Capacity of a peb1A Mutant of Campylobacter Jejuni to Colonize Chickens

  • R. J. Meinersmann
  • Z. Pei
  • M. J. Blaser

Abstract

PEB1 was first identified as a major immunogenic component of C.jejuni 2. PEB1 was also shown to promote adherence and entry of C.jejuni into human epithelial cell lines and to be homologous to the binding component of glutamine / histidine transport system proteins3. Immunologic identity to the cell binding factor CBF1 described by Kervella et al. 1 was demonstrated. Extracts of PEB1 or antiserum against the protein will inhibit binding of C. jejuni to HeLa cells. The in vivo role of PEB1 has not yet been investigated. The objective of this study was to determine if PEB1 has a role in the colonization of chickens by C.jejuni.

Keywords

HeLa Cell Wild Type Strain Conclusion Table Binding Component Inoculation Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Kervella M., Pages J. M., Pei Z., Grollier G., Blaser M. J., and Fauchere, J. L. (1993) Infect. Immun. 61:3440.PubMedGoogle Scholar
  2. 2.
    Pei Z. Ellison R. T. and Blaser M. J. (1991) J. Biol. Chem. 266:16363.PubMedGoogle Scholar
  3. 3.
    Pei Z. and Blaser M. J. (1993) J. Biol. Chem. 268:1Google Scholar
  4. 4.
    Stern N.J., Bailey, J. S., Blankenship, L. C., Cox N. A., and McHan F. (1988) Avian Dis. 32:330.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • R. J. Meinersmann
    • 1
  • Z. Pei
    • 2
  • M. J. Blaser
    • 2
  1. 1.Agricultural Research ServiceUSDAAthensUSA
  2. 2.Vanderbilt University and VA Medical CenterNashvilleUSA

Personalised recommendations