Detection of a Cytolethal Distending Toxin in Campylobacters of Human and Animal Origin

  • Frank Schulze
  • Ingrid Hänel
  • Erika Borrmann


Although campylobacters are now recognized as important enteric pathogens in human diarrhoeal disease, specific virulence mechanisms in campylobacteriosis have not yet been clearly defined. Numerous attempts were made to elucidate the mechanism by which these pathogens express virulence. It has been shown that potential virulence factors include adhesion to the intestinal mucosa, invasion of intestinal epithelial cells, translocation across the intestinal epithelium, capability of colonization mediated by flagella and the formation of toxins5.


Vero Cell Intestinal Epithelial Cell Positive Strain Diarrhoeal Disease Neutralization Trial 
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  1. 1.
    Florin I. and Antilion F. (1992) J.Med.Microbiol. 37, 22–29.PubMedCrossRefGoogle Scholar
  2. 2.
    Guerrant R.L., Brunton L.L., Schnaitman T.C., Rebhuhn L.I. and Gilman A.G. (1974) Infect. Immun. 10, 320–327.PubMedGoogle Scholar
  3. 3.
    Guerrant R.L., Wanke C.A., Pennie R.A., Barrett L.J., Lima A.A.M. and O’Brien A.D. (1987) Infect. Immun. 55, 2526–2530.PubMedGoogle Scholar
  4. 4.
    Johnson W.M., Lior H. (1988) Microbial Pathogen. 4, 115–126.CrossRefGoogle Scholar
  5. 5.
    Konkel M.E., Corwin M.D., Joens L.A. and Cieplak W. (1992) J. Med. Microbiol. 37, 30–37.PubMedCrossRefGoogle Scholar
  6. 6.
    Laemmli U.K. (1970) Nature 227, 680–685.PubMedCrossRefGoogle Scholar
  7. 7.
    Ohya T., Tominaga K. and Nakazawa M. (1993) J. Vet. Med. Sci. 55, 507–509.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Frank Schulze
    • 1
  • Ingrid Hänel
    • 1
  • Erika Borrmann
    • 1
  1. 1.Federal Institute for Health Protection of Consumers and Veterinary MedicineJena BranchJenaGermany

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