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Evaluation of FlexSure™ HP

A Rapid Serological Assay for H. pylori Detection as Compared to HM-CAP™ EIA and EGD Biopsy

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Campylobacters, Helicobacters, and Related Organisms

Abstract

Helicobacter pylori has been the source of intensive research over the last twelve years since its discovery by Marshall and Warren. It is now accepted as the etiologic agent in chronic superficial gastritis, duodenal ulcers, and gastric ulcers. There has also been established a risk association between H. pylori infection and the development of gastric adenocarcinoma and lymphoma.5,7,13,14,19 The World Health Organization (WHO) in late 1994 classified H. pylori as a definite Category 1 carcinogen, bringing its significance to the point of a public health issue and suggesting the need for broad environmental controls. In February 1994, the National Institutes of Health, (NIH) convened a Consensus Panel which issued statements regarding H. pylori diagnosis and treatment.13 The consensus statement indicated that H. pylori infection should be diagnosed by any of the sensitive and specific methodologies available. In addition it stated that H. pylori infected ulcer patients should be treated with specific anti-microbial therapies to cure the infection.

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References

  1. Barthel J. S. and Everett E. D. (1990) Rev Infect Dis, 12, Sup 1:S107–S114.

    Article  PubMed  Google Scholar 

  2. Chong S. K. F., Lou Q. and Fitzgerald J. F. (1994) Amer J Gastroenterol, 89(8): poster 204.

    Google Scholar 

  3. Evans D. J., Evans D. G., Graham D. Y. and Klein P. D. (1989) Gastroenterology, 96: 1004–1008.

    PubMed  Google Scholar 

  4. Genta R. M. and Graham D. Y. (1994) Gastrointestinal Endoscopy, 40: 342–345.

    Article  PubMed  CAS  Google Scholar 

  5. Graham D. Y. and Go M. F. (1993) Gastroenterology, 105: 279–282.

    PubMed  CAS  Google Scholar 

  6. Graham D. Y., Klein P. D., Evans, D. J., Evans D. G., Alpert L. C., Opekun, A. R. and Boutton T. W. (1987) The Lancet, 1: 1174–1177.

    Article  CAS  Google Scholar 

  7. Hansson L. E., Engstrand L., Nyren O., Evans D. J., Lindgren A., Bergstron R., Andersson B., Athlin L., Bendtsen E. and Tracz P. (1993) Gastroenterology, 105: 1098–1103.

    PubMed  CAS  Google Scholar 

  8. Loffeld R. J. L. F., Stobberingh E. and Arends J. W. (1993) Digestive Diseases, 11: 173–180.

    Article  PubMed  CAS  Google Scholar 

  9. Loffeld R. J. L. F., Vriese W. T. J. and Stobberingh E. E. (1993) European J Gastroenterol & Hepatol, 5(5): 333–337.

    Article  Google Scholar 

  10. Logan R. P. H., Poison R. J., Misiewicz J. J., Rao G., Karim N. Q., Newell D., Johnson P., Wadsworth J., Walker M. M. and Baron J. H. (1991) Gut, 22(12): 1461–1464.

    Article  Google Scholar 

  11. Marshall B. J. (1994) The American Journal of Gastroenterology, 89(8): S116–S128.

    PubMed  CAS  Google Scholar 

  12. Marshall B. J., Plankey M. W., Hoffman S. R., Boyd C. L., Dye K. R., Grierson H. F., Guerrant R. L. and McCallu, R. W. (1991) Am J Gastroenterol, 86(4)438–445.

    PubMed  CAS  Google Scholar 

  13. National Institutes of Health (1994) JAMA, 272:65–69.

    Article  Google Scholar 

  14. Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N. and Sibley R. K. (1991) New England J Med, 325: 1127–1131.

    Article  CAS  Google Scholar 

  15. Quine M. A., Bell G. D., McCloy R. F., Charlton J. E., Devlin H. B. and Hopkins A. (1995) Gut, 36: 462–467.

    Article  PubMed  CAS  Google Scholar 

  16. Sonnenberg A. and Townsend W. F. (1995) Arch Intern Med, 155: 922–928.

    Article  PubMed  CAS  Google Scholar 

  17. Taha A. S., Reid J., Boothmann P., Gemmell C. G., Lee F. D., Sturrock R. D., and Russell R. I. (1993) Gut, 34(4):46–465.

    Article  Google Scholar 

  18. Talley N. J., Newell D. G., Ormand J. E., Carpenter H. A., Wilson W. R., Zinsmeister A. R., Perez-Perez G. L, and Blaser M. J. (1991) J Clin Microbiol, 29(8): 1635–1639.

    PubMed  CAS  Google Scholar 

  19. Tompkins L. S. and Falkow S. (1995) Science, 267: 1621–1622.

    Article  PubMed  CAS  Google Scholar 

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© 1996 Springer Science+Business Media New York

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Shaw, R., Garcia, M., Cheng, E., Marchildon, P., Peacock, J. (1996). Evaluation of FlexSure™ HP. In: Newell, D.G., Ketley, J.M., Feldman, R.A. (eds) Campylobacters, Helicobacters, and Related Organisms. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9558-5_11

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  • DOI: https://doi.org/10.1007/978-1-4757-9558-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9560-8

  • Online ISBN: 978-1-4757-9558-5

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