Effect on Pepsinogen Release of Various Sub-Fractions of H. Pylori Lipopolysaccharide
The association between H.pylori and duodenal ulcer (DU) disease is well recognized. The role played by H.pylori is, however, less clear. We have previously reported that H.pylori lipopolysaccharide (LPS) stimulates the release of pepsinogen which, as active pepsin, is a known aggressive factor in DU disease7. LPS is a complex molecule, consisting of carbohydrate and lipid moieties, and may also have protein associated with it4. The aim of the study was to examine the effect of sub-fractions of LPS on pepsinogen release by guinea pig gastric mucosa, in order to determine whether any particular moiety is the “active fraction”.
KeywordsUssing Chamber Aggressive Factor Luminal Perfusate Transmucosal Potential Difference Aqueous Hydrofluoric Acid
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