Dietary Fiber and Cancer

  • David Kritchevsky
  • David M. Klurfeld
Chapter
Part of the Human Nutrition book series (HUNU, volume 7)

Abstract

Fiber has been defined by Paul and Southgate (1978) as “the sum of the polysaccharides and lignin which are not digested by the endogenous secretions of the human gastrointestinal tract. This fraction has a variable composition as it is made up of several different types of polysaccharides (pectic substances, hemicelluloses, and celluloses) and the non-carbohydrate lignin.” The description of fiber has been expanded to include plant gums, mucilages, and algal polysaccharides. It is convenient to classify these substances into insoluble fiber (cellulose, hemicellulose, lignin), which decreases intestinal transit time and increases fecal bulk, and soluble fiber (pectic substances, gums), which delays gastric emptying.

Keywords

Colon Cancer Bile Acid Bile Salt Colon Carcinogenesis Pectic Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Armstrong, B., and Doll, R., 1975, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices, Im . J. Cancer 15: 617–631.CrossRefGoogle Scholar
  2. Barbolt, T. A., and Abraham, R., 1978, The effect of bran in dimethylhydrazine-induced colon carcinogenesis in the rat, Proc. Soc. Exp. Biol. Med. 157: 656–659.CrossRefGoogle Scholar
  3. Barbolt, T. A., and Abraham, R., 1980, Dose—response, sex differences and the effect of bran in dimethylhydrazine-induced intestinal carcinogenesis in rats, Toxicol. Appl. Pharmacol. 55: 417–422.CrossRefGoogle Scholar
  4. Bauer, H. G., Asp, N. G., Oste, R., Dahlqvist, A., and Fredlund, P. E., 1979, Effect of dietary fiber on the induction of colorectal tumors and fecal glucuronidase activity in the rat, Cancer Res. 39: 3752–3756.Google Scholar
  5. Burkitt, D. P., 1971, Epidemiology of cancer of the colon and rectum, Cancer 28: 3–13.CrossRefGoogle Scholar
  6. Byers, T., 1988, Diet and cancer. Any progress in the interim? Cancer 62: 1713–1724.CrossRefGoogle Scholar
  7. Byers, T., and Graham, S., 1984, The epidemiology of diet and cancer, Adv. Cancer Res. 41: 1–69.CrossRefGoogle Scholar
  8. Cleave, T. L., 1956, The neglect of natural principles in current medical practice, J. Roy. Nay. Med. Serv. 42: 55–82.Google Scholar
  9. Committee on Diet, Nutrition and Cancer, 1982, Diet, nutrition and cancer, National Academy Press, Washington, DC.Google Scholar
  10. Cummings, J. H., and Bingham, S. A., 1987, Dietary fibre, fermentation and large bowel cancer, Cancer Surveys 6: 601–621.Google Scholar
  11. Eastwood, M. A., and Hamilton, D., 1968, Studies on the adsorption of bile salts to non-absorbed components of diet, Biochim. Biophys. Acta 152: 165–173.CrossRefGoogle Scholar
  12. Glober, G. A., Nomura, A., Kamiyama, S., Shimoda, A., and Abba, B. C., 1977, Bowel transit time and stool weight in populations with different colon cancer risks, Lancet 2: 110.CrossRefGoogle Scholar
  13. Gregor, O., Toman, R., and Prusova, F., 1969, Gastrointestinal cancer and nutrition, Gut 10: 1031–1034.CrossRefGoogle Scholar
  14. Hagopian, H. K., Riggs, M. G., Swartz, L. A., and Ingram, V. M., 1977, Effect of n-butyrate on DNA synthesis in chick fibroblasts and HeLa cells, Cell 12: 855–860.CrossRefGoogle Scholar
  15. Hakama, M., and Saxen, E. A., 1967, Cereal consumption and gastric cancer, Int. J. Cancer 2: 265–268.CrossRefGoogle Scholar
