Cross-Reactivities and Strain-Specificity of Monoclonal Antibodies to Campylobacter Jejuni and Helicobacter Pylori Flagellins

  • Chrystala Constantinidou
  • Tobin J. Hellyer
  • Peter T. Richardson
  • Charles W. Penn

Abstract

Campylobacter jejuni are Gram-negative, microaerophilic, spiral rods, motile by means of a single, bi-polar, unsheathed flagellum. They are considered as one of the leading causes of bacterial diarrhoea throughout the world 15. Helicobacter pylori are also spiral, microaerophilic, Gram-negative and motile bacteria by means of a unipolar bundle of 3–6 sheathed flagella. H. pylori is generally acknowledged to be a major cause of gastritis in man. It is also associated with the occurrence of peptic ulceration (for reviews see Blaser 1,2).

Keywords

Vicinal Diol Reactive Clone Motile Bacterium Bacterial Diarrhoea Pylorus NCTC 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Blaser, M. J. (1990) J. Infect. Dis. 161, 626–633.PubMedCrossRefGoogle Scholar
  2. 2.
    Blaser, M. J. (1993) Trends Microbiol. 1, 255–260.PubMedCrossRefGoogle Scholar
  3. 3.
    Eaton, K. A., Morgan, D. R. and Krakowka, S. (1989) Infect. Immun., 59, 1119–1125.Google Scholar
  4. 4.
    Grant, C.C. R., Konkel, M. E., Ciepelk, W. Jr. and Tompkins, L. S. (1993) Inf. Immun., 61, 1764–1771.Google Scholar
  5. 5.
    Guerry, P. S. M., Alm, R. A., Power, M. E., Logan, S. A. and Trust, T. J. (1991) J. Bact., 173, 4757–4764.PubMedGoogle Scholar
  6. 6.
    Guerry, P. S. M., Logan, S. A., and Trust, T. J. (1990) J. Bact., 172, 1853–1860.PubMedGoogle Scholar
  7. 7.
    Kostrzynska, M., Betts, J. D., Austin, J. W. and Trust, T. J. (1991) J. Bact., 173, 937–946.PubMedGoogle Scholar
  8. 8.
    Leying, H., Suerbaum, S., Geis, G. and Haas, R. (1992) Mol. Microb., 6, 2863–2874.CrossRefGoogle Scholar
  9. 9.
    Newell, D. G., McBride, G. and Dolby, J. M. (1985) J. Hyg., 95, 217–227.PubMedCrossRefGoogle Scholar
  10. 10.
    Newell, D. G. (1986) J. Hyg., 96, 377–384.PubMedCrossRefGoogle Scholar
  11. 11.
    Nuijten P. J. M., van der Zeijst, B. A. M. and Newell, D. G. (1991) Inf. Immun., 59 1100–1105.Google Scholar
  12. 12.
    Nuijten, P. J. M., F. J. A. M. van Asten, Gaastra, W. and B. A. M. Van der Zeijst (1990) J. Biol. Chem., 265, 17798–17804.PubMedGoogle Scholar
  13. 13.
    Pavloskis, O. R., Rollins, D. M., Haberberger, R. L., Green, A. E., Habash, L., Strocko, S. and Walker, R. I. (1991) Inf. Immun., 59, 2259–2264.Google Scholar
  14. 14.
    Suerbaum, S., Josenhans, C. and Labigne, A. (1993). J. Bact., 175, 3278–32788.PubMedGoogle Scholar
  15. 15.
    Taylor, D. N (1992) In Campylobacter jejuni: Current Status and Future Trends. Nachamkin, L, Blaser, M. J., and Tompkins, L. S. (Eds). Washington, D. C: American Society for Microbiology, pp 20–30.Google Scholar
  16. 16.
    Wassenaar, T. M., Bleumink-Pluym, N. M. C. and van der Zeijst, B. A. M. (1991) The EMBO J., 10, 2055–2061.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Chrystala Constantinidou
    • 1
  • Tobin J. Hellyer
    • 1
  • Peter T. Richardson
    • 2
  • Charles W. Penn
    • 1
  1. 1.Biology West, School of Biological SciencesUniversity of BirminghamEdgbaston, BirminghamUK
  2. 2.BBSRC Institute of Food ResearchReading LaboratoryUK

Personalised recommendations