Summary of Workshop

Pathogenic Mechanisms (Campylobacter)

Abstract

Although the rate at which we are developing a detailed understanding of the molecular pathogenesis of the campylobacters is certainly increasing, we are still only just emerging from the ‘lag’ phase and we still have some way to go before we reach’ stationary’ phase. There is a valuable base of reported work on both the toxins and invasion of host cells by campylobacter, but much of it is controversial, non-molecular or observational in nature. In contrast, the excellent work on the flagellum has done much to characterise the genetic basis of this determinant and established its importance in pathogenesis. The objective of this workshop was to present work that addressed all stages of the process of infection by campylobacters. Our aim was to achieve a structured overview of the abstracts as an update and also to facilitate the generation of ideas and hypotheses for the many as yet unclear aspects of the infection process.

Keywords

Bile Salt Flagellin Gene Cytolethal Distend Toxin Iron Acquisition System 2Naval Medical Research Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Babakhani, F. K. and Joens, L. A. (1993) Infect. Immun. 61, 2723–2726.PubMedGoogle Scholar
  2. 2.
    Bell, J. A. and Manning, D. D. (1990) Infect. Immun. 58(6), 1848–1852.PubMedGoogle Scholar
  3. 3.
    Caldwell, M. B., Walker, R. I., Stewart, S. D. and Rogers, J. E. (1983) Infect. Immun. 42, 1176–1182.PubMedGoogle Scholar
  4. 4.
    Everest, P. H., Goossens, H., Sibbons, P., Lloyd, D. R., Knutton, S., Leece, R., Ketley, J. M. and Williams, P. H. (1993) J. Med. Microbiol. 38, 316–321.PubMedCrossRefGoogle Scholar
  5. 5.
    Field, L. H., Headley, V. L., Payne, S. M. and Berry, L. J. (1986) Infect. Immun. 54, 126–132.PubMedGoogle Scholar
  6. 6.
    Fleischmann, R. D., et al., (1995) Science. 269, 496–512.PubMedCrossRefGoogle Scholar
  7. 7.
    Glenncalvo, E., Bar, W. and Frosch, M. (1994) FEMS Microbiology Letters 123, 299–304.CrossRefGoogle Scholar
  8. 8.
    Konkel, M. E., Hayes, S. F., Joens, L. A. and Cieplak, W., Jr. (1992) Microbial Pathog. 13, 357–370.CrossRefGoogle Scholar
  9. 9.
    McSweegan, E. and Walker, R. I. (1986) Infect. Immun. 53, 141–148.PubMedGoogle Scholar
  10. 10.
    Mills, S. D., Aspinall, G. O., McDonald, A. G., Raju, T. S., Kurjanczyk, L. A. and Penner, J. L. (1992) in Campylobacter jejuni: Current status and future trends (Nachamkin, I., Blaser, M. J. and Tompkins, L. S., eds.). pp. 223–229, American Society for Microbiology, Washington DC.Google Scholar
  11. 11.
    Oelschlaeger, T. A., Guerry, P. and Kopecko, D. J. (1993) Proc. Natl. Acad. Sci. (USA) 90, 6884–6888.CrossRefGoogle Scholar
  12. 12.
    Panigrahi, P., Losonsky, G., DeTolla, L. J. and Morris, J. G., Jr. (1992) Infect. Immun. 60, 4938–4944.PubMedGoogle Scholar
  13. 13.
    Park, S. F. and Richardson, P. T. (1995) J. Bacteriol. 177, 2259–2264.PubMedGoogle Scholar
  14. 14.
    Pei, Z. and Blaser, M. J. (1993) J. Biol. Chem. 268, 18717–18725.PubMedGoogle Scholar
  15. 15.
    Power, M. E., Alm, R. A. and Trust, T. J. (1992) J. Bacteriol. 174, 3874–3883.PubMedGoogle Scholar
  16. 16.
    Purdy, D. and Park, S. F. (1994) J. Gen. Microbiol. 140, 1203–1208.Google Scholar
  17. 17.
    Russell, R. G. and Blake, D. C. (1994) Infect. Immun. 62, 3773–3779.PubMedGoogle Scholar
  18. 18.
    Russell, R. G., O’Donnoghue, M., Blake, D. C, Jr., Zulty, J. and DeTolla, L. J. (1993) J. Infect. Dis. 168, 210–215.PubMedCrossRefGoogle Scholar
  19. 19.
    Wassenaar, T., Fry, B. N. and van der Zeijst, B. A. M. (1995) Microbiology 141, 95–100.PubMedCrossRefGoogle Scholar
  20. 20.
    Wooldridge, K. G. and Williams, P. H. (1993) FEMS. Microbiol. Rev. 12, 325–348.PubMedCrossRefGoogle Scholar
  21. 21.
    Wooldridge, K. G., Williams, P. H. and Ketley, J. M. (1994) J. Bacteriol. 176, 5852–5856.PubMedGoogle Scholar
  22. 22.
    Wren, B. W., Henderson, J. and Ketley, J. M. (1993) Acta Gastro-Enterologica Belgica, Suppl. 56, 18.Google Scholar
  23. 23.
    Wren, B. W., Henderson, J. and Ketley, J. M. (1994) BioTechniques. 16, 7–8.Google Scholar
  24. 24.
    Yao, R. J., Burr, D. H., Doig, P., Trust, T. J., Niu, H. Y. and Guerry, P. (1994) Mol. Microbiol. 14, 883–893.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Julian Ketley
    • 1
  • Patricia Guerry
    • 2
  • Pinaki Panigrahi
    • 3
  1. 1.Department of GeneticsUniversity of LeicesterLeicesterUK
  2. 2.Naval Medical Research InstituteRockvilleUSA
  3. 3.School of MedicineUniversity of MarylandBaltimoreUSA

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