The Effects of Caloric Restriction on Neoplasia and Age-Related Degenerative Processes

  • Bruce Ruggeri
Part of the Human Nutrition book series (HUNU, volume 7)


The role of diet in the etiology of cancer is a subject of ongoing controversy and continued research (for reviews, see Reddy and Cohen, 1986; Reddy, 1986; Ip et al., 1986; Cohen, 1987). As noted by Brown (1983), a National Academy of Sciences 2-year study concluded that “although it is difficult to prove firmly a cause-and-effect relationship, the total evidence suggests that some type of dietary components tend to increase the risk of cancer and other types of diets or components tend to decrease the risk” (NAS, 1982). Wynder and Gori (1977) attributed approximately 40% of cancer incidence in men and 60% in women to dietary patterns. Similar estimates for the incidence of potentially preventable cancers in relation to dietary practices have been made by other workers (Bailar, 1979; Cimino and Demopoulous, 1980). Most animal studies indicate that dietary factors probably act at the promotional stage of carcinogenesis (Brown, 1983), although more recent studies (Kritchevsky et al., 1984; Welsch, 1987; Albanes, 1987a,b; Hocman, 1988) suggest that dietary factors (i.e., high-fat, high-calorie intake) may influence both initiation and promotion of tumorigenesis.


Breast Cancer Risk Mammary Tumor Caloric Restriction Dietary Restriction Tumor Incidence 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Bruce Ruggeri
    • 1
  1. 1.Department of PathologyThe Fox Chase Cancer CenterPhiladelphiaUSA

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