Capacity of a peb1A Mutant of Campylobacter Jejuni to Colonize Chickens
PEB1 was first identified as a major immunogenic component of C.jejuni 2. PEB1 was also shown to promote adherence and entry of C.jejuni into human epithelial cell lines and to be homologous to the binding component of glutamine / histidine transport system proteins3. Immunologic identity to the cell binding factor CBF1 described by Kervella et al. 1 was demonstrated. Extracts of PEB1 or antiserum against the protein will inhibit binding of C. jejuni to HeLa cells. The in vivo role of PEB1 has not yet been investigated. The objective of this study was to determine if PEB1 has a role in the colonization of chickens by C.jejuni.
KeywordsHeLa Cell Wild Type Strain Conclusion Table Binding Component Inoculation Dose
- 3.Pei Z. and Blaser M. J. (1993) J. Biol. Chem. 268:1Google Scholar