The Effect of Lipopolysaccharide from Helicobacter SPP. And Campylobacter SPP. On Pepsinogen Release by Gastric Mucosa

  • A. J. Lastovica
  • G. O. Young
  • S. Brown


Our previous work has shown that lipopolysaccharide (LPS) isolated from H.pylori stimulates the release of pepsinogen by guinea pig gastric mucosa in an Ussing chamber model5. The question arises whether LPS from other Helicobacter species, such as the non-pathogenic H.nemestrinae, or from other bacteria found in the gut, has any effect on pepsinogen release. The aim of the study was to examine the effect on pepsinogen release of lipopolysaccharide isolated from various gut-associated bacteria.


Ussing Chamber Gastric Mucosal Biopsy Transmucosal Potential Difference Mammalian Ringer Pepsinogen Concentration 
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  1. 1.
    Basson MD, Modlin IM. (1988) J Surg Res, 44, 82–97.PubMedCrossRefGoogle Scholar
  2. 2.
    Mills SD, Kujanczyk LA, Penner JL. (1992) J Clin Microbiol, 30, 3175–3180.PubMedGoogle Scholar
  3. 3.
    Preston MA, Penner JL. (1987) Infect Immun, 55, 1806–1812.PubMedGoogle Scholar
  4. 4.
    Westphal O, Jann K. (1965) Methods in Carbohydr Chem, 5, 83–91.Google Scholar
  5. 5.
    Young GO, Stemmet, Lastovica AJ, van der Merwe EL, Louw JA, Modlin IM., Marks IN. (1992) Aliment. Pharmacol.Ther, 6, 169–177.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • A. J. Lastovica
    • 1
  • G. O. Young
    • 2
  • S. Brown
    • 1
  1. 1.Department of Medical MicrobiologyRed Cross HospitalCape TownSouth Africa
  2. 2.Gastrointestinal Clinic, Department of MedicineUniversity of Cape Town and Groote Schuur HospitalCape TownSouth Africa

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