Abstract
Polymorphonuclear neutrophilic granulocytes (PMNs) accumulate in large numbers in the gastric mucosa at sites of Helicobacter pylori (H. pylori) infection. The PMNs are found in close vicinity to the bacterial cells, as has been shown by histological examinations of biopsy specimens.1,5 Despite this close proximity, H. pylori is not eradicated and the infection becomes chronic. Obviously H. pylori has developed effective escape mechanisms against the enormous destructive potential of the activated PMNs and establishes a chronic infection. The lasting immune response could be one of the major reasons for the inflammation that can lead to damage of the epithelial cells, resulting in ulcers and carcinomas.
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© 1996 Springer Science+Business Media New York
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Marxer, M. et al. (1996). Interactions of a Catalase- and an Urease-Negative Mutant of Helicobacter Pylori with Polymorphonuclear Granulocytes. In: Newell, D.G., Ketley, J.M., Feldman, R.A. (eds) Campylobacters, Helicobacters, and Related Organisms. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9558-5_133
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DOI: https://doi.org/10.1007/978-1-4757-9558-5_133
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