  16. Heaton, K. W., Emmett, P. M., Henry, C. L., Thornton, J. R., Manhire, A., and Hartog, M., 1983, Not just fibre: the nutritional consequences of refined carbohydrate foods, Hum. Nutr. Clin. Nutr. 37C: 31–35.Google Scholar
  17. Higginson, J., and Oettle, A. G., 1960, Cancer incidence in the Bantu and “Cape Coloured” races of South Africa: Report of a cancer survey in the Transvaal, J. Natl. Cancer Inst. 24: 589–671.Google Scholar
  18. Hill, M. J., Drasar, B. S., Aries, V. C., Crowther, J. S., Hawksworth, G., and Williams, R. E. O., 1971, Bacteria and the aetiology of cancer of the large bowel, Lancet 1: 95–100.CrossRefGoogle Scholar
  19. Hill, M. J., Maclennan, R., and Newcombe, K., 1979, Diet and large bowel cancer in three socioeconomic groups in Hong Kong, Lancet 1: 436.CrossRefGoogle Scholar
  20. Jacobs, L. R., 1983, Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration, Cancer Res. 43: 4057–4061.Google Scholar
  21. Jacobs, L. R., 1986, Modification of experimental colon carcinogenesis by dietary fibers, Adv. Exp. Biol. Med. 206: 105–118.Google Scholar
  22. Jensen, O. M., Maclennan, R., and Wahrendorf, J., 1982, Diet, bowel function, fecal characteristics and large bowel cancer in Denmark and Finland, Nutr. Cancer 4: 5–19.CrossRefGoogle Scholar
  23. Kassira, E., Parent, L., and Vahouny, G. V., 1976, Colon cancer. An epidemiological survey, Am. J. Dig. Dis. 21: 205–214.CrossRefGoogle Scholar
  24. Kelsay, J. L., Behall, K. M., and Prather, E. S., 1978, Effect of fiber from fruits and vegetables on metabolic responses of human subjects. 1. Bowel transit time, number of defecations, fecal weight, urinary excretions of energy and nitrogen and apparent digestibilities of energy, nitrogen and fat, Am. J. Clin. Nutr. 31: 1149–1153.Google Scholar
  25. Kim, Y. S., Tsao, D., Morita, A., and Bella, A., 1982, Effect of sodium butyrate on three human colorectal adenocarcinoma cell lines in culture, in: Colon Carcinogenesis ( R. A. Malt, and R. C. N. Williamson, eds.), MTP Press, Lancaster, UK, pp. 317–323.Google Scholar
  26. Klurfeld, D. M., and Kritchevsky, D., 1986, Dietary fiber and human cancer: Critique of the literature, Adv. Exp. Med. Biol. 206: 119–135.Google Scholar
  27. Klurfeld, D. M., Weber, M. M., and Kritchevsky, D., 1987, Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat, Cancer Res. 47:2759–2762. Kritchevsky, D., 1983, Fiber, steroids and cancer, Cancer Res. 43 (Suppl.): 24915–2495S.Google Scholar
  28. Kritchevsky, D., 1985, Dietary fiber and cancer, Nutr. Cancer 6: 213–219.CrossRefGoogle Scholar
  29. Kritchevsky, D., and Klurfeld, D. M., 1981, Fat and cancer, in: Nutrition and Cancer: Etiology and Treatment ( G. R. Newell and N. M. Ellison, eds.), Raven Press, New York, pp. 173–188.Google Scholar
  30. Kritchevsky, D., and Klurfeld, D. M., 1986, Influence of caloric intake on experimental carcinogenesis: A review, Adv. Exp. Med. Biol. 206: 55–68.Google Scholar
  31. Kune, S., Kune, G. A., and Watson, L. F., 1987, Case control study of dietary etiological factors: The Melbourne colorectal cancer study, Nutr. Cancer 9: 21–42.CrossRefGoogle Scholar
  32. Lyon, J. L., Mahoney, A. W., West, D. W., Gardner, J. W., Snuth, K. R., Sorenson, A. W., and Stanish, W., 1987, Energy intake: its relationship to colon cancer risk, J. Natl. Cancer Inst. 78: 853–861.Google Scholar
  33. MacDonald, I. A., Webb, G. R., and Mahony, D. E., 1978, Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects and bowel cancer patients, Am. J. Clin. Nutr. 31: S233–S238.Google Scholar
