Abstract
The Miller-Fisher syndrome (MFS) is an infrequent variation of the more common neuropathy known as the Guillain-Barré syndrome (GBS). The onset of GBS is often preceded by intestinal infections with Campylobacter jejuni. Kuroki et al. 4 reported that 10 of their 14 cases of GBS were preceded by diarrhoea due to C. jejuni of serotype 0:19. In previous investigations LPS from two GBS-related isolates, OH4382 and OH4384 typed as C. jejuni O:19, were compared with that from the 0:19 serostrain1–3 The high Mr components were indistinguishable, with polysaccharide O chains consisting of disaccharide repeating units of an amidated hyaluronic acid. The core oligosaccharide (OS) regions in the O:19 se-rostrain consisted of molecules with terminal units that mimic human gangliosides GDla and GM1. The core OS regions of the OH4382 and OH4384 differed in structure, but contained a terminal trisaccharide epitope, Neu5Acα2→8Neu5Acα2→3Galβ, in mimicry of the human ganglioside GD3. We report here an examination of the LPS of a C. jejuni strain PG836 isolated from a patient with MFS at the Rhode Island Hospital, Providence, R.I., U.S.A. Serotyping and immunoblotting evidence revealed that the isolate was not of serotype O:19, but belonged to a different serotype (O:10).
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References
Aspinall, G.O., Fujimoto, S., McDonald, A.G., Pang, H., Kurjanczyk, L.A. and Penner, J.L. (1994) Infect. Immun. 62, 2122–2125.
Aspinall, G.O., McDonald, A.G., Pang, H., Kurjanczyk, L.A. and Penner, J.L. (1994) Biochemistry 33, 241–249.
Aspinall, G.O., McDonald, A.G. and Pang, H. (1994) Biochemistry 33, 250–255.
Kuroki, S., Saida, T., Nukina, M., Haruta, T., Yoshioka, M., Kobayashi, Y. and Nakanishi, H. (1993) Ann. Neurol. 33, 243–247.
Yuki, N., Taki, T., Takahashi, M., Saito, K., Yoshino, Tai, T., Handa, S. and Miyatake T. (1994) Ann. Neurol. 36, 791–793.
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© 1996 Springer Science+Business Media New York
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Aspinall, G.O., Pang, H., Penner, J.L., Shin, J.E.N. (1996). Lipopolysaccharides from Campylobacter Jejuni Strains Associated with the Onset of the Guillain-Barré and Miller-Fisher Syndromes. In: Newell, D.G., Ketley, J.M., Feldman, R.A. (eds) Campylobacters, Helicobacters, and Related Organisms. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9558-5_124
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DOI: https://doi.org/10.1007/978-1-4757-9558-5_124
Publisher Name: Springer, Boston, MA
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