942, The influence of caloric restriction upon the incidence of spontaneous mammary carcinoma in mice, Surgery 11: 48–55.Google Scholar
  159. Waxier, S. H., 1954, The effect of weight reduction on the occurrence of spontaneous mammary tumors in mice, J. Natl. Cancer Inst. 14: 1253–1256.Google Scholar
  160. Waxier, S. H., 1960, Obesity and cancer susceptibility in mice, Am. J. Clin. Nutr. 8: 760–766.Google Scholar
  161. Weindruch, R. H., Kristie, J. A., Cheney, K. E., and Walford, R. L., 1979, Influence of controlled dietary restriction on immunologic function and aging, Fed. Proc. 38: 2007–2016.Google Scholar
  162. Weindruch, R. H., Devens, B. H., Raff, H. V., and Walford, R. L., 1983, Influence of dietary restriction on aging and natural killer cell activity in mice, J. Immunol. 130: 993–996.Google Scholar
  163. Weindruch, R. H., Walford, R. L., Fligiel, S., and Guthrie, D., 1986, The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake, J. Nutr. 116: 641–654.Google Scholar
  164. Welsch, C. W., 1985, Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: A review and tribute to Charles Brenton Huggins, Cancer Res. 45: 3415–3443.Google Scholar
  165. Welsch, C. W., 1987, Enhancement of mammary tumorigenesis by dietary fat: a review of potential mechanisms, Am. J. Clin. Nutr. 45 (Suppl.): 192–202.Google Scholar
  166. Welsch, C. W., and Aylsworth, C. F., 1983, The interrelationship between dietary lipids, endocrine activity, and the development of mammary tumors in experimental animals, In: Dietary Fats and Health (E. G. Perkins and W. J. Visek, eds.), AOCS Monograph 10, Champaign, IL, pp. 790–816.Google Scholar
  167. Weraarchakul, N., and Richardson, A., 1988, Effect of age and dietary restriction on DNA repair, FASEB J. 2:Al209.Google Scholar
  168. White, F. R., 1961, The relationship between underfeeding and tumor formation, transplantation, and growth in rats and mice, Cancer Res. 21: 281–290.Google Scholar
  169. White, F. R., White, J., Mider, G. B., Kelly, M. G., and Heston, W. E., 1944, Effect of caloric restriction on mammary tumor formation in strain C3H mice and on the response of strain DBA to painting with methylcholanthrene, J. Natl. Cancer Inst. 5: 43–47.Google Scholar
  170. Willet, W. C., 1987, Implications of total energy intake for epidemiologic studies of breast and large-bowel cancer, Am. J. Clin. Nutr. 45 (Suppl.): 354–360.Google Scholar
  171. Willet, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A., Hennekens, C. H., and Speizer, F. E., 1987, Dietary fat, and the risk of breast cancer, N. Engl. J. Med. 316: 22–28.Google Scholar
  172. Williams, G., Howell, A., and Jones, M., 1988, The relationship of body weight to response to endocrine therapy, steroid hormone receptors and survival of patients with advanced cancer of the breast, Br. J. Cancer 58: 631–634.Google Scholar
  173. Wolff, G. L., 1987, Body weight and cancer, Am. J. Clin. Nutr. 45 (Suppl.): 168–180.Google Scholar
  174. Wynder, E. L., and Gori, G. B., 1977, Contribution of the environment to cancer incidence: An epidemiologic exercise, J. Natl. Cancer Inst. 58: 825–832.Google Scholar
  175. Yuan, J-M., Yu, M. C., Ross, R. K., Gao, Y-T., and Henderson, B. E., 1988, Risk factors for breast cancer in Chinese women in Shanghai, Cancer Res. 48: 1949–1953.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Bruce Ruggeri
    • 1
  1. 1.Department of PathologyThe Fox Chase Cancer CenterPhiladelphiaUSA

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