  34. Manousos, O., Day, N. E., Trichopoulous, D., Gerovassilis, F., Tzonou, A., and Polychronopoulou, A., 1983, Diet and colorectal cancer: A case–control study in Greece, Int. J. Cancer 32: 1–5.CrossRefGoogle Scholar
  35. Marquart-Moulin, G., Riboli, E., Cornee, J., Chamay, B., Berthezene, P., and Day, N., 1986, Case-control study on colorectal cancer and diet in Marseilles, Int. J. Cancer 38: 183–191.CrossRefGoogle Scholar
  36. Nigro, N. D., Bhadrachari, N., and Chonichai, C., 1973, A rat model for studying colonic cancer: effect of cholestyramine on induced tumors, Dis. Colon Rectum 16: 438–443.CrossRefGoogle Scholar
  37. Paul, A. A., and Southgate, D. A. T., 1978, McCance and Widdowson’s The Composition of Foods, 4th ed., Elsevier/North-Holland, Biomedical Press, Amsterdam.Google Scholar
  38. Pickle, L. W., Greene, M. H., Ziegler, R. G., Toledo, A., Hoover, R., Lynch, H. T., and Fraumeni, J. F., Jr., 1984, Colorectal cancer in rural Nebraska, Cancer Res. 44: 363–369.Google Scholar
  39. Potter, J. D., and McMichael, A. J., 1986, Diet and cancer of the colon and rectum: A case–control study, J. Natl. Cancer Inst. 76: 557–569.Google Scholar
  40. Reddy, B. S., Hedges, A. R., Laakso, K., and Wynder, E. L., 1978, Metabolic epidemiology of large bowel cancer, Cancer 42: 2832–2838.CrossRefGoogle Scholar
  41. Reddy, B. S., Maeura, Y., and Wayman, M., 1983, Effect of dietary corn bran and autohydrolyzed lignin on 3,2-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in male F344 rats, J. Natl. Cancer Inst. 71: 419–423.Google Scholar
  42. Rogers, A. E., and Longnecker, M. P., 1988, Biology of disease. Dietary and nutritional influences on cancer: A review of epidemiological and experimental data, Lab. Invest. 59: 729–759.Google Scholar
  43. Slattery, M. L., Sorenson, A. W., Mahoney, A. W., French, T. K., Kritchevsky, D., and Street, J. C., 1988, Diet and colon cancer: assessment of risk by fiber type and food source, J. Natl. Cancer Inst. 80: 1474–1480.CrossRefGoogle Scholar
  44. Southgate, D. A. T., and Dumin, J. V. G. A., 1970, Caloric conversion factors. An experimental reassessment of the factors used in the calculation of the energy value of human diets, Br. J. Nutr. 24: 517–535.CrossRefGoogle Scholar
  45. Stocks, P., and Kam, M. K., 1933, A cooperative study of the habits, homelife, dietary and family histories of cancer patients and an equal number of control patients, Ann. Eugen (London) 5: 237–280.CrossRefGoogle Scholar
  46. Story, J. A., and Kritchevsky, D., 1976, Comparison of the binding of various bile acids and bile salts by several types of fiber, J. Nutr. 106: 1292–1294.Google Scholar
  47. Tuyns, A. J., 1986, A case-control study on colorectal cancer in Belgium: Preliminary results, Med. Sociale Preventive 31: 81–82.CrossRefGoogle Scholar
  48. Walker, A. R. P., Walker, B. F., and Walker, A. J., 1986, Faecal pH, dietary fibre intake and proneness to colon cancer in four South African populations, Br . J. Cancer 53: 489–495.CrossRefGoogle Scholar
  49. Watanabe, K., Reddy, B. S., Wong, C. Q., and Weisburger, J. H., 1978, Effect of dietary undegraded carageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea, Cancer Res. 38: 4427–4430.Google Scholar
  50. Willett, W. C., and MacMahon, B., 1984, Diet and cancer—An overview, N. Engl. J. Med. 310: 633–638, 697–703.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • David Kritchevsky
    • 1
  • David M. Klurfeld
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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