Effect on Pepsinogen Release of Various Sub-Fractions of H. Pylori Lipopolysaccharide

  • G. O. Young
  • A. J. Lastovica
  • S. Brown
  • J. J. McGovern
  • A. P. Moran

Abstract

The association between H.pylori and duodenal ulcer (DU) disease is well recognized. The role played by H.pylori is, however, less clear. We have previously reported that H.pylori lipopolysaccharide (LPS) stimulates the release of pepsinogen which, as active pepsin, is a known aggressive factor in DU disease7. LPS is a complex molecule, consisting of carbohydrate and lipid moieties, and may also have protein associated with it4. The aim of the study was to examine the effect of sub-fractions of LPS on pepsinogen release by guinea pig gastric mucosa, in order to determine whether any particular moiety is the “active fraction”.

Keywords

Ussing Chamber Aggressive Factor Luminal Perfusate Transmucosal Potential Difference Aqueous Hydrofluoric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Basson M.D. and Modlin I.M. (1988) J. Surg. Res., 44, 82–97.PubMedCrossRefGoogle Scholar
  2. 2.
    Doe W.F., Yang ST., Morrison D.C., Betz S.J. and Henson P.M. (1978) J Exp. Med, 148, 557–568.PubMedCrossRefGoogle Scholar
  3. 3.
    Moran A.P., Helander I.M. and Kosunen T.U. (1992) J. Bacteriol., 174, 1370–1377.PubMedGoogle Scholar
  4. 4.
    Morrison D.C. (1983) Rev Infect diseases, 5, S733–747.CrossRefGoogle Scholar
  5. 5.
    Valkonen K.H., Wadstrom, T. and Moran A.P. (1994) Infect. Immun. 62, 3640–3648.PubMedGoogle Scholar
  6. 6.
    Westphal O. and Jann K. (1965) Methods in Carbohydr. Chem., 5, 83–91.Google Scholar
  7. 7.
    Young C.O., Stemmet, Lastovica A.J., van der Merwe E.L., Louw J.A., Modlin I.M. and Marks I.N. (1992) Aliment. Pharmacol. Ther, 6, 169–177.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. O. Young
    • 1
  • A. J. Lastovica
    • 2
  • S. Brown
    • 1
  • J. J. McGovern
    • 3
  • A. P. Moran
    • 3
  1. 1.Gastrointestinal Clinic, Department of MedicineUniversity of Cape Town and Groote Schuur HospitalCape TownSouth Africa
  2. 2.Department of Medical MicrobiologyRed Cross Children’s HospitalCape TownSouth Africa
  3. 3.Department of MicrobiologyUniversity CollegeGalwayIreland

Personalised recommendations